Sequences in Snake Toxin family

ID   CX10_NAJHA     STANDARD;      PRT;    60 AA.
AC   P01453;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 10 (TOXIN CM-4A).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117444
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC   -!- LD(50) IS 4.14 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01718; H3NJ0E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6682 MW;  19277 CN;
     LECNQLIPIA HKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKNSALVK YVCCNTDRCN        60
//

ID   CX11_NAJHA     STANDARD;      PRT;    62 AA.
AC   P01472;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 11 (TOXIN CM-13A) (TOXIN CM-12).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA), AND NAJA HAJE HAJE
OS   (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   CM-13A, SEQUENCE.
RC   SPECIES=N.H.ANNULIFERA; TISSUE=VENOM;
RM   76210208
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 64:219-232(1976).
RN   [2]
RP   CM-12, SEQUENCE, AND REVISIONS TO 53-62 OF CM-13A.
RC   SPECIES=N.H.HAJE; TISSUE=VENOM;
RM   79045337
RA   JOUBERT F.J., TALJAARD N.;
RL   EUR. J. BIOCHEM. 90:359-367(1978).
CC   -!- LD(50) IS 25.2 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01732; H3NJZE.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6842 MW;  20410 CN;
     LKCHNTQLPF IYKTCPEGKN LCFKTTLKKL PLKIPIKRGC AATCPKSSAL LKVVCCSTDK        60
     CN                                                                       62
//

ID   CX1_HEMHA      STANDARD;      PRT;    61 AA.
AC   P01471;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (HEMOLYTIC PROTEIN 12B).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   73140212
RA   FRYKLUND L., EAKER D.;
RL   BIOCHEMISTRY 12:661-667(1973).
CC   -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC       AND HYPOTENSIVE ACTIVITIES.
DR   PIR; A01731; H3RI1L.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6844 MW;  19920 CN;
     LKCHNKLVPF LSKTCPEGKN LCYKMTMLKM PKIPIKRGCT DACPKSSLLV KVVCCNKDKC        60
     N                                                                        61
//

ID   CX1_NAJAT      STANDARD;      PRT;    60 AA.
AC   P01449; P01450;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (CARDIOTOXIN F8) (CYTOTOXIN CM-6) (CARDIOTOXIN-ANALOGUE
DE   I).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS), AND
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   SPECIES=N.ATRA; TISSUE=VENOM;
RM   75204890
RA   HAYASHI K., TAKECHI M., SASAKI T., LEE C.Y.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 64:360-366(1975).
RN   [2]
RP   SEQUENCE.
RC   SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM   75205551
RA   FRYKLUND L., EAKER D.;
RL   BIOCHEMISTRY 14:2860-2865(1975).
RN   [3]
RP   SEQUENCE.
RC   SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM   88209578
RA   OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
CC   -!- LD(50) IS 2.8 MG/KG BY INTRAPERITONEAL INJECTION AND 0.75 MG/KG BY
CC       INTRAVENOUS INJECTION.
CC   -!- CAUTION: THE SEQUENCE OF N.ATRA IN POSITION 45-46 WAS SHOWN AS
CC       SER-ASN IN REF.1 AND REVISED TO ASN-SER IN REF.3.
DR   PIR; A01715; H3NJ1F.
DR   PIR; A90389; H3NJ1K.
DR   PIR; JS0057; JS0057.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6701 MW;  18732 CN;
     LKCNKLIPIA SKTCPAGKNL CYKMFMMSDL TIPVKRGCID VCPKNSLLVK YVCCNTDRCN        60
//

ID   CX1_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01455;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (TOXIN V-II-1).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75059100
RA   WEISE K.H.K., CARLSSON F.H.H., JOUBERT F.J., STRYDOM D.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 354:1317-1326(1973).
CC   -!- LD(50) IS 3 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01720; H3NJ1E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6696 MW;  21040 CN;
     LKCHKLVPPV WKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKNSALVK YVCCSTDKCN        60
//

ID   CX1_NAJME      STANDARD;      PRT;    60 AA.
AC   P01448;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (CYTOTOXIN V-II-1).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   CARLSSON F.H.H., JOUBERT F.J.;
RL   BIOCHIM. BIOPHYS. ACTA 336:453-469(1974).
CC   -!- LD(50) IS 1.37 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01714; H3NJ1W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT       1      1       L -> I (IN EQUAL AMOUNT).
SQ   SEQUENCE   60 AA;  6682 MW;  19858 CN;
     LECNKLVPIA HKTCPAGKNL CYQMYMVSKS TIPVKRGCID VCPKSSLLVK YVCCNTDRCN        60
//

ID   CX1_NAJMO      STANDARD;      PRT;    60 AA.
AC   P01467;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (CARDIOTOXIN XIIB) (CYTOTOXIN V-II-1) (CTX IIB).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   LOUW A.I.;
RL   BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
RN   [2]
RP   STRUCTURE BY NMR.
RM   88029481
RA   OTTING G., STEINMETZ W.E., BOUGIS P.E., ROCHAT H., WUETHRICH K.;
RL   EUR. J. BIOCHEM. 168:609-620(1987).
RN   [3]
RP   STRUCTURE BY NMR.
RM   93279339
RA   O'CONNELL J.F., BOUGIS P.E., WUETHRICH K.;
RL   EUR. J. BIOCHEM. 213:891-900(1993).
CC   -!- LD(50) IS 0.83 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01728; H3NJ1M.
DR   PIR; S02517; S02517.
DR   PDB; 2CCX; 31-JAN-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     21
FT   DISULFID     14     38
FT   DISULFID     42     53
FT   DISULFID     54     59
SQ   SEQUENCE   60 AA;  6826 MW;  18916 CN;
     LKCNQLIPPF WKTCPKGKNL CYKMTMRAAP MVPVKRGCID VCPKSSLLIK YMCCNTNKCN        60
//

ID   CX1_NAJNA      STANDARD;      PRT;    60 AA.
AC   P01447;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (CYTOTOXIN XI).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72086694
RA   HAYASHI K., TAKECHI M., SASAKI T.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 45:1357-1362(1971).
DR   PIR; A01713; H3NJ1I.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6791 MW;  18724 CN;
     LKCNKLIPLA YKTCPAGKNL CYKMYMVSNK TVPVKRGCID VCPKNSLVLK YECCNTDRCN        60
//

ID   CX1_NAJNI      STANDARD;      PRT;    60 AA.
AC   P01456;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (TOXIN V-II-1).
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77022157
RA   BOTES D.P., VILJOEN C.C.;
RL   BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC   -!- LD(50) IS 2.9 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; B01722; H3NJ1C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6697 MW;  21085 CN;
     LKCHKLVPPV WKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKDSALVK YVCCSTDKCN        60
//

ID   CX1_NAJOX      STANDARD;      PRT;    60 AA.
AC   P01451;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1.
OS   NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   GRISHIN E.V., SUKHIKH A.P., ADAMOVICH T.B., OVCHINNIKOV Y.A.;
RL   BIOORG. KHIM. 2:1018-1034(1976).
DR   PIR; A01716; H3NJ1R.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6821 MW;  18931 CN;
     LKCNKLVPIA YKTCPEGKNL CYKMFMMSDL TIPVKRGCID VCPKNSLLVK YVCCNTDRCN        60
//

ID   CX1_NAJPA      STANDARD;      PRT;    60 AA.
AC   P01468;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 1 (CARDIOTOXIN GAMMA).
OS   NAJA PALLIDA (RED SPITTING COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE, AND DISULFIDE BONDS.
RC   TISSUE=VENOM;
RM   75205552
RA   FRYKLUND L., EAKER D.;
RL   BIOCHEMISTRY 14:2865-2871(1975).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).
RM   94254084
RA   BILWES A., REES B., MORAS D., MENEZ R., MENEZ A.;
RL   J. MOL. BIOL. 239:122-136(1994).
CC   -!- CAUTION: THE VENOM OF THIS SNAKE WAS ORIGINALLY THOUGHT TO BE THAT
CC       OF N.NIGRICOLLIS.
DR   PIR; A37578; H3NJ1B.
DR   PDB; 1TGX; 30-APR-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     21
FT   DISULFID     14     38
FT   DISULFID     42     53
FT   DISULFID     54     59
SQ   SEQUENCE   60 AA;  6827 MW;  18973 CN;
     LKCNQLIPPF WKTCPKGKNL CYKMTMRAAP MVPVKRGCID VCPKSSLLIK YMCCNTDKCN        60
//

ID   CX1_NAJSP      STANDARD;      PRT;    81 AA.
AC   Q02454;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   CARDIOTOXIN PRECURSOR.
GN   CTX.
OS   NAJA SPUTATRIX (MALAYAN SPITTING COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   93190317
RA   YEO M.S., JEYASEELAN K., CHUNG M.C., GOPALAKRISHNAKONE P.,
RA   TAN C.H., WONG H.A.;
RL   TOXICON 31:53-60(1993).
DR   EMBL; L04640; NNCRDTXN.
DR   EMBL; S55947; S55947.
DR   PIR; A44335; A44335.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     81       CARDIOTOXIN.
FT   DISULFID     24     42       BY SIMILARITY.
FT   DISULFID     35     59       BY SIMILARITY.
FT   DISULFID     63     74       BY SIMILARITY.
FT   DISULFID     75     80       BY SIMILARITY.
SQ   SEQUENCE   81 AA;  9098 MW;  37274 CN;
     MKTLLLTTVV VTIVCLDLEY TLKCNKLVPL FYKTCPAGKN LCYKMFMVAT PKVPVKRGCI        60
     DVCPKSSLLV KYVCCNTDRC N                                                  81
//

ID   CX2_HEMHA      STANDARD;      PRT;    61 AA.
AC   P24776;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (TOXIN 12A).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77162036
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 74:387-396(1977).
CC   -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC       AND HYPOTENSIVE ACTIVITIES.
CC   -!- LD(50) IS 3.8 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6800 MW;  20126 CN;
     LKCHNKVVPF LSKTCPEGKN LCYKMTLKKV PKIPIKRGCT DACPKSSLLV NVMCCKTDKC        60
     N                                                                        61
//

ID   CX2_NAJAT      STANDARD;      PRT;    60 AA.
AC   P01442;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (CARDIOTOXIN ANALOGUE II).
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77134916
RA   KANEDA N., SASAKI T., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 491:53-66(1977).
CC   -!- LD(50) IS 2.1 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01710; H3NJ2F.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6750 MW;  18984 CN;
     LKCNKLVPLF YKTCPAGKNL CYKMFMVSNL TVPVKRGCID VCPKNSALVK YVCCNTDRCN        60
//

ID   CX2_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01462;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (TOXINS V-II-2 AND V-II-2A).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76119553
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:1893-1900(1975).
CC   -!- LD(50) IS 1.98 MG/KG BY INTRAVENOUS INJECTION.
CC   -!- THE SEQUENCE OF THE MAJOR COMPONENT IS SHOWN, IT IS CALLED TOXIN
CC       V-II-2 AND THE MINOR COMPONENT IS CALLED TOXIN V-II-2A.
DR   PIR; A01725; H3NJ2E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT      52     52       M -> V (IN TOXIN V-II2A).
FT   VARIANT      55     55       N -> S (IN TOXIN V-II2A).
SQ   SEQUENCE   60 AA;  6858 MW;  19209 CN;
     LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCID VCPKDSALVK YMCCNTDKCN        60
//

ID   CX2_NAJKA      STANDARD;      PRT;    60 AA.
AC   P01445;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (CYTOTOXIN CM-7A).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   81154155
RA   JOUBERT F.J., TALJAARD N.;
RL   TOXICON 18:455-467(1980).
CC   -!- LD(50) IS 1.2 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01712; H3NJ2K.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6745 MW;  19284 CN;
     LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID VCPKNSLLVK YVCCNTDRCN        60
//

ID   CX2_NAJME      STANDARD;      PRT;    61 AA.
AC   P01474;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (CYTOTOXINS V-II-2 AND V-II-3).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74275121
RA   CARLSSON F.H.H.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 59:269-276(1974).
CC   -!- THESE TWO SEQUENCES HAVE G & L AT POSITIONS 25 & 27, RESPECTIVELY,
CC       INSTEAD OF 2 MET THAT ARE FOUND IN MOST OTHER CYTOTOXINS & CARDIO-
CC       TOXINS. THE LOW TOXICITY OF THESE 2 PROTEINS MAY POSSIBLY BE CORR-
CC       ELATED WITH THESE CHANGES.
CC   -!- LD(50) IS 6.25 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01734; H3NJ2W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
FT   VARIANT      36     36       N -> K (IN V-II-3).
SQ   SEQUENCE   61 AA;  6850 MW;  19921 CN;
     IKCHNTLLPF IYKTCPEGQN LCFKGTLKFP KKTTYNRGCA ATCPKSSLLV KYVCCNTNKC        60
     N                                                                        61
//

ID   CX2_NAJMO      STANDARD;      PRT;    60 AA.
AC   P01469;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (CARDIOTOXIN XIIA) (CYTOTOXIN V-II-2).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   LOUW A.I.;
RL   BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
RN   [2]
RP   STRUCTURE BY NMR.
RM   88029481
RA   OTTING G., STEINMETZ W.E., BOUGIS P.E., ROCHAT H., WUETHRICH K.;
RL   EUR. J. BIOCHEM. 168:609-620(1987).
CC   -!- LD(50) IS 1.11 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01729; H3NJ2M.
DR   PIR; S02518; S02518.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6800 MW;  19168 CN;
     LKCNQLIPPF WKTCPKGKNL CYKMTMRGAS KVPVKRGCID VCPKSSLLIK YMCCNTDKCN        60
//

ID   CX2_NAJNA      STANDARD;      PRT;    60 AA.
AC   P01440;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (CYTOTOXIN II).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72261302
RA   TAKECHI M., HAYASHI K., SASAKI T.;
RL   MOL. PHARMACOL. 8:446-451(1972).
RN   [2]
RP   DISULFIDE BONDS.
RM   73060175
RA   TAKECHI M., HAYASHI K.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 49:584-590(1972).
DR   PIR; A01708; H3NJ2I.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21
FT   DISULFID     14     38
FT   DISULFID     42     53
FT   DISULFID     54     59
SQ   SEQUENCE   60 AA;  6763 MW;  20106 CN;
     LKCNKLVPLF YKTCPAGKNL CYKMYMVATP KVPVKRGCID VCPKSSLVLK YVCCNTDRCN        60
//

ID   CX2_NAJNI      STANDARD;      PRT;    60 AA.
AC   P01463;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2 (TOXIN V-II-2).
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77022157
RA   BOTES D.P., VILJOEN C.C.;
RL   BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC   -!- LD(50) IS 1.5 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01726; H3NJ2C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6871 MW;  19032 CN;
     LKCHQLIPPF WKTCPEGKNL CYKMYMVATP MIPVKRGCID VCPKNSALVK YMCCNTDKCN        60
//

ID   CX2_NAJOX      STANDARD;      PRT;    60 AA.
AC   P01441;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 2.
OS   NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75058179
RA   GRISHIN E.V., SUKHIKH A.P., ADAMOVICH T.B., OVCHINNIKOV Y.A.,
RA   YUKELSON L.Y.;
RL   FEBS LETT. 48:179-183(1974).
DR   PIR; A01709; H3NJ2R.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6636 MW;  20016 CN;
     LKCKKLVPLF SKTCPAGKNL CYKMFMVAAP HVPVKRGCID VCPKSSLLVK YVCCNTDKCN        60
//

ID   CX3_HEMHA      STANDARD;      PRT;    61 AA.
AC   P24777;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (TOXINS 11 AND 11A).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77162036
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 74:387-396(1977).
CC   -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC       AND HYPOTENSIVE ACTIVITIES.
CC   -!- LD(50) IS 2.5 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
FT   VARIANT      10     10       F -> Y (IN TOXIN 11A).
SQ   SEQUENCE   61 AA;  6793 MW;  21576 CN;
     LKCHNKLVPF LSKTCPDGKN LCYKMSMEVT PMIPIKRGCT DTCPKSSLLV KVVCCKTDKC        60
     N                                                                        61
//

ID   CX3_NAJAT      STANDARD;      PRT;    60 AA.
AC   P01444;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (CARDIOTOXIN ANALOGUE III) (CTX III) (CARDIOTOXIN C-10)
DE   (CYTOTOXIN IV).
OS   NAJA ATRA (CHINESE COBRA), AND NAJA NAJA KAOUTHIA (MONOCLED
OS   COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE, AND REVISION.
RC   SPECIES=N.ATRA; TISSUE=VENOM;
RM   76257817
RA   HAYASHI K., TAKECHI M., KANEDA N., SASAKI T.;
RL   FEBS LETT. 66:210-214(1976).
RN   [2]
RP   SEQUENCE.
RC   SPECIES=N.ATRA; TISSUE=VENOM;
RM   71211413
RA   NARITA K., LEE C.Y.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 41:339-343(1970).
RN   [3]
RP   SEQUENCE.
RC   SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM   90035789
RA   CHIOU S.-H., LIN W.-W., CHANG W.-P.;
RL   INT. J. PEPT. PROTEIN RES. 34:148-152(1989).
RN   [4]
RP   SEQUENCE.
RC   SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM   88209578
RA   OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
RN   [5]
RP   STRUCTURE BY NMR.
RM   94141922
RA   BHASKARAN R., HUANG C.C., CHANG D.K., YU C.;
RL   J. MOL. BIOL. 235:1291-1301(1994).
CC   -!- LD(50) IS 1.48 MG/KG BY INTRAPERITONEAL INJECTION.
CC   -!- CAUTION: THIS TOXIN IS KNOWN AS CYTOTOXIN 3 IN N.ATRA AND
CC       CYTOTOXIN IV IN N.N.KAOUTHIA.
DR   PIR; A01711; H3NJ3F.
DR   PIR; JK0222; JK0222.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6747 MW;  19990 CN;
     LKCNKLVPLF YKTCPAGKNL CYKMFMVATP KVPVKRGCID VCPKSSLLVK YVCCNTDRCN        60
//

ID   CX3_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01459;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (TOXINS CM-8 AND CM-8A).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76210208
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 64:219-232(1976).
CC   -!- THE SEQUENCE OF THE MAJOR COMPONENT IS SHOWN, IT IS CALLED TOXIN
CC       CM-8 AND THE MINOR COMPONENT IS CALLED TOXIN CM-8A.
CC   -!- LD(50) IS 2.98 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01723; H3NJ3E.
DR   PIR; B01723; H3NJME.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT       4      4       Y -> H (IN TOXIN CM-8A).
SQ   SEQUENCE   60 AA;  6839 MW;  20280 CN;
     LKCYKLVPPF WKTCPEGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTDKCN        60
//

ID   CX3_NAJKA      STANDARD;      PRT;    60 AA.
AC   P01446;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (CYTOTOXIN CM-7).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   81154155
RA   JOUBERT F.J., TALJAARD N.;
RL   TOXICON 18:455-467(1980).
RN   [2]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88209578
RA   OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
CC   -!- LD(50) IS 1.2 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; B01712; H3NJ3K.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6717 MW;  18505 CN;
     LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID ACPKNSLLVK YVCCNTDRCN        60
//

ID   CX3_NAJME      STANDARD;      PRT;    61 AA.
AC   P01473;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (COMPONENT 3.20).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76022477
RA   SHIPOLINI R.A., KISSONERGHIS M., BANKS B.E.C.;
RL   EUR. J. BIOCHEM. 56:449-454(1975).
CC   -!- LD(50) IS 12 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A01733; H3NJ3W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6833 MW;  19060 CN;
     IKCHNTPLPF IYKTCPEGNN LCFKGTLKFP KKITYKRGCA DACPKTSALV KYVCCNTDKC        60
     N                                                                        61
//

ID   CX3_NAJMO      STANDARD;      PRT;    60 AA.
AC   P01470;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (CYTOTOXIN V-II-3).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   LOUW A.I.;
RL   BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
CC   -!- LD(50) IS 1.82 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01730; H3NJ3M.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6894 MW;  19065 CN;
     LKCNRLIPPF WKTCPEGKNL CYKMTMRLAP KVPVKRGCID VCPKSSLLIK YMCCNTNKCN        60
//

ID   CX3_NAJNA      STANDARD;      PRT;    60 AA.
AC   P24780;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (CYTOTOXIN IIA).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   85121947
RA   KANEDA N., TAKECHI M., SASAKI T., HAYASHI K.;
RL   BIOCHEM. INT. 9:603-610(1984).
CC   -!- LD(50) IS 40 TO 55 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6745 MW;  19275 CN;
     LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID VCPKNSLVLK YVCCNTDRCN        60
//

ID   CX3_NAJNI      STANDARD;      PRT;    60 AA.
AC   P01458;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 3 (TOXIN V-II-3).
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77022157
RA   BOTES D.P., VILJOEN C.C.;
RL   BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC   -!- LD(50) IS 1.6 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01722; H3NJ3C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6791 MW;  19559 CN;
     LKCNQLIPPF WKTCPKGKNL CYNMYMVSTS TVPVKRGCID VCPKNSALVK YVCCNTDRCN        60
//

ID   CX4_NAJAT      STANDARD;      PRT;    60 AA.
AC   P01443;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 4 (CARDIOTOXIN ANALOGUE IV).
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77134916
RA   KANEDA N., SASAKI T., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 491:53-66(1977).
CC   -!- LD(50) IS 2.1 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; B01710; H3NJ4F.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6793 MW;  18975 CN;
     RKCNKLVPLF YKTCPAGKNL CYKMFMVSNL TVPVKRGCID VCPKNSALVK YVCCNTDRCN        60
//

ID   CX4_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01461;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 4 (TOXIN CM-11).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76210208
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 64:219-232(1976).
CC   -!- LD(50) IS 4.0 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01724; H3NJ4E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6802 MW;  20169 CN;
     LKCNKLIPPF WKTCPKGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTNKCN        60
//

ID   CX4_NAJMO      STANDARD;      PRT;    60 AA.
AC   P01452;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 4 (CARDIOTOXIN V-II-4).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74258253
RA   LOUW A.I.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 58:1022-1029(1974).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
RM   90317830
RA   REES B., BILWES A., SAMAMA J.-P., MORAS D.;
RL   J. MOL. BIOL. 214:281-297(1990).
CC   -!- LD(50) IS 1.97 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01717; H3NJ4M.
DR   PDB; 1CDT; 15-JUL-91.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     21
FT   DISULFID     14     38
FT   DISULFID     42     53
FT   DISULFID     54     59
FT   STRAND        2      4
FT   TURN          8      9
FT   STRAND       11     13
FT   TURN         16     17
FT   STRAND       20     26
FT   TURN         27     30
FT   STRAND       32     39
FT   STRAND       49     54
FT   TURN         57     58
SQ   SEQUENCE   60 AA;  6715 MW;  19123 CN;
     LKCNKLIPIA YKTCPEGKNL CYKMMLASKK MVPVKRGCIN VCPKNSALVK YVCCSTDRCN        60
//

ID   CX5_NAJAT      STANDARD;      PRT;    60 AA.
AC   P07525;
DT   01-APR-1988 (REL. 07, CREATED)
DT   01-APR-1988 (REL. 07, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 5 (CYTOTOXIN D1) (MEMBRANE TOXIN D1).
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   WU W.Y., DU Y.C.;
RL   ACTA BIOCHIM. BIOPHYS. SIN. 16:310-315(1984).
CC   -!- FUNCTION: THIS TOXIN IS CARDIOTOXIC AND CYTOCIDIAL TO YOSHIDA
CC       SARCOMA CELLS.
DR   PIR; JC0001; H3NJ5F.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; CALCIUM CHANNEL INHIBITOR;
KW   MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6810 MW;  19945 CN;
     LKCNKLVPLF YKTCPAGKNL CYKMFMVSNK MVPVKRGCID VCPKSSLLVK YVCCNTDRCN        60
//

ID   CX5_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01464;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 5 (TOXIN CM-6).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117466
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC   -!- LD(50) IS 1.82 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01727; H3NJ5E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6856 MW;  19075 CN;
     LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MIPVKRGCID VCPKNSALVK YMCCNTNKCN        60
//

ID   CX5_NAJHH      STANDARD;      PRT;    60 AA.
AC   P01457;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 5 (CYTOTOXIN CM-8).
OS   NAJA HAJE HAJE (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   78211247
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 534:331-340(1978).
CC   -!- LD(50) IS 2.6 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01721; H3NJ5Y.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6773 MW;  20331 CN;
     LKCHQLVPPF WKTCPEGKNL CYKMYMVSSS TVPVKRGCID VCPKNSALVK YVCCNTDKCN        60
//

ID   CX5_NAJKA      STANDARD;      PRT;    60 AA.
AC   P24779;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 5 (CYTOTOXIN II).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88209578
RA   OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
DR   PIR; JS0028; JS0028.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6654 MW;  17962 CN;
     LKCNKLIPLA YKTCPAGKNL CYKMFMVAAP KVPVKRGCID ACPKNSLLVK YVCCNTDRCN        60
//

ID   CX5_NAJMO      STANDARD;      PRT;    60 AA.
AC   P25517;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 5 (CTX V).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   84013732
RA   BOUGIS P.E., TESSIER M., VAN RIETSCHOTEN J., ROCHAT H., FAUCON J.F.,
RA   DUFOURCQ J.;
RL   MOL. CELL. BIOCHEM. 55:49-64(1983).
CC   -!- LD(50) IS 2.85 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6817 MW;  19524 CN;
     LKCKKLIPLF SKTCPEGKNL CYKMTMRLAP KVPVKRGCID VCPKSSFLVK YECCDTDKCN        60
//

ID   CX6_NAJAT      STANDARD;      PRT;    60 AA.
AC   P80245;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 6 (CARDIOTOXIN 6).
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   94251167
RA   HUNG C.C., WU S.-H., CHIOU S.-H.;
RL   BIOCHEM. MOL. BIOL. INT. 31:1831-1840(1993).
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6689 MW;  19252 CN;
     LKCNQLIPPF YKTCAAGKNL CYKMFMVAAP KVPVKRGCID VCPKSSLLVK YVCCNTDRCN        60
//

ID   CX6_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01465;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 6 (TOXIN CM-2H).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117466
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC   -!- LD(50) IS 5.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; B01727; H3NJ6E.
DR   PIR; C01727; H3NJ6M.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT      52     52       M -> V (IN MINOR COMPONENT).
FT   VARIANT      55     55       N -> S (IN MINOR COMPONENT).
SQ   SEQUENCE   60 AA;  6857 MW;  19152 CN;
     LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCID VCPKDSALVK YMCCNTNKCN        60
//

ID   CX7_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01466;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 7 (TOXIN CM-4B).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117466
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC   -!- LD(50) IS 2.61 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; D01727; H3NJ7E.
DR   PIR; E01727; H3NJ7M.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT      52     52       M -> V (IN MINOR COMPONENT).
FT   VARIANT      55     55       N -> S (IN MINOR COMPONENT).
SQ   SEQUENCE   60 AA;  6856 MW;  19112 CN;
     LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCIN VCPKDSALVK YMCCNTNKCN        60
//

ID   CX8_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01460;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 8 (TOXIN CM-7).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117444
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC   -!- LD(50) IS 2.6 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A91669; H3NJ8E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6812 MW;  20183 CN;
     LKCHKLVPPF WKTCPEGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTNKCN        60
//

ID   CX9_NAJHA      STANDARD;      PRT;    60 AA.
AC   P01454;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN 9 (TOXIN CM-2E).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77117444
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC   -!- LD(50) IS 4.9 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01719; H3NJ9E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     38       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6669 MW;  19422 CN;
     LECNKLVPIA HKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKDSALVK YVCCNTDRCN        60
//

ID   CXH2_ASPSC     STANDARD;      PRT;    63 AA.
AC   P19003;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG S3C2.
OS   ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88185648
RA   JOUBERT F.J.;
RL   INT. J. BIOCHEM. 20:337-345(1988).
CC   -!- LD(50) IS 6.6 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; JS0298; JS0298.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
SQ   SEQUENCE   63 AA;  7173 MW;  22113 CN;
     RKCLNTPLPL FYKTCPEGKD LCYKMNFKLL PKKLSIKRGC TDTCPKSSLL VKVVCCDTDK        60
     CNK                                                                      63
//

ID   CXH4_ASPSC     STANDARD;      PRT;    64 AA.
AC   P19004;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG S4C8.
OS   ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88185648
RA   JOUBERT F.J.;
RL   INT. J. BIOCHEM. 20:337-345(1988).
CC   -!- LD(50) IS 9.4 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; JS0299; JS0299.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     62       BY SIMILARITY.
SQ   SEQUENCE   64 AA;  7316 MW;  17810 CN;
     RKCFNSPGRL VSKPCPEGNN LCYKMSNRMY PPGFNVRRGC AETCPRRNRL LEVVCCCDTD        60
     NCNK                                                                     64
//

ID   CXHA_MATBI     STANDARD;      PRT;    41 AA.
AC   P24742;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG MATICOTOXIN A (FRAGMENT).
OS   MATICORA BIVIRGATA (LONG-GLANDED CORAL SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91263097
RA   TAKASAKI C., YOSHIDA H., SHIMAZU T., TERUUCHI T., TORIBA M.,
RA   TAMIYA N.;
RL   TOXICON 29:191-200(1991).
DR   PIR; C39558; C39558.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   NON_TER      41     41
SQ   SEQUENCE   41 AA;  4677 MW;  7983 CN;
     LICYNTPFKD ISKTCAEGEN LCYYGKKDAV WNLYPIRGCA D                            41
//

ID   CXH_HEMHA      STANDARD;      PRT;    63 AA.
AC   P24778;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG (TOXINS 9B AND 9BB).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77162036
RA   JOUBERT F.J.;
RL   EUR. J. BIOCHEM. 74:387-396(1977).
CC   -!- FUNCTION: THIS TOXIN HAS A VERY LOW TOXICITY.
CC   -!- LD(50) IS 33.5 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
FT   VARIANT      37     37       K -> R (IN TOXIN 9BB).
SQ   SEQUENCE   63 AA;  7193 MW;  20949 CN;
     LICHNRPLPF LHKTCPEGQN ICYKMTLKKT PMKLSVKRGC AATCPSERPL VQVECCKTDK        60
     CNW                                                                      63
//

ID   CXH_NAJKA      STANDARD;      PRT;    62 AA.
AC   P14541;
DT   01-JAN-1990 (REL. 13, CREATED)
DT   01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG (CLBP).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   87247251
RA   INOUE S., OHKURA K., IKEDA K., HAYASHI K.;
RL   FEBS LETT. 218:17-21(1987).
CC   -!- FUNCTION: LOW CYTOTOXIN ACTIVITY.
DR   PIR; A27025; A27025.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6994 MW;  18960 CN;
     LKCHNTQLPF IYKTCPEGKN LCFKATLKKF PLKIPIKRGC ADNCPKNSAL LKYVCCSTDK        60
     CN                                                                       62
//

ID   CXH_NAJNA      STANDARD;      PRT;    62 AA.
AC   P14554;
DT   01-JAN-1990 (REL. 13, CREATED)
DT   01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   CYTOTOXIN HOMOLOG (CLBP) (LESS-CYTOTOXIC BASIC POLYPEPTIDE) (LCBP)
DE   (CARDIOTOXIN V) (CTX V).
OS   NAJA NAJA (INDIAN COBRA), AND NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   SPECIES=N.NAJA, AND N.ATRA; TISSUE=VENOM;
RM   90060345
RA   INOUE S., OKUMURA K., TSUJINO M., OHKURA K., IKEDA K., TAKECHI M.,
RA   TANAKA Y., HAYASHI K.;
RL   FEBS LETT. 257:319-323(1989).
RN   [2]
RP   SEQUENCE.
RC   SPECIES=N.NAJA; TISSUE=VENOM;
RM   90184454
RA   SHAFQAT J., ZAIDI Z.H., JOERNVALL H.;
RL   FEBS LETT. 261:245-246(1990).
RN   [3]
RP   PRELIMINARY SEQUENCE.
RC   SPECIES=N.ATRA; TISSUE=VENOM;
RM   86130665
RA   TAKECHI M., TANAKA Y., HAYASHI K.;
RL   BIOCHEM. INT. 11:795-802(1985).
RN   [4]
RP   PRELIMINARY SEQUENCE.
RC   SPECIES=N.NAJA; TISSUE=VENOM;
RM   87184627
RA   TAKECHI M., TANAKA Y., HAYASHI K.;
RL   BIOCHEM. INT. 14:145-152(1987).
RN   [5]
RP   STRUCTURE BY NMR.
RM   93349889
RA   SINGHAL A.K., CHIEN K.-Y., WU W.-G., RULE G.S.;
RL   BIOCHEMISTRY 32:8036-8044(1993).
CC   -!- FUNCTION: LOW CYTOTOXIN ACTIVITY. DISPLAYS POOR HEMOLYTIC ACTIVITY
CC       BUT IS PROFICIENT AT INDUCING AGGREGATION AND FUSION OF
CC       SPHINGOMYELIN VESICLES.
CC   -!- LD(50) IS 60 MG/KG BY SUBCUTANEOUS INJECTION.
CC   -!- THE TWO SEQUENCES ARE IDENTICAL.
CC   -!- CAUTION: THE SEQUENCE OF POSITIONS 25-32 WAS INCORRECT IN REF.3
CC       AND REF.4 DUE TO THE INVERSION OF THE ORDER OF TWO PEPTIDES.
DR   PIR; S06674; S06674.
DR   PIR; S09703; S09703.
DR   PIR; S08259; S08259.
DR   PDB; 1CVO; 31-JAN-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     40       BY SIMILARITY.
FT   DISULFID     44     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7014 MW;  19456 CN;
     LKCHNTQLPF IYKTCPEGKN LCFKATLKKF PLKFPVKRGC ADNCPKNSAL LKYVCCSTDK        60
     CN                                                                       62
//

ID   MAMB_DENJA     STANDARD;      PRT;    59 AA.
AC   P28375;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   MAMBIN (GLYCOPROTEIN IIB-IIA ANTAGONIST) (PLATELET AGGREGATION
DE   INHIBITOR).
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   92273586
RA   MCDOWELL R.S., DENNIS M.S., LOUIE A., SHUSTER M., MULKERRIN M.G.,
RA   LAZARUS R.A.;
RL   BIOCHEMISTRY 31:4766-4772(1992).
CC   -!- FUNCTION: INHIBITS ADP-INDUCED PLATELET AGGREGATION AND INHIBITS
CC       THE BINDING OF PURIFIED PLATELET FIBRINOGEN RECEPTOR GPIIB-IIIA
CC       TO IMMOBILIZED FIBRINOGEN.
CC   -!- SIMILARITY: STRONG, TO TOXIN S5C1.
DR   PIR; A42561; A42561.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   BLOOD COAGULATION; CELL ADHESION; VENOM.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     37       BY SIMILARITY.
FT   DISULFID     39     51       BY SIMILARITY.
FT   DISULFID     52     57       BY SIMILARITY.
FT   SITE         43     45       CELL ATTACHMENT SITE (POTENTIAL).
SQ   SEQUENCE   59 AA;  6754 MW;  16657 CN;
     RICYNHLGTK PPTTETCQED SCYKNIWTFD NIIRRGCGCF TPRGDMPGPY CCESDKCNL         59
//

ID   NXL1_ACAAN     STANDARD;      PRT;    73 AA.
AC   P01385;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1.
OS   ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   82068043
RA   KIM H.S., TAMIYA N.;
RL   BIOCHEM. J. 193:899-906(1981).
CC   -!- LD(50) IS 0.13 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01656; N2AW1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   73 AA;  8135 MW;  28511 CN;
     VICYRGYNNP QTCPPGENVC FTRTWCDAFC SSRGKVVELG CAATCPIVKS YNEVKCCSTD        60
     KCNPFPVRPR RPP                                                           73
//

ID   NXL1_ASPSC     STANDARD;      PRT;    68 AA.
AC   P25670;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN S4C6).
OS   ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88137796
RA   JOUBERT F.J.;
RL   INT. J. BIOCHEM. 20:93-96(1988).
CC   -!- LD(50) IS 0.13 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   68 AA;  7457 MW;  22578 CN;
     RICYIAPYDH KTCAAGENIC YLKAWCDAWC SSRGKKLEFG CAATCPTVKP GVDISCCDTD        60
     NCNPHPKL                                                                 68
//

ID   NXL1_ASTST     STANDARD;      PRT;    70 AA.
AC   P01380;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN B).
OS   ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79123997
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 175:507-517(1978).
CC   -!- LD(50) IS 0.096 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01651; N2AT1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; AMIDATION; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
FT   MOD_RES      70     70       AMIDATION.
SQ   SEQUENCE   70 AA;  7574 MW;  23780 CN;
     LSCYLGYKHS QTCPPGENVC FVKTWCDGFC NTRGERIIMG CAATCPTAKS GVHIACCSTD        60
     NCNIYAKWGS                                                               70
//

ID   NXL1_BUNMU     STANDARD;      PRT;    74 AA.
AC   P01378;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (ALPHA-BUNGAROTOXIN) (BGTX).
OS   BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72188445
RA   MEBS D., NARITA K., IWANAGA S., SAMEJIMA Y., LEE C.Y.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 353:243-262(1972).
RN   [2]
RP   REVISIONS TO 9-11; 67-68 AND 71-72.
RC   TISSUE=VENOM;
RM   88005156
RA   OHTA M., OHTA K., NISHITANI H., HAYASHI K.;
RL   FEBS LETT. 222:79-82(1987).
RN   [3]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88339978
RA   CHUANG L.Y., CHANG C.-C.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 155:870-876(1988).
RN   [4]
RP   REVISIONS TO 9-11; 67-68 AND MINOR VARIANT.
RC   TISSUE=VENOM;
RM   88294016
RA   KOSEN P.A., FINER-MOORE J., MCCARTHY M.P., BASUS V.J.;
RL   BIOCHEMISTRY 27:2775-2781(1988).
RN   [5]
RP   ANTIGENIC REGIONS.
RM   89378216
RA   KASE R., KITAGAWA H., HAYASHI K., TANOUE K., INAGAKI F.;
RL   FEBS LETT. 254:106-110(1989).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM   89184384
RA   LOVE R.A., STROUD R.M.;
RL   PROTEIN ENG. 1:37-46(1986).
RN   [7]
RP   STRUCTURE BY NMR.
RM   88294014
RA   BASUS V.J., BILLETER M., LOVE R.A., STROUD R.M., KUNTZ I.D.;
RL   BIOCHEMISTRY 27:2763-2771(1988).
RN   [8]
RP   STRUCTURE BY NMR.
RM   88294015
RA   BASUS V.J., SCHEEK R.M.;
RL   BIOCHEMISTRY 27:2772-2775(1988).
RN   [9]
RP   STRUCTURE BY NMR.
RM   94059936
RA   BASUS V.J., SONG G., HAWROT E.;
RL   BIOCHEMISTRY 32:12290-12298(1993).
CC   -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC   -!- SUBUNIT: MONOMER IN SOLUTION, HOMODIMER IN CRYSTAL STATE.
CC   -!- LD(50) IS 0.3 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01649; N2KF1U.
DR   PIR; S02420; S02420.
DR   PIR; A31519; A31519.
DR   PDB; 2ABX; 16-OCT-87.
DR   PDB; 1ABT; 31-JAN-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     23
FT   DISULFID     16     44
FT   DISULFID     29     33
FT   DISULFID     48     59
FT   DISULFID     60     65
FT   VARIANT      31     31       A -> V (IN MINOR VARIANT).
FT   STRAND       25     26
FT   STRAND       41     42
SQ   SEQUENCE   74 AA;  7994 MW;  28837 CN;
     IVCHTTATSP ISAVTCPPGE NLCYRKMWCD AFCSSRGKVV ELGCAATCPS KKPYEEVTCC        60
     STDKCNPHPK QRPG                                                          74
//

ID   NXL1_DENJA     STANDARD;      PRT;    72 AA.
AC   P01393;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN V-III-N1).
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74094133
RA   STRYDOM A.J.C.;
RL   BIOCHIM. BIOPHYS. ACTA 328:491-509(1973).
CC   -!- LD(50) IS 0.38 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01664; N2EP1J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  8185 MW;  28115 CN;
     RTCYKTYSDK SKTCPRGEDI CYTKTWCDGF CSQRGKRVEL GCAATCPKVK TGVEIKCCST        60
     DYCNPFPVWN PR                                                            72
//

ID   NXL1_DENPO     STANDARD;      PRT;    72 AA.
AC   P01396;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN GAMMA) (TOXIN VN1).
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RM   72206049
RA   STRYDOM D.J.;
RL   J. BIOL. CHEM. 247:4029-4042(1972).
CC   -!- LD(50) IS 0.12 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01667; N2EP1D.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  8043 MW;  25023 CN;
     RTCNKTFSDQ SKICPPGENI CYTKTWCDAW CSQRGKRVEL GCAATCPKVK AGVEIKCCST        60
     DDCDKFQFGK PR                                                            72
//

ID   NXL1_DENVI     STANDARD;      PRT;    72 AA.
AC   P01394;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXINS 4.7.3 AND 4.9.3).
OS   DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74309059
RA   BANKS B.E.C., MILEDI R., SHIPOLINI R.A.;
RL   EUR. J. BIOCHEM. 45:457-468(1974).
CC   -!- NEUROTOXIN 4.7.3 DIFFERS FROM 4.9.3 ONLY IN THAT TRP-26 HAS
CC       UNDERGONE PARTIAL PHOTOOXIDATION.
CC   -!- LD(50) IS 0.9 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A01665; N2EP1V.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  7970 MW;  25452 CN;
     RTCYKTPSVK PETCPHGENI CYTETWCDAW CSQRGKREEL GCAATCPKVK AGVGIKCCST        60
     DNCDPFPVKN PR                                                            72
//

ID   NXL1_LATSE     STANDARD;      PRT;    66 AA.
AC   P01379;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (COMPONENT LSIII).
OS   LATICAUDA SEMIFASCIATA (BROAD-BANDED BLUE SEA SNAKE) (ERABU SEA
OS   SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75127384
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 141:389-400(1974).
CC   -!- LD(50) IS 1.24 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01650; N2LT1E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   66 AA;  7260 MW;  22740 CN;
     RECYLNPHDT QTCPSGQEIC YVKSWCNAWC SSRGKVLEFG CAATCPSVNT GTEIKCCSAD        60
     KCNTYP                                                                   66
//

ID   NXL1_NAJHC     STANDARD;      PRT;    72 AA.
AC   P01389;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN III).
OS   NAJA HAJE ANCHIETAE (ANGOLAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76043631
RA   KOPEYAN C., MIRANDA F., ROCHAT H.;
RL   EUR. J. BIOCHEM. 58:117-122(1975).
CC   -!- LD(50) IS 0.067 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01660; N2NJ1A.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  7911 MW;  25602 CN;
     IRCFITPDVT SQACPDGQNI CYTKTWCDNF CGMRGKRVDL GCAATCPTVK PGVDIKCCST        60
     DNCNPFPTRE RS                                                            72
//

ID   NXL1_NAJHH     STANDARD;      PRT;    71 AA.
AC   P25674;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN CM-5).
OS   NAJA HAJE HAJE (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79062487
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
CC   -!- LD(50) IS 0.11 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     14     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7821 MW;  25513 CN;
     IRCFITPDVT SQACPDGHVC YTKMWCDNFC GMRGKRVDLG CAATCPTVKP GVDIKCCSTD        60
     NCNPFPTRKR S                                                             71
//

ID   NXL1_NAJKA     STANDARD;      PRT;    71 AA.
AC   P01391;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN 3) (ALPHA-COBRATOXIN).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   ARNBERG H., EAKER D., KARLSSON E.;
RL   UNPUBLISHED RESULTS, CITED BY:
RL   KARLSSON E.;
RL   EXPERIENTIA 29:1319-1327(1973).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RM   80234630
RA   WALKINSHAW M.D., SAENGER W., MAELICKE A.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 77:2400-2404(1980).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RM   92042051
RA   BETZEL C., LANGE G., PAL G.P., WILSON K.S., MAELICKE A., SAENGER W.;
RL   J. BIOL. CHEM. 266:21530-21536(1991).
RN   [4]
RP   STRUCTURE BY NMR.
RM   91122921
RA   LAPLANTE S.R., MIKOU A., ROBIN M., GUITTET E., DELSUC M.-A.,
RA   CHARPENTIER I., LALLEMAND J.-Y.;
RL   INT. J. PEPT. PROTEIN RES. 36:227-230(1990).
RN   [5]
RP   STRUCTURE BY NMR.
RM   92273600
RA   LE GOAS R., LAPLANTE S.R., MIKOU A., DELSUC M.-A., GUITTET E.,
RA   ROBIN M., CHARPENTIER I., LALLEMAND J.-Y.;
RL   BIOCHEMISTRY 31:4867-4875(1992).
CC   -!- LD(50) IS 0.1 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01662; N2NJ1S.
DR   PDB; 1CTX; 30-SEP-83.
DR   PDB; 2CTX; 31-JAN-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     20
FT   DISULFID     14     41
FT   DISULFID     26     30
FT   DISULFID     45     56
FT   DISULFID     57     62
FT   TURN         16     17
FT   STRAND       20     25
FT   TURN         28     29
FT   HELIX        30     33
FT   STRAND       36     40
FT   STRAND       53     57
FT   TURN         60     61
FT   TURN         68     69
SQ   SEQUENCE   71 AA;  7831 MW;  25409 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDAFC SIRGKRVDLG CAATCPTVKT GVDIQCCSTD        60
     NCNPFPTRKR P                                                             71
//

ID   NXL1_NAJME     STANDARD;      PRT;    71 AA.
AC   P01383;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN 3.9.4).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74169397
RA   SHIPOLINI R.A., BAILEY G.S., BANKS B.E.C.;
RL   EUR. J. BIOCHEM. 42:203-211(1974).
CC   -!- LD(50) IS 1.5 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A01654; N2NJ1W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  8056 MW;  27682 CN;
     KRCYRTPDLK SQTCPPGEDL CYTKKWCADW CTSRGKVIEL GCVATCPKVK PYEQITCCST        60
     DNCNPHPKMK P                                                             71
//

ID   NXL1_NAJNA     STANDARD;      PRT;    71 AA.
AC   P25668; P01392;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (TOXIN A).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72055125
RA   NAKAI K., SASAKI T., HAYASHI K.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 44:893-897(1971).
CC   -!- LD(50) IS 0.15 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01663; N2NJ1I.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20
FT   DISULFID     14     41
FT   DISULFID     26     30
FT   DISULFID     45     56
FT   DISULFID     57     62
SQ   SEQUENCE   71 AA;  7847 MW;  25239 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SIRGKRVDLG CAATCPTVRT GVDIQCCSTD        60
     DCDPFPTRKR P                                                             71
//

ID   NXL1_NAJNI     STANDARD;      PRT;    71 AA.
AC   P01390;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72068724
RA   BOTES D.P.;
RL   J. BIOL. CHEM. 246:7383-7391(1971).
CC   -!- LD(50) IS 0.076 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01661; N2NJ1C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20
FT   DISULFID     14     41
FT   DISULFID     26     30
FT   DISULFID     45     56
FT   DISULFID     57     62
SQ   SEQUENCE   71 AA;  7902 MW;  24340 CN;
     IRCFITPDVT SQACPDGHVC YTKMWCDNFC GMRGKRVDLG CAATCPKVKP GVNIKCCSRD        60
     NCNPFPTRKR S                                                             71
//

ID   NXL1_NAJOX     STANDARD;      PRT;    73 AA.
AC   P01382;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN I).
OS   NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75006884
RA   GRISHIN E.V., SUKHIKH A.P., SLOBODYAN L.N., OVCHINNIKOV Y.A.,
RA   SOROKIN V.M.;
RL   FEBS LETT. 45:118-121(1974).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RM   90353587
RA   MIKHAILOV A.M., NICKITENCKO A.V., TRAKHANOV S.D., VAINSHTEIN B.K.,
RA   CHETVERINA E.V.;
RL   FEBS LETT. 269:255-257(1990).
CC   -!- LD(50) IS 0.56 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A01653; N2NJ1R.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     43       BY SIMILARITY.
FT   DISULFID     28     32       BY SIMILARITY.
FT   DISULFID     47     58       BY SIMILARITY.
FT   DISULFID     59     64       BY SIMILARITY.
SQ   SEQUENCE   73 AA;  8031 MW;  26741 CN;
     ITCYKTPIPI TSETCAPGQN LCYTKTWCDA WCGSRGKVIE LGCAATCPTV ESYQDIKCCS        60
     TDDCNPHPKQ KRP                                                           73
//

ID   NXL1_NOTSC     STANDARD;      PRT;    73 AA.
AC   P01384;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NOTECHIS III-4).
OS   NOTECHIS SCUTATUS SCUTATUS (MAINLAND TIGER SNAKE) (COMMON TIGER
OS   SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80043177
RA   HALPERT J., FOHLMAN J., EAKER D.;
RL   BIOCHIMIE 61:719-723(1979).
CC   -!- LD(50) IS 0.125 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01655; N2NO1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   73 AA;  8060 MW;  27995 CN;
     LICYMGPKTP RTCPRGQNLC YTKTWCDAFC SSRGKVVELG CAATCPIAKS YEDVTCCSTD        60
     NCNPFPVRPR HPP                                                           73
//

ID   NXL1_OPHHA     STANDARD;      PRT;    73 AA.
AC   P01387;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 1 (NEUROTOXIN A).
OS   OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   73231298
RA   JOUBERT F.J.;
RL   BIOCHIM. BIOPHYS. ACTA 317:85-98(1973).
CC   -!- LD(50) IS 0.3 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01658; N2OH1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   73 AA;  8106 MW;  27546 CN;
     TKCYVTPDVK SETCPAGQDI CYTETWCDAW CTSRGKRVDL GCAATCPIVK PGVEIKCCST        60
     DNCNPFPTWR KRP                                                           73
//

ID   NXL2_ASTST     STANDARD;      PRT;    72 AA.
AC   P01381;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (TOXIN C).
OS   ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79123997
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 175:507-517(1978).
CC   -!- LD(50) IS 0.096 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01652; N2AT2.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; AMIDATION; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     13     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
FT   MOD_RES      72     72       AMIDATION.
SQ   SEQUENCE   72 AA;  7790 MW;  26135 CN;
     LSCYLGYKHS QTCPPGENVC FVKTWCDAFC STRGERIVMG CAATCPTAKS GVHIACCSTD        60
     NCNIYTKWGS GR                                                            72
//

ID   NXL2_BUNFL     STANDARD;      PRT;    66 AA.
AC   P15815;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (KAPPA-FLAVITOXIN).
OS   BUNGARUS FLAVICEPS FLAVICEPS (RED-HEADED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88309785
RA   GRANT G.A., FRAZIER M.W., CHIAPPINELLI V.A.;
RL   BIOCHEMISTRY 27:3794-3798(1988).
CC   -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC       COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC       TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR   PIR; A28644; A28644.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     58       BY SIMILARITY.
FT   DISULFID     59     64       BY SIMILARITY.
SQ   SEQUENCE   66 AA;  7259 MW;  21389 CN;
     RTCLISPSST SQTCPKGQDI CFTKAFCDRW CSSRGPVIEQ GCAATCPEFT SRYKSLLCCT        60
     TDNCNH                                                                   66
//

ID   NXL2_BUNMU     STANDARD;      PRT;    66 AA.
AC   P01398;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (KAPPA-BUNGAROTOXIN) (NEURONAL-BUNGAROTOXIN) (TOXIN
DE   F).
OS   BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   85175111
RA   GRANT G.A., CHIAPPINELLI V.A.;
RL   BIOCHEMISTRY 24:1532-1537(1985).
RN   [2]
RP   STRUCTURE BY NMR.
RM   91242387
RA   OSWALD R.E., SUTCLIFFE M.J., BAMBERGER M., LORING R.H., BRASWELL E.,
RA   DOBSON C.M.;
RL   BIOCHEMISTRY 30:4901-4909(1991).
RN   [3]
RP   STRUCTURE BY NMR.
RM   92198912
RA   SUTCLIFFE M.J., DOBSON C.M., OSWALD R.E.;
RL   BIOCHEMISTRY 31:2962-2970(1992).
CC   -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC       COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC       TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
CC   -!- SUBUNIT: HOMODIMER.
DR   PIR; A01669; N1KF2U.
DR   PDB; 1NBT; 31-OCT-93.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     58       BY SIMILARITY.
FT   DISULFID     59     64       BY SIMILARITY.
SQ   SEQUENCE   66 AA;  7275 MW;  20391 CN;
     RTCLISPSST PQTCPNGQDI CFLKAQCDKF CSIRGPVIEQ GCVATCPQFR SNYRSLLCCT        60
     TDNCNH                                                                   66
//

ID   NXL2_DENPO     STANDARD;      PRT;    72 AA.
AC   P01397;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (NEUROTOXIN DELTA) (TOXIN TN2).
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RA   STRYDOM D.J.;
RL   THESIS (1973), UNIVERSITY OF PRETORIA, SOUTH-AFRICA.
DR   PIR; A01668; N2EP2D.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
FT   CONFLICT      7      7       P -> F (IN PIR DATA BANK).
SQ   SEQUENCE   72 AA;  7948 MW;  25602 CN;
     RTCNKTPSDQ SKICPPGENI CYTKTWCDAW CSQRGKIVEL GCAATCPKVK AGVEIKCCST        60
     DNCNKFKFGK PR                                                            72
//

ID   NXL2_DENVI     STANDARD;      PRT;    73 AA.
AC   P01395;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (TOXINS I AND V).
OS   DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77025828
RA   BECHIS G., GRANIER C., VAN RIETSCHOTEN J., JOVER E., ROCHAT H.,
RA   MIRANDA F.;
RL   EUR. J. BIOCHEM. 68:445-456(1976).
CC   -!- THE VARIANT I SEQUENCE IS SHOWN.
CC   -!- LD(50) IS 0.045 MG/KG BY SUBCUTANEOUS INJECTION FOR VARIANT I, AND
CC       0.08 MG/KG FOR VARIANT V.
DR   PIR; A01666; N2EP2V.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
FT   VARIANT      73     73       MISSING (IN VARIANT V).
SQ   SEQUENCE   73 AA;  8054 MW;  26880 CN;
     RTCYKTPSVK PETCPHGENI CYTETWCDAW CSQRGKRVEL GCAATCPKVK AGVGIKCCST        60
     DNCNPFPVWN PRG                                                           73
//

ID   NXL2_NAJME     STANDARD;      PRT;    71 AA.
AC   P01388;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (NEUROTOXIN B).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RM   72181379
RA   BOTES D.P.;
RL   J. BIOL. CHEM. 247:2866-2871(1972).
DR   PIR; A01659; N2NJ2W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     14     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7772 MW;  24650 CN;
     IRCFITPDVT SQICADGHVC YTKTWCDNFC ASRGKRVDLG CAATCPTVKP GVNIKCCSTD        60
     NCNPFPTRNR P                                                             71
//

ID   NXL2_NAJNA     STANDARD;      PRT;    71 AA.
AC   P25669; P01392;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (TOXIN B).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   OHTA M., SASAKI T., HAYASHI K.;
RL   FEBS LETT. 71:161-166(1976).
DR   PIR; A01663; N2NJ1I.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20
FT   DISULFID     14     41
FT   DISULFID     26     30
FT   DISULFID     45     56
FT   DISULFID     57     62
SQ   SEQUENCE   71 AA;  7821 MW;  25431 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SSRGKRVDLG CAATCPTVRT GVDIQCCSTD        60
     DCDPFPTRKR P                                                             71
//

ID   NXL2_OPHHA     STANDARD;      PRT;    73 AA.
AC   P01386;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 2 (NEUROTOXIN B).
OS   OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   73231298
RA   JOUBERT F.J.;
RL   BIOCHIM. BIOPHYS. ACTA 317:85-98(1973).
CC   -!- LD(50) IS 0.35 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01657; N2OH2.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   73 AA;  8053 MW;  27458 CN;
     TKCYVTPDAT SQTCPDGQDI CYTKTWCDGF CSSRGKRIDL GCAATCPKVK PGVDIKCCST        60
     DNCNPFPTWK RKH                                                           73
//

ID   NXL3_BUNMU     STANDARD;      PRT;    87 AA.
AC   P15816;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN CB1 PRECURSOR (KAPPA NEUROTOXIN).
OS   BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90192091
RA   DANSE J.M., GARNIER J.M.;
RL   NUCLEIC ACIDS RES. 18:1050-1050(1990).
CC   -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC       COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC       TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR   EMBL; X51412; BMKNCB1.
DR   PIR; S08399; S08399.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     87       LONG NEUROTOXIN CB1.
FT   DISULFID     24     42       BY SIMILARITY.
FT   DISULFID     35     63       BY SIMILARITY.
FT   DISULFID     48     52       BY SIMILARITY.
FT   DISULFID     67     79       BY SIMILARITY.
FT   DISULFID     80     85       BY SIMILARITY.
SQ   SEQUENCE   87 AA;  9517 MW;  36118 CN;
     MKTLLLTLVV VTIVCLDLGY TKTCLKTPSS TPQTCPQGQD ICFLKVSCEQ FCPIRGPVIE        60
     QGCAATCPEF RSNDRSLLCC TTDNCNH                                            87
//

ID   NXL3_DENPO     STANDARD;      PRT;    72 AA.
AC   P25667;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 3 (TOXIN VN2).
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RA   STRYDOM D.J., HAYLETT T.;
RL   S. AFR. J. CHEM. 30:40-48(1977).
CC   -!- LD(50) IS 0.4 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  7939 MW;  25452 CN;
     RTCNKTFSDQ SKICPPGENI CYTKTWCDAW CSRRGKIVEL GCAATCPKVK AGVGIKCCST        60
     DNCNLFKFGK PR                                                            72
//

ID   NXL3_NAJNA     STANDARD;      PRT;    71 AA.
AC   P25671;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 3 (TOXIN C).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   OHTA M., SASAKI T., HAYASHI K.;
RL   CHEM. PHARM. BULL. 29:1458-1462(1981).
CC   -!- LD(50) IS 0.10 TO 0.15 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     14     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7833 MW;  25533 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDAFC SIRGKRVDLG CAATCPTVKT GVDIQCCSTD        60
     DCDPFPTRKR P                                                             71
//

ID   NXL3_OPHHA     STANDARD;      PRT;    73 AA.
AC   P07526;
DT   01-APR-1988 (REL. 07, CREATED)
DT   01-APR-1988 (REL. 07, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 3 (NEUROTOXIN CM-9).
OS   OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   LIN N.Q., ZHANG Y.S., MU J.F., WANG W.Y., YANG C.J., XIONG Y.L.;
RL   ACTA BIOCHIM. BIOPHYS. SIN. 16:592-596(1984).
DR   PIR; JC0005; N2OH3.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21
FT   DISULFID     14     42
FT   DISULFID     27     31
FT   DISULFID     46     57
FT   DISULFID     58     63
SQ   SEQUENCE   73 AA;  7957 MW;  30326 CN;
     TKCYVTPDVK SETCPAGQDL CYTETWCVAW CTVRGKRVSL TCAAICPIVP PKVSIKCCST        60
     DACGPFPTWP NVR                                                           73
//

ID   NXL4_BUNMU     STANDARD;      PRT;    87 AA.
AC   P15817;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN CR1 PRECURSOR (KAPPA NEUROTOXIN).
OS   BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90192091
RA   DANSE J.M., GARNIER J.M.;
RL   NUCLEIC ACIDS RES. 18:1050-1050(1990).
CC   -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC       COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC       TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR   EMBL; X51413; BMKNCR1.
DR   PIR; S08398; S08398.
DR   PIR; B60549; B60549.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     87       LONG NEUROTOXIN CR1.
FT   DISULFID     24     42       BY SIMILARITY.
FT   DISULFID     35     63       BY SIMILARITY.
FT   DISULFID     48     52       BY SIMILARITY.
FT   DISULFID     67     79       BY SIMILARITY.
FT   DISULFID     80     85       BY SIMILARITY.
SQ   SEQUENCE   87 AA;  9660 MW;  34712 CN;
     MKTLLLSLVV VTIVCLDLGY TRTCLISPSS TPQTCPNGQD ICFRKAQCDN FCHSRGPVIE        60
     QGCVATCPQF RSNYRSLLCC RTDNCNH                                            87
//

ID   NXL4_NAJNA     STANDARD;      PRT;    71 AA.
AC   P25672;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 4 (TOXIN D).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   82113654
RA   OHTA M., SASAKI T., HAYASHI K.;
RL   BIOCHIM. BIOPHYS. ACTA 671:123-128(1981).
CC   -!- LD(50) IS 0.22 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     14     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7889 MW;  25120 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDGFC RIRGERVDLG CAATCPTVKT GVDIQCCSTD        60
     DCDPFPTRKR P                                                             71
//

ID   NXL4_OPHHA     STANDARD;      PRT;    72 AA.
AC   P80156;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 4 (ALPHA-NEUROTOXIN).
OS   OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   93191697
RA   CHANG C.-C., HUANG T.-Y., KUO K.-W., CHEN S.W., HUANG K.F.,
RA   CHIOU S.-H.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 191:214-223(1993).
DR   PIR; JC1474; JC1474.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     15     43       BY SIMILARITY.
FT   DISULFID     28     32       BY SIMILARITY.
FT   DISULFID     47     58       BY SIMILARITY.
FT   DISULFID     59     64       BY SIMILARITY.
SQ   SEQUENCE   72 AA;  8014 MW;  26927 CN;
     TKCYKTGDRI ISEACPPGQD LCYMKTWCDV FCGTRGRVIE LGCTATCPTV KPHEQITCCS        60
     TDNCNPHPKM KQ                                                            72
//

ID   NXL5_NAJNA     STANDARD;      PRT;    71 AA.
AC   P25673;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN 5 (TOXIN E).
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   88125327
RA   HAYASHI K.;
RL   UNPUBLISHED RESULTS, CITED BY:
RL   ENDO T., TAMIYA N.;
RL   PHARMACOL. THER. 34:403-451(1987).
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     20       BY SIMILARITY.
FT   DISULFID     14     41       BY SIMILARITY.
FT   DISULFID     26     30       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7863 MW;  25298 CN;
     IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SRRGERVDLG CAATCPTVKT GVDIQCCSTD        60
     DCDPFPTRKR P                                                             71
//

ID   NXLB_PSETE     STANDARD;      PRT;    71 AA.
AC   P13495;
DT   01-JAN-1990 (REL. 13, CREATED)
DT   01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN B (PSEUDONAJATOXIN B).
OS   PSEUDONAJA TEXTILIS (EASTERN BROWN SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   87246668
RA   TYLER M.I., SPENCE I., BARNETT D., HOWDEN M.E.H.;
RL   EUR. J. BIOCHEM. 166:139-143(1987).
CC   -!- FUNCTION: LETHAL NEUROTOXIN.
CC   -!- LD(50) IS 0.015 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; S00035; S00035.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     58       BY SIMILARITY.
FT   DISULFID     59     64       BY SIMILARITY.
SQ   SEQUENCE   71 AA;  7761 MW;  25164 CN;
     RTCFITPDVK SKPCPPGQEV CYTETWCDGF CGIRGKRVEL GCAATCPTPK KTGIDIQCCS        60
     TDDCNTFPLR P                                                             71
//

ID   NXLD_ACAAN     STANDARD;      PRT;    74 AA.
AC   P34073;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   ACANTHOPHIN D (POSTSYNAPTIC NEUROTOXIN).
OS   ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   SHEUMACK D.D., SPENCE I., TYLER M.I., HOWDEN M.E.H.;
RL   COMP. BIOCHEM. PHYSIOL. 95B:45-50(1990).
DR   PIR; A60518; A60518.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   74 AA;  8387 MW;  26908 CN;
     VICYRKYTNN VKTCPDGENV CYTKMWCDGF CTSRGKVVEL GCAATCPIRK PGNEVKCCST        60
     NKCNHPPKRK KRRP                                                          74
//

ID   NXLH_BUNMU     STANDARD;      PRT;    87 AA.
AC   P15818;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN HOMOLOG PRECURSOR.
OS   BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90192086
RA   DANSE J.M., GARNIER J.M., KEMPF J.;
RL   NUCLEIC ACIDS RES. 18:1045-1045(1990).
DR   EMBL; X51414; BMNHMR.
DR   PIR; S08401; S08401.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     87       LONG NEUROTOXIN HOMOLOG.
SQ   SEQUENCE   87 AA;  9658 MW;  37335 CN;
     MKTLLLTLVV VTIVCLDLGY TMKCKICHFD TCRAGELKVC ASGEKYCFKE SWREARGTRI        60
     ERGCAATCPK GSVYGLYVLC CTTDDCN                                            87
//

ID   NXLH_PSEAU     STANDARD;      PRT;    68 AA.
AC   P14612;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE   LONG NEUROTOXIN HOMOLOG PA ID.
OS   PSEUDECHIS AUSTRALIS (MULGA SNAKE) (KING BROWN SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   89380113
RA   TAKASAKI C.;
RL   J. BIOCHEM. 106:11-16(1989).
CC   -!- FUNCTION: THIS PROTEIN IS NOT TOXIC.
DR   PIR; JU0034; JU0034.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     42       BY SIMILARITY.
FT   DISULFID     27     31       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   68 AA;  7761 MW;  22835 CN;
     LTCYKGRDRS SETCRSEQEL CCTKTWCDQW CQDRGPRLEM GCTATCPRRM PGLDFTCCTT        60
     DNCNPVPT                                                                 68
//

ID   NXS1_ACAAN     STANDARD;      PRT;    62 AA.
AC   P01434;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN AA C).
OS   ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   82160151
RA   KIM H.S., TAMIYA N.;
RL   BIOCHEM. J. 199:211-218(1981).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.08 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01702; N1AW1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6880 MW;  17921 CN;
     MQCCNQQSSQ PKTTTTCPGG VSSCYKKTWR DHRGTIIERG CGCPRVKPGI RLICCKTDEC        60
     NN                                                                       62
//

ID   NXS1_AIPLA     STANDARD;      PRT;    60 AA.
AC   P32879; P01439;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN A.
OS   AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76160626
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 153:79-87(1976).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01707; N1AY1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6726 MW;  16102 CN;
     LTCCNQQSSQ PKTTTDCADN SCYKKTWQDH RGTRIERGCG CPQVKPGIKL ECCKTNECNN        60
//

ID   NXS1_ASTST     STANDARD;      PRT;    60 AA.
AC   P01438; P10461; P19005;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN A).
OS   ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI), HYDROPHIS
OS   ORNATUS (REEF SEA SNAKE), AND ACALYPTOPHIS PERONII (SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   SPECIES=A.STOKESI; TISSUE=VENOM;
RM   79123997
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 175:507-517(1978).
RN   [2]
RP   COMPOSITIONS OF TRYPTIC PEPTIDES.
RC   SPECIES=H.ORNATUS; TISSUE=VENOM;
RM   83308533
RA   TAMIYA N., MAEDA N., COGGER H.G.;
RL   BIOCHEM. J. 213:31-38(1983).
RN   [3]
RP   MAJOR VARIANT, SEQUENCE.
RC   SPECIES=A.PERONII; TISSUE=VENOM;
RM   88132805
RA   MORI N., TU A.T.;
RL   ARCH. BIOCHEM. BIOPHYS. 260:10-17(1988).
RN   [4]
RP   MINOR VARIANT, SEQUENCE.
RC   SPECIES=A.PERONII; TISSUE=VENOM;
RM   89076487
RA   MORI N., TU A.T.;
RL   BIOL. CHEM. HOPPE-SEYLER 369:521-526(1988).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.170 MG/KG BY INTRAVENOUS INJECTION FOR A.PERONII MINOR
CC       TOXIN, 0.125 MG/KG FOR THE MAJOR TOXIN.
CC   -!- LD(50) IS 0.13 MG/KG BY INTRAMUSCULAR INJECTION FOR A.STOKESI.
DR   PIR; A01706; N1AT1.
DR   PIR; A90321; N1AT1F.
DR   PIR; A27580; A27580.
DR   PIR; S02484; S02484.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
FT   VARIANT      43     43       Q -> E (IN A.PERONII MINOR VARIANT).
SQ   SEQUENCE   60 AA;  6599 MW;  16600 CN;
     MTCCNQQSSQ PKTTTNCAGN SCYKKTWSDH RGTIIERGCG CPQVKSGIKL ECCHTNECNN        60
//

ID   NXS1_BOUAN     STANDARD;      PRT;    61 AA.
AC   P34075;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1.
OS   BOULENGERINA ANNULATA ANNULATA (BANDED WATER COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   92263369
RA   WEINSTEIN S.A., SCHMIDT J.J., SMITH L.A.;
RL   TOXICON 29:1315-1327(1991).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.052 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A39327; A39327.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6837 MW;  18691 CN;
     KICYNQPSSQ HPTTKACPGE KNCYRKQWSD HRGTIIERGC GCPTVKPGVK LHCCTTEKCN        60
     N                                                                        61
//

ID   NXS1_BOUCH     STANDARD;      PRT;    62 AA.
AC   P34076;
DT   01-FEB-1994 (REL. 28, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1.
OS   BOULENGERINA CHRISTYI (CHRISTY'S WATER COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   92263369
RA   WEINSTEIN S.A., SCHMIDT J.J., SMITH L.A.;
RL   TOXICON 29:1315-1327(1991).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.083 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; B39327; B39327.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6894 MW;  18864 CN;
     MECHNQQSSQ PPTTTHCSGG ETNCYEKRWH DHRGTIIERG CGCPTVKPGV KLNCCTTDKC        60
     NN                                                                       62
//

ID   NXS1_BUNFA     STANDARD;      PRT;    64 AA.
AC   P10808;
DT   01-JUL-1989 (REL. 11, CREATED)
DT   01-JUL-1989 (REL. 11, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN V-II-1).
OS   BUNGARUS FASCIATUS (BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   89291813
RA   LIU C.-S., CHEN J.-P., CHANG C.-S., LO T.-B.;
RL   J. BIOCHEM. 105:93-97(1989).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; JX0060; JX0060.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     26       BY SIMILARITY.
FT   DISULFID     20     43       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   64 AA;  7272 MW;  18570 CN;
     RICLNQQQST PEDQPTNGQC YIKTDCQNKT WNTHRGSRTD RGCGCPKVKP GINLRCCKTD        60
     KCNE                                                                     64
//

ID   NXS1_DENJA     STANDARD;      PRT;    60 AA.
AC   P01417;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74094133
RA   STRYDOM A.J.C.;
RL   BIOCHIM. BIOPHYS. ACTA 328:491-509(1973).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.11 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01687; N1EP1J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6729 MW;  16753 CN;
     RICYNHQSTT PATTKSCGEN SCYKKTWSDH RGTIIERGCG CPKVKQGIHL HCCQSDKCNN        60
//

ID   NXS1_DENPO     STANDARD;      PRT;    60 AA.
AC   P01416;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72206049
RA   STRYDOM D.J.;
RL   J. BIOL. CHEM. 247:4029-4042(1972).
RN   [2]
RP   STRUCTURE BY NMR.
RM   89052698
RA   LABHARDT A.L., HUNZIKER-KWIK E.H., WUETHRICH K.;
RL   EUR. J. BIOCHEM. 177:295-305(1988).
RN   [3]
RP   STRUCTURE BY NMR.
RM   93059364
RA   BROWN L.R., WUETHRICH K.;
RL   J. MOL. BIOL. 227:1118-1135(1992).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01686; N1EP1D.
DR   PIR; S01797; S01797.
DR   PDB; 1NTX; 31-JAN-94.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW   3D-STRUCTURE.
FT   DISULFID      3     22
FT   DISULFID     17     39
FT   DISULFID     41     52
FT   DISULFID     53     58
SQ   SEQUENCE   60 AA;  6915 MW;  18007 CN;
     RICYNHQSTT RATTKSCEEN SCYKKYWRDH RGTIIERGCG CPKVKPGVGI HCCQSDKCNY        60
//

ID   NXS1_DENVI     STANDARD;      PRT;    60 AA.
AC   P01418;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN 4.11.3).
OS   DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74309059
RA   BANKS B.E.C., MILEDI R., SHIPOLINI R.A.;
RL   EUR. J. BIOCHEM. 45:457-468(1974).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.08 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A91220; N1EP1V.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6743 MW;  17049 CN;
     RICYNHQSTT PATTKSCGEN SCYKKTWSDH RGTIIERGCG CPKVKRGVHL HCCQSDKCNN        60
//

ID   NXS1_ENHSC     STANDARD;      PRT;    60 AA.
AC   P25492; P01436;
DT   01-JUL-1986 (REL. 01, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN 4).
OS   ENHYDRINA SCHISTOSA (BEAKED SEA SNAKE) (COMMON SEA SNAKE), AND
OS   LAPEMIS HARDWICKII (HARDWICK'S SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   TOXIN 4, SEQUENCE.
RC   SPECIES=E.SCHISTOSA; TISSUE=VENOM;
RM   73127342
RA   FRYKLUND L., EAKER D., KARLSSON E.;
RL   BIOCHEMISTRY 11:4633-4640(1972).
RN   [2]
RP   SEQUENCE.
RC   SPECIES=L.HARDWICKII; TISSUE=VENOM;
RM   77246775
RA   FOX J.W., ELZINGA M., TU A.T.;
RL   FEBS LETT. 80:217-220(1977).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.2 MG/KG BY INTRAVENOUS INJECTION FOR E.SCHISTOSA.
DR   PIR; A01705; N1EY1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6697 MW;  16523 CN;
     MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKPGIKL ECCHTNECNN        60
//

ID   NXS1_HEMHA     STANDARD;      PRT;    61 AA.
AC   P01425;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN II).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   71116407
RA   STRYDOM A.J.C., BOTES D.P.;
RL   J. BIOL. CHEM. 246:1341-1349(1971).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.11 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01694; N1RI1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6838 MW;  16908 CN;
     LECHNQQSSQ PPTTKSCPGD TNCYNKRWRD HRGTIIERGC GCPTVKPGIN LKCCTTDRCN        60
     N                                                                        61
//

ID   NXS1_HYDCY     STANDARD;      PRT;    60 AA.
AC   P25494;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (HYDROPHITOXIN A).
OS   HYDROPHIS CYANOCINCTUS (ASIAN ANNULATED SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75160244
RA   LUI C.-S., BLACKWELL R.Q.;
RL   TOXICON 12:543-546(1974).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6729 MW;  16385 CN;
     MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKKGIKL ECCHTNECNN        60
//

ID   NXS1_HYDLA     STANDARD;      PRT;    60 AA.
AC   P01437;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN A).
OS   HYDROPHIS LAPEMOIDES (PERSIAN GULF SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   83308533
RA   TAMIYA N., MAEDA N., COGGER H.G.;
RL   BIOCHEM. J. 213:31-38(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.09 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A90321; N1EY1H.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6777 MW;  16281 CN;
     MTCCNQQSSQ PKTTTNCAES SCYKKTWRDF RGTRIERGCG CPQVKPGIKL ECCHTNECNN        60
//

ID   NXS1_LATSE     STANDARD;      PRT;    83 AA.
AC   P01435;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 PRECURSOR (ERABUTOXIN A, B, AND C).
OS   LATICAUDA SEMIFASCIATA (BROAD-BANDED BLUE SEA SNAKE) (ERABU SEA
OS   SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   ERABUTOXIN A, SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   85226575
RA   TAMIYA T., LAMOUROUX A., JULIEN J.-F., GRIMA B., MALLET J.,
RA   FROMAGEOT P., MENEZ A.;
RL   BIOCHIMIE 67:185-189(1985).
RN   [2]
RP   ERABUTOXIN B, SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90098883
RA   OBARA K., FUSE N., TSUCHIYA T., NONOMURA Y., MENEZ A., TAMIYA T.;
RL   NUCLEIC ACIDS RES. 17:10490-10490(1989).
RN   [3]
RP   ERABUTOXIN C, SEQUENCE FROM N.A.
RC   TISSUE=LIVER;
RM   91065366
RA   FUSE N., TSUCHIYA T., NONOMURA Y., MENEZ A., TAMIYA T.;
RL   EUR. J. BIOCHEM. 193:629-633(1990).
RN   [4]
RP   ERABUTOXIN A AND B, SEQUENCE.
RM   72052052
RA   SATO S., TAMIYA N.;
RL   BIOCHEM. J. 122:453-461(1971).
RN   [5]
RP   ERABUTOXIN C, PARTIAL SEQUENCE.
RM   73220193
RA   TAMIYA N., ABE H.;
RL   BIOCHEM. J. 130:547-555(1972).
RN   [6]
RP   DISULFIDE BONDS.
RM   72052053
RA   ENDO Y., SATO S., ISHII S., TAMIYA N.;
RL   BIOCHEM. J. 122:463-467(1971).
RN   [7]
RP   A, B, AND C VARIANTS, REVISIONS.
RM   78060308
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 167:289-291(1977).
RN   [8]
RP   ERABUTOXIN B, PRELIMINARY SEQUENCE.
RM   77158096
RA   TSERNOGLOU D., PETSKO G.A., TU A.T.;
RL   BIOCHIM. BIOPHYS. ACTA 491:605-608(1977).
RN   [9]
RP   ERABUTOXIN A, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM   77149032
RA   TSERNOGLOU D., PETSKO G.A.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 74:971-974(1977).
RN   [10]
RP   ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RM   77003690
RA   TSERNOGLOU D., PETSKO G.A.;
RL   FEBS LETT. 68:1-4(1976).
RN   [11]
RP   ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM   79231589
RA   KIMBALL M.R., SATO A., RICHARDSON J.S., ROSEN L.S., LOW B.W.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 88:950-959(1979).
RN   [12]
RP   ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
RM   93039914
RA   SALUDJIAN P., PRANGE T., NAVAZA J., MENEZ R., GUILLOTEAU J.P.,
RA   RIES-KAUTT M., DUCRUIX A.;
RL   ACTA CRYSTALLOGR. B 48:520-531(1992).
RN   [13]
RP   ERABUTOXIN A, X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RM   89255415
RA   CORFIELD P.W.R., LEE T.-J., LOW B.W.;
RL   J. BIOL. CHEM. 264:9239-9242(1989).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.15 MG/KG BY INTRAMUSCULAR INJECTION.
DR   EMBL; X02533; LSERAAR.
DR   EMBL; X16950; LSERABUB.
DR   EMBL; X51410; LSERABUTO.
DR   PIR; A01703; N1LT2E.
DR   PIR; A01704; N1LT1E.
DR   PIR; S06931; S06931.
DR   PIR; S14003; S14003.
DR   PDB; 1NXB; 22-OCT-84.
DR   PDB; 3EBX; 09-OCT-88.
DR   PDB; 5EBX; 15-APR-90.
DR   PDB; 6EBX; 15-JAN-93.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL;
KW   3D-STRUCTURE.
FT   SIGNAL        1     21
FT   CHAIN        22     83       SHORT NEUROTOXIN 1.
FT   DISULFID     24     45
FT   DISULFID     38     62
FT   DISULFID     64     75
FT   DISULFID     76     81
FT   VARIANT      47     47       N -> H (IN VARIANTS B & C).
FT   VARIANT      72     72       K -> N (IN VARIANT C).
FT   VARIANT      80     80       V -> R (IN REF. 8: B VARIANT, MAYBE A
FT                                REAL DIFFERENCE BETWEEN THE PHILIPPINE  &
FT                                JAPANESE POPULATIONS.
FT   STRAND       23     25
FT   TURN         29     30
FT   STRAND       35     37
FT   TURN         40     41
FT   STRAND       45     51
FT   STRAND       56     62
FT   TURN         69     70
FT   STRAND       72     76
FT   TURN         79     80
SQ   SEQUENCE   83 AA;  9137 MW;  36368 CN;
     MKTLLLTLVV VTIVCLDLGY TRICFNHQSS QPQTTKTCSP GESSCYNKQW SDFRGTIIER        60
     GCGCPTVKPG IKLSCCESEV CNN                                                83
//

ID   NXS1_NAJAT     STANDARD;      PRT;    62 AA.
AC   P01430;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (COBROTOXIN).
OS   NAJA ATRA (CHINESE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   69294410
RA   YANG C.C., YANG H.J., HUANG J.S.;
RL   BIOCHIM. BIOPHYS. ACTA 188:65-77(1969).
RN   [2]
RP   DISULFIDE BONDS.
RM   71125117
RA   YANG C.C., YANG H.J., CHIU R.H.C.;
RL   BIOCHIM. BIOPHYS. ACTA 214:355-363(1970).
RN   [3]
RP   STRUCTURE BY NMR.
RM   91065386
RA   YU C., LEE C.-S., CHUANG L.-C., SHEI Y.-R., WANG C.Y.;
RL   EUR. J. BIOCHEM. 193:789-799(1990).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01698; N1NJ1F.
DR   PIR; D40667; D40667.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24
FT   DISULFID     17     41
FT   DISULFID     43     54
FT   DISULFID     55     60
SQ   SEQUENCE   62 AA;  6957 MW;  16811 CN;
     LECHNQQSSQ TPTTTGCSGG ETNCYKKRWR DHRGYRTERG CGCPSVKNGI EINCCTTDRC        60
     NN                                                                       62
//

ID   NXS1_NAJHA     STANDARD;      PRT;    61 AA.
AC   P01429;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA) (TOXIN CM-6) (NEUROTOXIN DELTA).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA), NAJA HAJE HAJE (EGYPTIAN
OS   COBRA), AND NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   ALPHA, SEQUENCE.
RC   SPECIES=N.H.ANNULIFERA; TISSUE=VENOM;
RM   69257191
RA   BOTES D.P., STRYDOM D.J.;
RL   J. BIOL. CHEM. 244:4147-4157(1969).
RN   [2]
RP   SEQUENCE.
RC   SPECIES=N.N.HAJE; TISSUE=VENOM;
RM   79062487
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
RN   [3]
RP   DELTA, SEQUENCE.
RC   SPECIES=N.NIVEA; TISSUE=VENOM;
RM   71185682
RA   BOTES D.P., STRYDOM D.J., ANDERSON C.G., CHRISTENSEN P.A.;
RL   J. BIOL. CHEM. 246:3132-3139(1971).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.105 MG/KG BY SUBCUTANEOUS INJECTION FOR ALPHA, 0.10
CC       MG/KG BY INTRAVENOUS INJECTION FOR CM-6, AND 0.086 MG/KG BY
CC       INTRAVENOUS INJECTION FOR DELTA.
CC   -!- THE SEQUENCE OF THESE THREE TOXINS ARE IDENTICAL.
DR   PIR; A01697; N1NJ1E.
DR   PIR; A92084; N1NJ2C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6844 MW;  17503 CN;
     LECHNQQSSQ PPTTKTCPGE TNCYKKRWRD HRGSITERGC GCPSVKKGIE INCCTTDKCN        60
     N                                                                        61
//

ID   NXS1_NAJKA     STANDARD;      PRT;    62 AA.
AC   P14613;
DT   01-APR-1990 (REL. 14, CREATED)
DT   01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (TOXIN C-6).
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   90035789
RA   CHIOU S.-H., LIN W.-W., CHANG W.-P.;
RL   INT. J. PEPT. PROTEIN RES. 34:148-152(1989).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; JK0221; JK0221.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6983 MW;  16757 CN;
     LECHNQQSIQ TPTTTGCSGG ETNCYKKRWR DHRGYRTERG CGCPSVKNGI EINCCTTDRC        60
     NN                                                                       62
//

ID   NXS1_NAJME     STANDARD;      PRT;    61 AA.
AC   P01424;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN D).
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72181379
RA   BOTES D.P.;
RL   J. BIOL. CHEM. 247:2866-2871(1972).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; A01693; N1NJ1W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6804 MW;  17961 CN;
     MECHNQQSSQ PPTTKTCPGE TNCYKKQWSD HRGTIIERGC GCPSVKKGVK INCCTTDRCN        60
     N                                                                        61
//

ID   NXS1_NAJMO     STANDARD;      PRT;    62 AA.
AC   P01431;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN I).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   78043196
RA   GREGOIRE J., ROCHAT H.;
RL   EUR. J. BIOCHEM. 80:283-293(1977).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.04 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01699; N1NJ1M.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7081 MW;  17232 CN;
     LECHNQQSSE PPTTTRCSGG ETNCYKKRWR DHRGYRTERG CGCPTVKKGI ELNCCTTDRC        60
     NN                                                                       62
//

ID   NXS1_NAJOX     STANDARD;      PRT;    61 AA.
AC   P01427;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA) (NEUROTOXIN II).
OS   NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   74298095
RA   ARNBERG H., EAKER D., FRYKLUND L., KARLSSON E.;
RL   BIOCHIM. BIOPHYS. ACTA 359:222-232(1974).
RN   [2]
RP   PRELIMINARY SEQUENCE.
RM   74015986
RA   GRISHIN E.V., SUKHIKH A.P., LUKYANCHUK N.N., SLOBODYAN L.N.,
RA   LIPKIN V.M., OVCHINNIKOV Y.A., SOROKIN V.M.;
RL   FEBS LETT. 36:77-78(1973).
RN   [3]
RP   STRUCTURE BY NMR.
RM   93279322
RA   GOLOVANOV A.P., LOMIZE A.L., ARSENIEV A.S., UTKIN Y.N., TSETLIN V.I.;
RL   EUR. J. BIOCHEM. 213:1213-1223(1993).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; A01696; N1NJ1R.
DR   PDB; 1NOR; 31-OCT-93.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW   3D-STRUCTURE.
FT   DISULFID      3     23
FT   DISULFID     17     40
FT   DISULFID     42     53
FT   DISULFID     54     59
SQ   SEQUENCE   61 AA;  6885 MW;  17042 CN;
     LECHNQQSSQ PPTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVN LNCCRTDRCN        60
     N                                                                        61
//

ID   NXS1_NAJPA     STANDARD;      PRT;    61 AA.
AC   P01426;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS   NAJA PALLIDA (RED SPITTING COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   EAKER D.L., PORATH J.;
RL   JPN. J. MICROBIOL. 11:353-355(1967).
RN   [2]
RP   STRUCTURE BY NMR.
RM   93075732
RA   ZINN-JUSTIN S., ROUMESTAND C., GILQUIN B., BONTEMS F., MENEZ A.,
RA   TOMA F.;
RL   BIOCHEMISTRY 31:11335-11347(1992).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.036 MG/KG BY SUBCUTANEOUS INJECTION.
CC   -!- CAUTION: THE VENOM OF THIS SNAKE WAS ORIGINALLY THOUGHT TO BE THAT
CC       OF N.NIGRICOLLIS.
DR   PIR; A01695; N1NJ1B.
DR   PDB; 1NEA; 31-OCT-93.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW   3D-STRUCTURE.
FT   DISULFID      3     23
FT   DISULFID     17     40
FT   DISULFID     42     53
FT   DISULFID     54     59
SQ   SEQUENCE   61 AA;  6795 MW;  18257 CN;
     LECHNQQSSQ PPTTKTCPGE TNCYKKVWRD HRGTIIERGC GCPTVKPGIK LNCCTTDKCN        60
     N                                                                        61
//

ID   NXS1_NAJPH     STANDARD;      PRT;    61 AA.
AC   P01428;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1.
OS   NAJA PHILIPPINENSIS (PHILIPPINE COBRA), AND NAJA SAMARENSIS (VISAYAN
OS   COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   MAJOR COMPONENT, SEQUENCE.
RC   SPECIES=N.PHILIPPINENSIS; TISSUE=VENOM;
RM   75040608
RA   HAUERT J., MAIRE M., SUSSMANN A., BARGETZI J.P.;
RL   INT. J. PEPT. PROTEIN RES. 6:201-222(1974).
RN   [2]
RP   MINOR COMPONENT, SEQUENCE.
RC   SPECIES=N.PHILIPPINENSIS, AND N.SAMARENSIS; TISSUE=VENOM;
RA   HAUERT J.;
RL   THESIS (1977), UNIVERSITY OF GENEVA, SWITZERLAND.
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.05 MG/KG BY INTRAVENOUS INJECTION.
CC   -!- THE SEQUENCE OF SHORT NEUROTOXIN 1 FROM N.N.SAMARENSIS IS
CC       IDENTICAL WITH THE MAJOR COMPONENT FROM N.N.PHILIPPINENSIS.
DR   PIR; A91768; N1NJ1P.
DR   PIR; B94448; N1NJ2P.
DR   PIR; A01696; N1NJ1S.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   VARIANT      55     55       R -> T (IN MINOR COMPONENT).
SQ   SEQUENCE   61 AA;  6873 MW;  17338 CN;
     LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK LNCCRTDRCN        60
     N                                                                        61
//

ID   NXS1_PSEAU     STANDARD;      PRT;    62 AA.
AC   P25497;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 1 (NEUROTOXIN PA A).
OS   PSEUDECHIS AUSTRALIS (MULGA SNAKE) (KING BROWN SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   86130341
RA   TAKASAKI C., TAMIYA N.;
RL   BIOCHEM. J. 232:367-371(1985).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.076 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6758 MW;  18858 CN;
     MTCCNQQSSQ PKTTTICAGG ESSCYKKTWS DHRGSRTERG CGCPHVKPGI KLTCCKTDEC        60
     NN                                                                       62
//

ID   NXS2_AIPLA     STANDARD;      PRT;    81 AA.
AC   P19959; P01439;
DT   01-FEB-1991 (REL. 17, CREATED)
DT   01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN B PRECURSOR.
OS   AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90232535
RA   DUCANCEL F., GUIGNERY-FRELAT G., BOULAIN J.-C., MENEZ A.;
RL   TOXICON 28:119-123(1990).
RN   [2]
RP   SEQUENCE OF 22-81.
RC   TISSUE=VENOM;
RM   76160626
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 153:79-87(1976).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR   EMBL; X13373; ALTOXB.
DR   PIR; A01707; N1AY1.
DR   PIR; S03391; S03391.
DR   PIR; A34019; A34019.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     81       SHORT NEUROTOXIN B.
FT   DISULFID     24     43       BY SIMILARITY.
FT   DISULFID     38     60       BY SIMILARITY.
FT   DISULFID     62     73       BY SIMILARITY.
FT   DISULFID     74     79       BY SIMILARITY.
SQ   SEQUENCE   81 AA;  9047 MW;  30666 CN;
     MKTLLLTLVV VTIVCLDLGY TLTCCNQQSS QPKTTTDCAD NSCYKMTWRD HRGTRIERGC        60
     GCPQVKPGIK LECCKTNECN N                                                  81
//

ID   NXS2_BUNFA     STANDARD;      PRT;    63 AA.
AC   P14534;
DT   01-JAN-1990 (REL. 13, CREATED)
DT   01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (TOXIN V-II-2) (FASCIATOXIN).
OS   BUNGARUS FASCIATUS (BANDED KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   89246298
RA   LIU C.-S., HSIAO P.-W., CHANG C.-S., TZENG M.-C., LO T.-B.;
RL   BIOCHEM. J. 259:153-158(1989).
CC   -!- FUNCTION: BLOCKS BOTH THE MUSCLE-TWITCH RESPONSE TO NERVE
CC       STIMULATION AND THE RESPONSE TO EXOGENOUS ACETYLCHOLINE.
CC   -!- IN CONTRAST TO OTHER SNAKE TOXINS THE ACTION OF THIS TOXIN IS
CC       REVERSIBLE.
CC   -!- UNUSUAL A.A. SEQUENCE DISTINCTLY DIFFERENT FROM OTHER SHORT-CHAIN
CC       TYPE TOXINS.
DR   PIR; S03864; S03864.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     15     39       BY SIMILARITY.
FT   DISULFID     43     49       BY SIMILARITY.
FT   DISULFID     50     55       BY SIMILARITY.
SQ   SEQUENCE   63 AA;  6847 MW;  21415 CN;
     LKCHKAQFPN IETQCKWQTL CFQRDVKPHP SSMIVLRGCT SSCGKGAMCC ATDLCNGPST        60
     PST                                                                      63
//

ID   NXS2_ENHSC     STANDARD;      PRT;    60 AA.
AC   P25493; P01436;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (TOXIN 5) (PELAMITOXIN A) (HYDROPHITOXIN B).
OS   ENHYDRINA SCHISTOSA (BEAKED SEA SNAKE) (COMMON SEA SNAKE),
OS   PELAMIS PLATURUS (YELLOW-BELLIED SEA SNAKE) (PELAGIC SEA SNAKE),
OS   AND HYDROPHIS CYANOCINCTUS (ASIAN ANNULATED SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   TOXIN 5, SEQUENCE.
RC   SPECIES=E.SCHISTOSA; TISSUE=VENOM;
RM   73127342
RA   FRYKLUND L., EAKER D., KARLSSON E.;
RL   BIOCHEMISTRY 11:4633-4640(1972).
RN   [2]
RP   PELAMITOXIN A, SEQUENCE.
RC   SPECIES=P.PLATURUS; TISSUE=VENOM;
RM   77105547
RA   WANG C.L., LIU C.-S., HUNG Y.O., BLACKWELL R.Q.;
RL   TOXICON 14:459-466(1976).
RN   [3]
RP   HYDROPHITOXIN B, SEQUENCE.
RC   SPECIES=H.CYNOCINCTUS; TISSUE=VENOM;
RM   75160244
RA   LUI C.-S., BLACKWELL R.Q.;
RL   TOXICON 12:543-546(1974).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.07 MG/KG BY INTRAPERITONAL INJECTION FOR PELAMITOXIN
CC       A AND 0.085 MG/KG BY INTRAVENOUS INJECTION FOR HYDROPHITOXIN B.
DR   PIR; B01705; N1EY15.
DR   PIR; A94310; N1EY1P.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6687 MW;  16569 CN;
     MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKSGIKL ECCHTNECNN        60
//

ID   NXS2_HEMHA     STANDARD;      PRT;    61 AA.
AC   P01433;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (TOXIN IV).
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   71116407
RA   STRYDOM A.J.C., BOTES D.P.;
RL   J. BIOL. CHEM. 246:1341-1349(1971).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.09 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01701; N1RI2.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6832 MW;  18592 CN;
     LECHNQQSSQ TPTTQTCPGE TNCYKKQWSD HRGSRTERGC GCPTVKPGIK LKCCTTDRCN        60
     K                                                                        61
//

ID   NXS2_LATCO     STANDARD;      PRT;    62 AA.
AC   P10457;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN II.
OS   LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   STRAIN=JAPANESE AND PHILLIPINE; TISSUE=VENOM;
RA   TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA   GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL   TOXICON SUPPL. 3:445-447(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; B25866; B25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7037 MW;  17544 CN;
     RRCYNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPTVKPGI KLRCCESEDC        60
     NN                                                                       62
//

ID   NXS2_NAJHA     STANDARD;      PRT;    61 AA.
AC   P01422;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (TOXIN CM-14) (TOXIN V-N-I2).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.12 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01691; N1NJ2E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6915 MW;  18174 CN;
     MICHNQQSSQ PPTIKTCPGE TNCYKKRWRD HRGTIIERGC GCPSVKKGVG IYCCKTNKCN        60
     R                                                                        61
//

ID   NXS2_NAJHH     STANDARD;      PRT;    61 AA.
AC   P25675;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (TOXIN CM-10A).
OS   NAJA HAJE HAJE (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79062487
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
CC   -!- LD(50) IS 0.08 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6888 MW;  18339 CN;
     MICHNQQSSQ PPTIKTCPGE TNCYKKQWRD HRGTIIERGC GCPSVKKGVG IYCCKTDKCN        60
     R                                                                        61
//

ID   NXS2_NAJNI     STANDARD;      PRT;    61 AA.
AC   P01423;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 2 (NEUROTOXIN BETA).
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   72068724
RA   BOTES D.P.;
RL   J. BIOL. CHEM. 246:7383-7391(1971).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.08 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01692; N1NJ1C.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6975 MW;  18088 CN;
     MICHNQQSSQ RPTIKTCPGE TNCYKKRWRD HRGTIIERGC GCPSVKKGVG IYCCKTDKCN        60
     R                                                                        61
//

ID   NXS3_AIPLA     STANDARD;      PRT;    60 AA.
AC   P19958; P01439;
DT   01-FEB-1991 (REL. 17, CREATED)
DT   01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN C.
OS   AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76160626
RA   MAEDA N., TAMIYA N.;
RL   BIOCHEM. J. 153:79-87(1976).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR   PIR; A01707; N1AY1.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6726 MW;  16270 CN;
     LTCCNQQSSQ PKTTTDCADN SCYKKTWKDH RGTRIERGCG CPQVKPGIKL ECCKTNECNN        60
//

ID   NXS3_NAJHA     STANDARD;      PRT;    61 AA.
AC   P01420;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 3 (TOXIN CM-10) (TOXIN V-NH-I1).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 5.0 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01689; N1NJ3E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6885 MW;  17822 CN;
     MICYKQQSLQ FPITTVCPGE KNCYKKQWSG HRGTIIERGC GCPSVKKGIE INCCTTDKCN        60
     R                                                                        61
//

ID   NXS3_NAJMO     STANDARD;      PRT;    62 AA.
AC   P01432;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 3 (NEUROTOXIN III).
OS   NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   78043196
RA   GREGOIRE J., ROCHAT H.;
RL   EUR. J. BIOCHEM. 80:283-293(1977).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 0.05 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01700; N1NJ3M.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7218 MW;  17843 CN;
     LNCHNQMSAQ PPTTTRCSRW ETNCYKKRWR DHRGYKTERG CGCPTVKKGI QLHCCTSDNC        60
     NN                                                                       62
//

ID   NXS4_AIPLA     STANDARD;      PRT;    81 AA.
AC   P19960;
DT   01-FEB-1991 (REL. 17, CREATED)
DT   01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN D PRECURSOR.
OS   AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90232535
RA   DUCANCEL F., GUIGNERY-FRELAT G., BOULAIN J.-C., MENEZ A.;
RL   TOXICON 28:119-123(1990).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   EMBL; X13372; ALTOXD.
DR   PIR; S03390; S03390.
DR   PIR; B34019; B34019.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     81       SHORT NEUROTOXIN D.
FT   DISULFID     24     43       BY SIMILARITY.
FT   DISULFID     38     60       BY SIMILARITY.
FT   DISULFID     62     73       BY SIMILARITY.
FT   DISULFID     74     79       BY SIMILARITY.
SQ   SEQUENCE   81 AA;  9017 MW;  31151 CN;
     MKTLLLTLVV VTIVCLDLGY TLTCCNQQSS QPKTTTDCAD DSCYKKTWKD HRGTRIERGC        60
     GCPQVKPGIK LECCKTNECN N                                                  81
//

ID   NXS4_NAJHA     STANDARD;      PRT;    61 AA.
AC   P01421;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN 4 (TOXIN CM-12) (TOXIN V-NH-I2).
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
CC   -!- LD(50) IS 62.5 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01690; N1NJ4E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6913 MW;  17794 CN;
     MICYKQRSLQ FPITTVCPGE KNCYKKQWSG HRGTIIERGC GCPSVKKGIE INCCTTDKCN        60
     R                                                                        61
//

ID   NXSA_LATCR     STANDARD;      PRT;    62 AA.
AC   P25495;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN A.
OS   LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA   GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL   TOXICON SUPPL. 3:445-447(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7023 MW;  16883 CN;
     RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTIIERG CGCPTVKPGI KLRCCQSDDC        60
     NN                                                                       62
//

ID   NXSB_LATCR     STANDARD;      PRT;    62 AA.
AC   P25496;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN B.
OS   LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA   GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL   TOXICON SUPPL. 3:445-447(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7040 MW;  16436 CN;
     RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTIIERG CGCPQVKSGI KLRCCQSDDC        60
     NN                                                                       62
//

ID   NXSB_LATLA     STANDARD;      PRT;    62 AA.
AC   P10459;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN B.
OS   LATICAUDA LATICAUDATA (BLUE-RINGED SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   86159724
RA   TAMIYA N.,
RL   UNPUBLISHED RESULTS, CITED BY:
RL   ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL   HAYASHI K.;
RL   BIOCHEMISTRY 25:395-404(1986).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; G25866; G25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6973 MW;  17490 CN;
     RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTITERG CGCPQVKSGI KLTCCQSDDC        60
     NN                                                                       62
//

ID   NXSC_LATCO     STANDARD;      PRT;    62 AA.
AC   P10455;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN C.
OS   LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   STRAIN=SALOMON ISLAND AND FIJI; TISSUE=VENOM;
RA   TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA   GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL   TOXICON SUPPL. 3:445-447(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; C25866; C25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7064 MW;  17319 CN;
     RRCYNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPKVKPGI KLRCCESEDC        60
     NN                                                                       62
//

ID   NXSC_LATCR     STANDARD;      PRT;    62 AA.
AC   P10458;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN C.
OS   LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   86159724
RA   TAMIYA N.,
RL   UNPUBLISHED RESULTS, CITED BY:
RL   ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL   HAYASHI K.;
RL   BIOCHEMISTRY 25:395-404(1986).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; F25866; F25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7101 MW;  16950 CN;
     RRCFNQQSSQ PQTNKSCPPG ENSCYRKQWR DHRGTIIERG CGCPTVKPGI KLRCCQSEDC        60
     NN                                                                       62
//

ID   NXSC_LATLA     STANDARD;      PRT;    62 AA.
AC   P10460;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN C.
OS   LATICAUDA LATICAUDATA (BLUE-RINGED SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   86159724
RA   TAMIYA N.,
RL   UNPUBLISHED RESULTS, CITED BY:
RL   ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL   HAYASHI K.;
RL   BIOCHEMISTRY 25:395-404(1986).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; E25866; E25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7087 MW;  17450 CN;
     RRCFNQQSSQ PQTNKSCPPG ENSCYRKQWR DHRGTIIERG CGCPTVKPGV KLRCCQSEDC        60
     NN                                                                       62
//

ID   NXSD_LATCO     STANDARD;      PRT;    62 AA.
AC   P10456;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SHORT NEUROTOXIN D.
OS   LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   STRAIN=NEW CALEDONIA; TISSUE=VENOM;
RA   TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA   GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL   TOXICON SUPPL. 3:445-447(1983).
CC   -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC       TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC       ACETYLCHOLINE RECEPTOR.
DR   PIR; D25866; D25866.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     43     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  7048 MW;  17299 CN;
     RRCFNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPKVKPGI KLRCCESEDC        60
     NN                                                                       62
//

ID   TS24_DENJA     STANDARD;      PRT;    62 AA.
AC   P01407;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-TYPE VENOM PROTEIN S2C4.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79171275
RA   JOUBERT F.J., TALJAARD N.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:571-580(1979).
CC   -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC       IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC   -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO IDENTICAL CHAINS
CC       LINKED BY AT LEAST TWO INTERCHAIN DISULFIDE BONDS.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
DR   PIR; A01678; V6EP2J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   62 AA;  6726 MW;  18029 CN;
     LTCVTDKSFG GVNTEECAAG QKICFKNWKK MGPKLYDVKR GCTATCPKAD DDGCVKCCNT        60
     DK                                                                       62
//

ID   TS81_DENAN     STANDARD;      PRT;    62 AA.
AC   P01410;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-TYPE VENOM PROTEIN C8S2, CHAIN 1.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80070629
RA   JOUBERT F.J., VILJOEN C.C.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC   -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC       IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC   -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC       CHAINS, C8S2 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC       DISULFIDE BONDS.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
DR   PIR; A01680; V6EP8A.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   62 AA;  6684 MW;  18939 CN;
     LTCVTGKSIG GISTEECAAG QKRCFKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCNI        60
     DK                                                                       62
//

ID   TS82_DENAN     STANDARD;      PRT;    62 AA.
AC   P01411;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-TYPE VENOM PROTEIN C8S2, CHAIN 2.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80070629
RA   JOUBERT F.J., VILJOEN C.C.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC   -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC       IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC   -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC       CHAINS, C8S2 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC       DISULFIDE BONDS.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
DR   PIR; A01681; V6EP82.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   62 AA;  6582 MW;  18636 CN;
     LTCVTGKSIG GISTEECAAG QKRCNKKWTK MGPKLYDVSR GCAATCPTAD EYGCVKCCNT        60
     DK                                                                       62
//

ID   TS91_DENAN     STANDARD;      PRT;    63 AA.
AC   P01408;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-TYPE VENOM PROTEIN C9S3, CHAIN 1.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80070629
RA   JOUBERT F.J., VILJOEN C.C.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC   -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC       IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC   -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC       CHAINS, C9S3 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC       DISULFIDE BONDS.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
DR   PIR; A01679; V6EP9A.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   63 AA;  6785 MW;  19643 CN;
     LTCVTGKSIG GISTEECAAG QKICFKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCKT        60
     DRN                                                                      63
//

ID   TS92_DENAN     STANDARD;      PRT;    63 AA.
AC   P01409;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-TYPE VENOM PROTEIN C9S3, CHAIN 2.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80070629
RA   JOUBERT F.J., VILJOEN C.C.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC   -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC       IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC   -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC       CHAINS, C9S3 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC       DISULFIDE BONDS.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
DR   PIR; B01679; V6EP92.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   63 AA;  6738 MW;  18837 CN;
     LTCVTGKSIG GISTEECAAG QKICNKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCNT        60
     DRN                                                                      63
//

ID   TSYL_DENAN     STANDARD;      PRT;    86 AA.
AC   P17696;
DT   01-AUG-1990 (REL. 15, CREATED)
DT   01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-LIKE VENOM PROTEIN PRECURSOR.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   90221903
RA   ROWAN E., DUCANCEL F., DOLJANSKY Y., HARVEY A., MENEZ A.,
RA   BOULAIN J.-C.;
RL   NUCLEIC ACIDS RES. 18:1639-1639(1990).
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
CC   -!- SIMILARITY: TO SYNERGISTIC-TYPE SNAKE VENOM PROTEINS.
DR   EMBL; X51467; DASLTOX.
DR   PIR; S09235; S09235.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     86       SYNERGISTIC-LIKE PROTEIN.
SQ   SEQUENCE   86 AA;  9307 MW;  37744 CN;
     MKTLLLTLVV VTIVCLDLGY TLTCVTGKSI GGISTEECAA GQKICFKKWT KMGPKLYDVS        60
     RGCTATCPKA DEYGCVKCCK TDRCNK                                             86
//

ID   TSYL_DENPO     STANDARD;      PRT;    65 AA.
AC   P25518;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   SYNERGISTIC-LIKE VENOM PROTEIN CM-3.
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   85285976
RA   JOUBERT F.J.;
RL   INT. J. BIOCHEM. 17:695-699(1985).
CC   -!- FUNCTION: NOT KNOWN. DOES NOT SHOW A SYNERGETIC TOXIC EFFECT.
CC   -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC       BONDS.
CC   -!- LD(50) IS 56 MG/KG BY INTRAVENOUS INJECTION.
CC   -!- SIMILARITY: TO SYNERGISTIC-TYPE SNAKE VENOM PROTEINS.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
SQ   SEQUENCE   65 AA;  7344 MW;  20980 CN;
     LTCVTSKSIF GITTEDCPDG QNLCFKRRHY VVPKIYDITR GCVATCPIPE NYDSIHCCKT        60
     EKCNN                                                                    65
//

ID   TX02_DENAN     STANDARD;      PRT;    60 AA.
AC   P25684;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN C10S2C2.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80242820
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 623:449-456(1980).
CC   -!- LD(50) IS 23 +-3 MG/KG BY INTRAVENOUS INJECTION.
CC   -!- SIMILARITY: STRONG, TO CALCISEPTINE.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6818 MW;  17412 CN;
     RICYSHKASL PRATKTCVEN SCYKMFIRTS PDYISDRGCG CPTAMWPYQT ACCKGDRCNK        60
//

ID   TX12_TRIWA     STANDARD;      PRT;    22 AA.
AC   P24335;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT   01-AUG-1992 (REL. 23, LAST ANNOTATION UPDATE)
DE   TOXINS 1 AND 2.
OS   TRIMERESURUS WAGLERI (WAGLER'S PIT VIPER).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91263101
RA   WEINSTEIN S.A., SCHMIDT J.J., BERNHEIMER A.W., SMITH L.A.;
RL   TOXICON 29:227-236(1991).
CC   -!- FUNCTION: ELICIT TACHYPNEA, OCULAR PROCTOSIS, RAPID COLLAPSE
CC       AND SPASMS IN MICE.
CC   -!- THE SEQUENCE SHOWN IS THAT OF TOXIN 1.
DR   PIR; A39559; A39559.
DR   PIR; B39559; B39559.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      9     13       PROBABLE.
FT   VARIANT      10     10       H -> Y (IN TOXIN 2).
SQ   SEQUENCE   22 AA;  2522 MW;  2631 CN;
     GGKPDLRPCH PPCHYIPRPK PR                                                 22
//

ID   TX31_DENAN     STANDARD;      PRT;    80 AA.
AC   P18329;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN C13S1C1 PRECURSOR.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RA   DUCANCEL F.;
RL   SUBMITTED (MAR-1990) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [2]
RP   SEQUENCE OF 22-80.
RC   TISSUE=VENOM;
RM   80242820
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 623:449-456(1980).
CC   -!- LD(50) IS 40 +- 3 MG/KG BY INTRAVENOUS INJECTION.
DR   EMBL; X52260; DAFLP.
DR   EMBL; X53410; DADACSCI.
DR   PIR; S10464; S10464.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   TOXIN; VENOM; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     80       TOXIN C13S1C1.
FT   DISULFID     24     43       BY SIMILARITY.
FT   DISULFID     38     60       BY SIMILARITY.
FT   DISULFID     62     73       BY SIMILARITY.
FT   DISULFID     74     79       BY SIMILARITY.
FT   CONFLICT     56     56       MISSING (IN REF. 2).
SQ   SEQUENCE   80 AA;  8954 MW;  32543 CN;
     MKTLLLTLLV VTIVCLDLAH TRICYSHKLL QAKTTKTCEE NSCYKRSLPK IPLIIIGRGC        60
     GCPLTLPFLR IKCCTSDKCN                                                    80
//

ID   TX48_DENJA     STANDARD;      PRT;    60 AA.
AC   P25683;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN S4C8.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   81044628
RA   JOUBERT F.J., TALJAARD N.;
RL   INT. J. BIOCHEM. 12:567-574(1980).
CC   -!- LD(50) IS 13.7 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6968 MW;  17513 CN;
     RICYTHKSLQ AKTTKSCEGN TCYKMFIRTS REYISERGCG CPTAMWPYQT ECCKGDRCNK        60
//

ID   TX49_DENVI     STANDARD;      PRT;    60 AA.
AC   P01405;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN 4.9.6.
OS   DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   75075137
RA   SHIPOLINI R.A., BANKS B.E.C.;
RL   EUR. J. BIOCHEM. 49:399-405(1974).
CC   -!- LD(50) IS >3.3 MG/KG BY INTRAPERITONEAL INJECTION.
DR   PIR; A01676; T5EP2V.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     38       BY SIMILARITY.
FT   DISULFID     40     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6800 MW;  17236 CN;
     MICYSHKTPQ NSATITCEEK TCYKFVTKLP GVILARGCGC PKKEIFRKSI HCCRSDKCNE        60
//

ID   TX50_DENJA     STANDARD;      PRT;    58 AA.
AC   P01419;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN S5C10.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RM   79232598
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 579:228-233(1979).
CC   -!- LD(50) IS 5.5 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01688; N1EP2J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     50       BY SIMILARITY.
FT   DISULFID     51     56       BY SIMILARITY.
SQ   SEQUENCE   58 AA;  6521 MW;  16040 CN;
     RICYNHQSNT PATTKSCVEN SCYKSIWADH RGTIIKRGCG CPRVKSKIKC CKSDNCNL          58
//

ID   TX51_DENJA     STANDARD;      PRT;    61 AA.
AC   P01413;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   TOXIN S5C1.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79232598
RA   JOUBERT F.J., TALJAARD N.;
RL   BIOCHIM. BIOPHYS. ACTA 579:228-233(1979).
CC   -!- FUNCTION: INHIBITS ADP-INDUCED PLATELET AGGREGATION AND INHIBITS
CC       THE BINDING OF PURIFIED PLATELET FIBRINOGEN RECEPTOR GPIIB-IIIA
CC       TO IMMOBILIZED FIBRINOGEN (BY SIMILARITY TO MAMBIN).
CC   -!- SIMILARITY: STRONG, TO MAMBIN.
DR   PIR; A01683; T6EP5J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   BLOOD COAGULATION; CELL ADHESION; VENOM.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     16     39       BY SIMILARITY.
FT   DISULFID     41     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
FT   SITE         45     47       CELL ATTACHMENT SITE (POTENTIAL).
SQ   SEQUENCE   61 AA;  7024 MW;  17382 CN;
     RICYNHLGTK PPTTECTQED SCYKNIWRNI TFDNIRRGCG CFTPRGDMPG PYCCESDKCN        60
     L                                                                        61
//

ID   TX54_DENJA     STANDARD;      PRT;    60 AA.
AC   P01406;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN S5C4.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   78216714
RA   JOUBERT F.J., STRYDOM A.J.C., TALJAARD N.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 359:741-749(1978).
CC   -!- LD(50) IS >250 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01677; T5EP2J.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6772 MW;  17208 CN;
     MICYSHKTPQ NSATITCEEK TCYKKFVTNV PGVILARGCG CPKKEIFRSI HCCRSDKCNE        60
//

ID   TX64_DENJA     STANDARD;      PRT;    63 AA.
AC   P25682;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN S6C4.
OS   DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J., TALJAARD N.;
RL   S. AFR. J. CHEM. 32:151-155(1979).
CC   -!- LD(50) IS 10 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     43     55       BY SIMILARITY.
FT   DISULFID     56     61       BY SIMILARITY.
SQ   SEQUENCE   63 AA;  7397 MW;  20521 CN;
     LECYRCGVSG CHLRTTCSAK EKFCAKQHNR ISTLWWHGCV ETCTEDETWK FYRKCCTTNL        60
     CNI                                                                      63
//

ID   TXAC_DENPO     STANDARD;      PRT;    61 AA.
AC   P25681;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   ACETYLCHOLINESTERASE TOXIN C.
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J., TALJAARD N.;
RL   S. AFR. J. CHEM. 31:107-110(1978).
CC   -!- FUNCTION: INHIBITS ACETYLCHOLINESTERASE.
CC   -!- LD(50) IS 2.1 +- 0.2 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6817 MW;  19099 CN;
     TICYSHTTTS RAILKDCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDYLEV KCCTSPDKCN        60
     Y                                                                        61
//

ID   TXCA_DENPO     STANDARD;      PRT;    60 AA.
AC   P22947;
DT   01-AUG-1991 (REL. 19, CREATED)
DT   01-AUG-1991 (REL. 19, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   CALCISEPTINE (L-TYPE CALCIUM CHANNEL BLOCKER).
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91172823
RA   DE WEILLE J.R., SCHWEITZ H., MAES P., TARTAR A., LAZDUNSKI M.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 88:2437-2440(1991).
CC   -!- FUNCTION: THIS SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL IS A
CC       SMOOTH MUSCLE RELAXANT AND AN INHIBITOR OF CARDIAC CONTRACTIONS.
CC   -!- THE SENSITIVITY IS HIGHER IN CELLS OF THE CARDIOVASCULAR SYSTEM.
CC       NEURONAL, AND INSULINOMA CELLS L-TYPE CALCIUM CHANNEL ARE MORE
CC       RESISTANTS. A TOTAL RESISTANCE IS FOUND IN SKELETAL MUSCLE CELLS.
CC   -!- SIMILARITY: STRONG, TO THE TOXIN FS-2 AND TO C10S2C2.
DR   PIR; A39165; A39165.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; CYTOTOXIN; CARDIOTOXIN; CALCIUM CHANNEL INHIBITOR.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  7044 MW;  17210 CN;
     RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT ECCKGDRCNK        60
//

ID   TXF2_DENPO     STANDARD;      PRT;    60 AA.
AC   P01414;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   TOXIN FS-2.
OS   DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77225275
RA   STRYDOM D.J.;
RL   EUR. J. BIOCHEM. 76:99-106(1977).
CC   -!- LD(50) IS 8 MG/KG BY SUBCUTANEOUS INJECTION.
CC   -!- SIMILARITY: STRONG, TO CALCISEPTINE.
DR   PIR; A01684; T6EP3D.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     22       BY SIMILARITY.
FT   DISULFID     17     39       BY SIMILARITY.
FT   DISULFID     41     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  7026 MW;  17298 CN;
     RICYSHKASL PRATKTCVEN TCYKMFIRTH RQYISERGCG CPTAMWPYQT ECCKGDRCNK        60
//

ID   TXF7_DENAN     STANDARD;      PRT;    61 AA.
AC   P01403;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   FASCICULIN I (ACETYLCHOLINESTERASE TOXIN F-VII) (TOXIN TA1).
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   73215577
RA   VILJOEN C.C., BOTES D.P.;
RL   J. BIOL. CHEM. 248:4915-4919(1973).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RM   93054489
RA   LE DU M.H., MARCHOT P., BOUGIS P.E., FONTECILLA-CAMPS J.C.;
RL   J. BIOL. CHEM. 267:22122-22130(1992).
CC   -!- FUNCTION: INHIBITS ACETYLCHOLINESTERASE. THE WHOLE VENOM HAS
CC       ANTICOAGULANT ACTIVITY, AND THE VARIOUS COMPONENTS SEEM TO ACT
CC       SYNERGISTICALLY.
CC   -!- LD(50) IS >20 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01674; T4EP1A.
DR   PDB; 1FAS; 31-OCT-93.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN; 3D-STRUCTURE.
FT   DISULFID      3     22
FT   DISULFID     17     39
FT   DISULFID     41     52
FT   DISULFID     53     59
FT   VARIANT      47     47       N -> Y.
SQ   SEQUENCE   61 AA;  6758 MW;  18412 CN;
     TMCYSHTTTS RAILTNCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDNLEV KCCTSPDKCN        60
     Y                                                                        61
//

ID   TXF8_DENAN     STANDARD;      PRT;    81 AA.
AC   P01404;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   TOXIN F-VIII PRECURSOR (TOXIN TA2) (TOXIN DAF8).
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RA   DUCANCEL F.;
RL   SUBMITTED (JUN-1990) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [2]
RP   SEQUENCE OF 22-81.
RC   TISSUE=VENOM;
RM   74070661
RA   VILJOEN C.C., BOTES D.P.;
RL   J. BIOL. CHEM. 249:366-372(1974).
CC   -!- FUNCTION: ITS PHARMACOLOGICAL ACTION IS UNKNOWN. IT PROBABLY ACTS
CC       SYNERGISTICALLY WITH OTHER VENOM COMPONENTS AS WHOLE VENOM IS VERY
CC       TOXIC.
CC   -!- LD(50) IS >250 MG/KG BY SUBCUTANEOUS INJECTION.
DR   EMBL; X53409; DADAF8.
DR   PIR; A01675; T5EP2A.
DR   PIR; S21299; S21299.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     81       TOXIN F-VIII.
FT   DISULFID     24     43       BY SIMILARITY.
FT   DISULFID     38     60       BY SIMILARITY.
FT   DISULFID     62     73       BY SIMILARITY.
FT   DISULFID     74     79       BY SIMILARITY.
FT   CONFLICT     54     54       I -> V (IN REF. 2).
SQ   SEQUENCE   81 AA;  8849 MW;  32586 CN;
     MKTLLLTLLV VTIVCLDLAS TMICYSHKTP QPSATITCEE KTCYKKSVRK LPAIVAGRGC        60
     GCPSKEMLVA IHCCRSDKCN E                                                  81
//

ID   TXM2_DENAN     STANDARD;      PRT;    86 AA.
AC   P18328;
DT   01-NOV-1990 (REL. 16, CREATED)
DT   01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   MUSCARINIC TOXIN 2 PRECURSOR.
OS   DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=VENOM GLAND;
RM   91320365
RA   DUCANCEL F., ROWAN E.G., CASSAR E., HARVEY A.L., MENEZ A.,
RA   BOULAIN J.-C.;
RL   TOXICON 29:516-520(1991).
RN   [2]
RP   SEQUENCE OF 22-86.
RC   TISSUE=VENOM;
RM   91320366
RA   KARLSSON E., RISINGER C., JOLKKONEN M., WERNSTEDT C., ADEM A.;
RL   TOXICON 29:521-526(1991).
CC   -!- FUNCTION: BINDS TO THE MUSCARINIC ACETYLCHOLINE RECEPTOR.
DR   EMBL; X52292; DATM1.
DR   PIR; A37910; A37910.
DR   PIR; A37911; A37911.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; NEUROTOXIN; SIGNAL.
FT   SIGNAL        1     21
FT   CHAIN        22     86       MUSCARINIC TOXIN 2.
FT   DISULFID     24     45       BY SIMILARITY.
FT   DISULFID     38     63       BY SIMILARITY.
FT   DISULFID     67     78       BY SIMILARITY.
FT   DISULFID     79     84       BY SIMILARITY.
SQ   SEQUENCE   86 AA;  9375 MW;  35965 CN;
     MKTLLLTLVV VTIVCLDLGY TLTCVTTKSI GGVTTEDCPA GQNVCFKRWH YVTPKNYDII        60
     KGCAATCPKV DNNDPIRCCG TDKCND                                             86
//

ID   TXW0_NAJNI     STANDARD;      PRT;    65 AA.
AC   P25680;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-10.
OS   NAJA NIVEA (CAPE COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80202933
RA   JOUBERT F.J., TALJAARD N.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:425-436(1980).
CC   -!- LD(50) IS 16 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7545 MW;  19216 CN;
     LRCLNCPEVF CRNFHTCRNG EKICFKRFDQ RKLLGKRYTR GCAVTCPVAK PREIVECCST        60
     DGCNR                                                                    65
//

ID   TXW1_NAJHH     STANDARD;      PRT;    65 AA.
AC   P01401;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-11.
OS   NAJA HAJE HAJE (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79045337
RA   JOUBERT F.J., TALJAARD N.;
RL   EUR. J. BIOCHEM. 90:359-367(1978).
CC   -!- LD(50) IS 13.4 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01672; V6NJ1Y.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7546 MW;  18060 CN;
     LTCLICPEKY CNKVHTCRNG ENQCFKRFNE RKLLGKRYTR GCAATCPEAK PREIVECCTT        60
     DRCNK                                                                    65
//

ID   TXW1_OPHHA     STANDARD;      PRT;    60 AA.
AC   P01412;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN DE-1.
OS   OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77226507
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:565-574(1977).
CC   -!- LD(50) IS >250 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01682; V7OH1D.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     23       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     42     52       BY SIMILARITY.
FT   DISULFID     53     58       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6812 MW;  17395 CN;
     LICFNQETYR PETTTTCPDG ENCYSTFWHN DGHVKIERGC GCPRVNPPIS ICCKTDKCNN        60
//

ID   TXW2_NAJHH     STANDARD;      PRT;    61 AA.
AC   P01415;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-2.
OS   NAJA HAJE HAJE (EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   79045337
RA   JOUBERT F.J., TALJAARD N.;
RL   EUR. J. BIOCHEM. 90:359-367(1978).
CC   -!- LD(50) IS 16.1 MG/KG BY SUBCUTANEOUS INJECTION.
DR   PIR; A01685; T2NJ2Y.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     37       BY SIMILARITY.
FT   DISULFID     41     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  7033 MW;  16901 CN;
     FTCFTTPSDT SETCPDGQNI CYEKRWNSHQ GVEIKGCVAS CPEFESRFRY LLCCRIDNCN        60
     K                                                                        61
//

ID   TXW3_NAJHA     STANDARD;      PRT;    60 AA.
AC   P25677;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-3.
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77163918
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:377-390(1977).
CC   -!- LD(50) IS 16.6 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     19       BY SIMILARITY.
FT   DISULFID     12     36       BY SIMILARITY.
FT   DISULFID     40     48       BY SIMILARITY.
FT   DISULFID     49     54       BY SIMILARITY.
SQ   SEQUENCE   60 AA;  6751 MW;  17345 CN;
     LECYQMSKVV TCKPEEKFCY SDVFMPFRNH VYTSGCSSYC RDGTGEKCCT TDRCNGARGG        60
//

ID   TXW4_NAJME     STANDARD;      PRT;    65 AA.
AC   P01400;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN S4C11.
OS   NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76019092
RA   CARLSSON F.H.H.;
RL   BIOCHIM. BIOPHYS. ACTA 400:310-321(1975).
CC   -!- LD(50) IS >20 MG/KG BY INTRAVENOUS INJECTION.
CC   -!- THE GEOGRAPHICAL LOCATION FOR THIS FOREST COBRA POPULATION WAS
CC       RHODESIA.
DR   PIR; A01671; V6NJ4W.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7430 MW;  18802 CN;
     LTCLICPEKY CNKVHTCRNG ENICFKRFYE GNLLGKRYPR GCAATCPEAK PREIVECCST        60
     DKCNH                                                                    65
//

ID   TXW5_NAJNA     STANDARD;      PRT;    62 AA.
AC   P29179;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK NEUROTOXIN 5.
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91285111
RA   SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL   FEBS LETT. 284:70-72(1991).
DR   PIR; S15871; S15871.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     40       BY SIMILARITY.
FT   DISULFID     44     54       BY SIMILARITY.
FT   DISULFID     55     60       BY SIMILARITY.
SQ   SEQUENCE   62 AA;  6943 MW;  18560 CN;
     LTCLICPEKY CNKVHTCLNG ENICFKRFNR ILGKRYDLGC AATCPTVKTG IVQCCSTDKC        60
     NH                                                                       62
//

ID   TXW6_NAJNA     STANDARD;      PRT;    65 AA.
AC   P29180;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK NEUROTOXIN 6.
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91285111
RA   SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL   FEBS LETT. 284:70-72(1991).
DR   PIR; S16019; S16019.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7568 MW;  19871 CN;
     LTCLICPEKY CNKVHTCLNG EKICFKRYSE RKLLGKRYIR GCADTCPVRK PREIVQCCST        60
     DKCNH                                                                    65
//

ID   TXW7_NAJNA     STANDARD;      PRT;    65 AA.
AC   P29181;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK NEUROTOXIN 7.
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91285111
RA   SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL   FEBS LETT. 284:70-72(1991).
DR   PIR; S16020; S16020.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7637 MW;  17274 CN;
     LTCLNCPEVY CRRFQICRDG EKICFKKFDQ RNLLGKRYRR GCAATCPEAK PREIVQCCST        60
     DKCNR                                                                    65
//

ID   TXW8_NAJNA     STANDARD;      PRT;    65 AA.
AC   P29182;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK NEUROTOXIN 8.
OS   NAJA NAJA (INDIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   91285111
RA   SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL   FEBS LETT. 284:70-72(1991).
DR   PIR; S16021; S16021.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7581 MW;  17802 CN;
     LTCLNCPEVY CRRFQKCRNG EKICFKKFDQ RNLLGKRYEI GCAATCPEAK PREIVQCCST        60
     DKCNR                                                                    65
//

ID   TXW9_NAJKA     STANDARD;      PRT;    64 AA.
AC   P25679;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-9A.
OS   NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80202933
RA   JOUBERT F.J., TALJAARD N.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:425-436(1980).
CC   -!- LD(50) IS 82 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     41       BY SIMILARITY.
FT   DISULFID     45     56       BY SIMILARITY.
FT   DISULFID     57     62       BY SIMILARITY.
SQ   SEQUENCE   64 AA;  7493 MW;  19004 CN;
     LRCLNCPEMF CGKFQICRNG EKICFKKLHQ RRPLSRYIRG CADTCPVGYP KEMIECCSTD        60
     KCNR                                                                     64
//

ID   TXWA_NAJHA     STANDARD;      PRT;    61 AA.
AC   P25678;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-2A.
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   77163918
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:377-390(1977).
CC   -!- LD(50) IS 15.4 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     19       BY SIMILARITY.
FT   DISULFID     12     37       BY SIMILARITY.
FT   DISULFID     41     49       BY SIMILARITY.
FT   DISULFID     50     55       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6837 MW;  18024 CN;
     LECYQMSKVV TCKPEETFCY SDVFMPFRNH IVYTSGCSSY CRDGTGEKCC TTDRCNGARG        60
     G                                                                        61
//

ID   TXWB_HEMHA     STANDARD;      PRT;    57 AA.
AC   P01402;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-1B.
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   80236878
RA   JOUBERT F.J., TALJAARD N.;
RL   TOXICON 18:191-198(1980).
CC   -!- LD(50) IS 11.7 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01673; T2NJBE.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     19       BY SIMILARITY.
FT   DISULFID     12     37       BY SIMILARITY.
FT   DISULFID     40     49       BY SIMILARITY.
FT   DISULFID     50     55       BY SIMILARITY.
SQ   SEQUENCE   57 AA;  6630 MW;  16557 CN;
     LECYQKSKVV TCQPEQKFCY SDTMTFFPNH PVYLSGCTFC RTDESGERCC TTDRCNK           57
//

ID   TXWB_NAJHA     STANDARD;      PRT;    65 AA.
AC   P01399;
DT   21-JUL-1986 (REL. 01, CREATED)
DT   21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT   01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-13B.
OS   NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RM   76119554
RA   JOUBERT F.J.;
RL   HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:1901-1908(1975).
CC   -!- LD(50) IS 4.82 MG/KG BY INTRAVENOUS INJECTION.
DR   PIR; A01670; V6NJ3E.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     24       BY SIMILARITY.
FT   DISULFID      6     11       BY SIMILARITY.
FT   DISULFID     17     42       BY SIMILARITY.
FT   DISULFID     46     57       BY SIMILARITY.
FT   DISULFID     58     63       BY SIMILARITY.
SQ   SEQUENCE   65 AA;  7592 MW;  18555 CN;
     LTCFNCPEVY CNRFHTCRNG EKICFKRFNE RKLLGKRYTR GCAATCPVAK PREIVECCST        60
     DRCNH                                                                    65
//

ID   TXWC_HEMHA     STANDARD;      PRT;    61 AA.
AC   P25676;
DT   01-MAY-1992 (REL. 22, CREATED)
DT   01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT   01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE   WEAK TOXIN CM-1C.
OS   HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC   LEPIDOSAURIA; SERPENTES.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RA   JOUBERT F.J., TALJAARD N.;
RL   S. AFR. J. CHEM. 32:73-77(1979).
CC   -!- LD(50) IS 54 MG/KG BY INTRAVENOUS INJECTION.
DR   PROSITE; PS00272; SNAKE_TOXIN.
KW   VENOM; TOXIN.
FT   DISULFID      3     21       BY SIMILARITY.
FT   DISULFID     14     37       BY SIMILARITY.
FT   DISULFID     41     53       BY SIMILARITY.
FT   DISULFID     54     59       BY SIMILARITY.
SQ   SEQUENCE   61 AA;  6917 MW;  17835 CN;
     FTCFTTPSDT SETCPIGNNI CYEKRWSGHG MQIEKGCVAS CPSFESHYKF LLCCRIENCN        60
     Q                                                                        61
//