Sequences in Snake Toxin family
ID CX10_NAJHA STANDARD; PRT; 60 AA.
AC P01453;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 10 (TOXIN CM-4A).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117444
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC -!- LD(50) IS 4.14 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01718; H3NJ0E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6682 MW; 19277 CN;
LECNQLIPIA HKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKNSALVK YVCCNTDRCN 60
//
ID CX11_NAJHA STANDARD; PRT; 62 AA.
AC P01472;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 11 (TOXIN CM-13A) (TOXIN CM-12).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA), AND NAJA HAJE HAJE
OS (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP CM-13A, SEQUENCE.
RC SPECIES=N.H.ANNULIFERA; TISSUE=VENOM;
RM 76210208
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 64:219-232(1976).
RN [2]
RP CM-12, SEQUENCE, AND REVISIONS TO 53-62 OF CM-13A.
RC SPECIES=N.H.HAJE; TISSUE=VENOM;
RM 79045337
RA JOUBERT F.J., TALJAARD N.;
RL EUR. J. BIOCHEM. 90:359-367(1978).
CC -!- LD(50) IS 25.2 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01732; H3NJZE.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6842 MW; 20410 CN;
LKCHNTQLPF IYKTCPEGKN LCFKTTLKKL PLKIPIKRGC AATCPKSSAL LKVVCCSTDK 60
CN 62
//
ID CX1_HEMHA STANDARD; PRT; 61 AA.
AC P01471;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (HEMOLYTIC PROTEIN 12B).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 73140212
RA FRYKLUND L., EAKER D.;
RL BIOCHEMISTRY 12:661-667(1973).
CC -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC AND HYPOTENSIVE ACTIVITIES.
DR PIR; A01731; H3RI1L.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6844 MW; 19920 CN;
LKCHNKLVPF LSKTCPEGKN LCYKMTMLKM PKIPIKRGCT DACPKSSLLV KVVCCNKDKC 60
N 61
//
ID CX1_NAJAT STANDARD; PRT; 60 AA.
AC P01449; P01450;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (CARDIOTOXIN F8) (CYTOTOXIN CM-6) (CARDIOTOXIN-ANALOGUE
DE I).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS), AND
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC SPECIES=N.ATRA; TISSUE=VENOM;
RM 75204890
RA HAYASHI K., TAKECHI M., SASAKI T., LEE C.Y.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 64:360-366(1975).
RN [2]
RP SEQUENCE.
RC SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM 75205551
RA FRYKLUND L., EAKER D.;
RL BIOCHEMISTRY 14:2860-2865(1975).
RN [3]
RP SEQUENCE.
RC SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM 88209578
RA OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
CC -!- LD(50) IS 2.8 MG/KG BY INTRAPERITONEAL INJECTION AND 0.75 MG/KG BY
CC INTRAVENOUS INJECTION.
CC -!- CAUTION: THE SEQUENCE OF N.ATRA IN POSITION 45-46 WAS SHOWN AS
CC SER-ASN IN REF.1 AND REVISED TO ASN-SER IN REF.3.
DR PIR; A01715; H3NJ1F.
DR PIR; A90389; H3NJ1K.
DR PIR; JS0057; JS0057.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6701 MW; 18732 CN;
LKCNKLIPIA SKTCPAGKNL CYKMFMMSDL TIPVKRGCID VCPKNSLLVK YVCCNTDRCN 60
//
ID CX1_NAJHA STANDARD; PRT; 60 AA.
AC P01455;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (TOXIN V-II-1).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75059100
RA WEISE K.H.K., CARLSSON F.H.H., JOUBERT F.J., STRYDOM D.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 354:1317-1326(1973).
CC -!- LD(50) IS 3 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01720; H3NJ1E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6696 MW; 21040 CN;
LKCHKLVPPV WKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKNSALVK YVCCSTDKCN 60
//
ID CX1_NAJME STANDARD; PRT; 60 AA.
AC P01448;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (CYTOTOXIN V-II-1).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA CARLSSON F.H.H., JOUBERT F.J.;
RL BIOCHIM. BIOPHYS. ACTA 336:453-469(1974).
CC -!- LD(50) IS 1.37 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01714; H3NJ1W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 1 1 L -> I (IN EQUAL AMOUNT).
SQ SEQUENCE 60 AA; 6682 MW; 19858 CN;
LECNKLVPIA HKTCPAGKNL CYQMYMVSKS TIPVKRGCID VCPKSSLLVK YVCCNTDRCN 60
//
ID CX1_NAJMO STANDARD; PRT; 60 AA.
AC P01467;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (CARDIOTOXIN XIIB) (CYTOTOXIN V-II-1) (CTX IIB).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA LOUW A.I.;
RL BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
RN [2]
RP STRUCTURE BY NMR.
RM 88029481
RA OTTING G., STEINMETZ W.E., BOUGIS P.E., ROCHAT H., WUETHRICH K.;
RL EUR. J. BIOCHEM. 168:609-620(1987).
RN [3]
RP STRUCTURE BY NMR.
RM 93279339
RA O'CONNELL J.F., BOUGIS P.E., WUETHRICH K.;
RL EUR. J. BIOCHEM. 213:891-900(1993).
CC -!- LD(50) IS 0.83 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01728; H3NJ1M.
DR PIR; S02517; S02517.
DR PDB; 2CCX; 31-JAN-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 21
FT DISULFID 14 38
FT DISULFID 42 53
FT DISULFID 54 59
SQ SEQUENCE 60 AA; 6826 MW; 18916 CN;
LKCNQLIPPF WKTCPKGKNL CYKMTMRAAP MVPVKRGCID VCPKSSLLIK YMCCNTNKCN 60
//
ID CX1_NAJNA STANDARD; PRT; 60 AA.
AC P01447;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (CYTOTOXIN XI).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72086694
RA HAYASHI K., TAKECHI M., SASAKI T.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 45:1357-1362(1971).
DR PIR; A01713; H3NJ1I.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6791 MW; 18724 CN;
LKCNKLIPLA YKTCPAGKNL CYKMYMVSNK TVPVKRGCID VCPKNSLVLK YECCNTDRCN 60
//
ID CX1_NAJNI STANDARD; PRT; 60 AA.
AC P01456;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (TOXIN V-II-1).
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77022157
RA BOTES D.P., VILJOEN C.C.;
RL BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC -!- LD(50) IS 2.9 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; B01722; H3NJ1C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6697 MW; 21085 CN;
LKCHKLVPPV WKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKDSALVK YVCCSTDKCN 60
//
ID CX1_NAJOX STANDARD; PRT; 60 AA.
AC P01451;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1.
OS NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA GRISHIN E.V., SUKHIKH A.P., ADAMOVICH T.B., OVCHINNIKOV Y.A.;
RL BIOORG. KHIM. 2:1018-1034(1976).
DR PIR; A01716; H3NJ1R.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6821 MW; 18931 CN;
LKCNKLVPIA YKTCPEGKNL CYKMFMMSDL TIPVKRGCID VCPKNSLLVK YVCCNTDRCN 60
//
ID CX1_NAJPA STANDARD; PRT; 60 AA.
AC P01468;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 1 (CARDIOTOXIN GAMMA).
OS NAJA PALLIDA (RED SPITTING COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE, AND DISULFIDE BONDS.
RC TISSUE=VENOM;
RM 75205552
RA FRYKLUND L., EAKER D.;
RL BIOCHEMISTRY 14:2865-2871(1975).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS).
RM 94254084
RA BILWES A., REES B., MORAS D., MENEZ R., MENEZ A.;
RL J. MOL. BIOL. 239:122-136(1994).
CC -!- CAUTION: THE VENOM OF THIS SNAKE WAS ORIGINALLY THOUGHT TO BE THAT
CC OF N.NIGRICOLLIS.
DR PIR; A37578; H3NJ1B.
DR PDB; 1TGX; 30-APR-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 21
FT DISULFID 14 38
FT DISULFID 42 53
FT DISULFID 54 59
SQ SEQUENCE 60 AA; 6827 MW; 18973 CN;
LKCNQLIPPF WKTCPKGKNL CYKMTMRAAP MVPVKRGCID VCPKSSLLIK YMCCNTDKCN 60
//
ID CX1_NAJSP STANDARD; PRT; 81 AA.
AC Q02454;
DT 01-FEB-1994 (REL. 28, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE CARDIOTOXIN PRECURSOR.
GN CTX.
OS NAJA SPUTATRIX (MALAYAN SPITTING COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 93190317
RA YEO M.S., JEYASEELAN K., CHUNG M.C., GOPALAKRISHNAKONE P.,
RA TAN C.H., WONG H.A.;
RL TOXICON 31:53-60(1993).
DR EMBL; L04640; NNCRDTXN.
DR EMBL; S55947; S55947.
DR PIR; A44335; A44335.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 81 CARDIOTOXIN.
FT DISULFID 24 42 BY SIMILARITY.
FT DISULFID 35 59 BY SIMILARITY.
FT DISULFID 63 74 BY SIMILARITY.
FT DISULFID 75 80 BY SIMILARITY.
SQ SEQUENCE 81 AA; 9098 MW; 37274 CN;
MKTLLLTTVV VTIVCLDLEY TLKCNKLVPL FYKTCPAGKN LCYKMFMVAT PKVPVKRGCI 60
DVCPKSSLLV KYVCCNTDRC N 81
//
ID CX2_HEMHA STANDARD; PRT; 61 AA.
AC P24776;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (TOXIN 12A).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77162036
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 74:387-396(1977).
CC -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC AND HYPOTENSIVE ACTIVITIES.
CC -!- LD(50) IS 3.8 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6800 MW; 20126 CN;
LKCHNKVVPF LSKTCPEGKN LCYKMTLKKV PKIPIKRGCT DACPKSSLLV NVMCCKTDKC 60
N 61
//
ID CX2_NAJAT STANDARD; PRT; 60 AA.
AC P01442;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (CARDIOTOXIN ANALOGUE II).
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77134916
RA KANEDA N., SASAKI T., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 491:53-66(1977).
CC -!- LD(50) IS 2.1 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01710; H3NJ2F.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6750 MW; 18984 CN;
LKCNKLVPLF YKTCPAGKNL CYKMFMVSNL TVPVKRGCID VCPKNSALVK YVCCNTDRCN 60
//
ID CX2_NAJHA STANDARD; PRT; 60 AA.
AC P01462;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (TOXINS V-II-2 AND V-II-2A).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76119553
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:1893-1900(1975).
CC -!- LD(50) IS 1.98 MG/KG BY INTRAVENOUS INJECTION.
CC -!- THE SEQUENCE OF THE MAJOR COMPONENT IS SHOWN, IT IS CALLED TOXIN
CC V-II-2 AND THE MINOR COMPONENT IS CALLED TOXIN V-II-2A.
DR PIR; A01725; H3NJ2E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 52 52 M -> V (IN TOXIN V-II2A).
FT VARIANT 55 55 N -> S (IN TOXIN V-II2A).
SQ SEQUENCE 60 AA; 6858 MW; 19209 CN;
LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCID VCPKDSALVK YMCCNTDKCN 60
//
ID CX2_NAJKA STANDARD; PRT; 60 AA.
AC P01445;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (CYTOTOXIN CM-7A).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 81154155
RA JOUBERT F.J., TALJAARD N.;
RL TOXICON 18:455-467(1980).
CC -!- LD(50) IS 1.2 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01712; H3NJ2K.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6745 MW; 19284 CN;
LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID VCPKNSLLVK YVCCNTDRCN 60
//
ID CX2_NAJME STANDARD; PRT; 61 AA.
AC P01474;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (CYTOTOXINS V-II-2 AND V-II-3).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74275121
RA CARLSSON F.H.H.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 59:269-276(1974).
CC -!- THESE TWO SEQUENCES HAVE G & L AT POSITIONS 25 & 27, RESPECTIVELY,
CC INSTEAD OF 2 MET THAT ARE FOUND IN MOST OTHER CYTOTOXINS & CARDIO-
CC TOXINS. THE LOW TOXICITY OF THESE 2 PROTEINS MAY POSSIBLY BE CORR-
CC ELATED WITH THESE CHANGES.
CC -!- LD(50) IS 6.25 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01734; H3NJ2W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
FT VARIANT 36 36 N -> K (IN V-II-3).
SQ SEQUENCE 61 AA; 6850 MW; 19921 CN;
IKCHNTLLPF IYKTCPEGQN LCFKGTLKFP KKTTYNRGCA ATCPKSSLLV KYVCCNTNKC 60
N 61
//
ID CX2_NAJMO STANDARD; PRT; 60 AA.
AC P01469;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (CARDIOTOXIN XIIA) (CYTOTOXIN V-II-2).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA LOUW A.I.;
RL BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
RN [2]
RP STRUCTURE BY NMR.
RM 88029481
RA OTTING G., STEINMETZ W.E., BOUGIS P.E., ROCHAT H., WUETHRICH K.;
RL EUR. J. BIOCHEM. 168:609-620(1987).
CC -!- LD(50) IS 1.11 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01729; H3NJ2M.
DR PIR; S02518; S02518.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6800 MW; 19168 CN;
LKCNQLIPPF WKTCPKGKNL CYKMTMRGAS KVPVKRGCID VCPKSSLLIK YMCCNTDKCN 60
//
ID CX2_NAJNA STANDARD; PRT; 60 AA.
AC P01440;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (CYTOTOXIN II).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72261302
RA TAKECHI M., HAYASHI K., SASAKI T.;
RL MOL. PHARMACOL. 8:446-451(1972).
RN [2]
RP DISULFIDE BONDS.
RM 73060175
RA TAKECHI M., HAYASHI K.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 49:584-590(1972).
DR PIR; A01708; H3NJ2I.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21
FT DISULFID 14 38
FT DISULFID 42 53
FT DISULFID 54 59
SQ SEQUENCE 60 AA; 6763 MW; 20106 CN;
LKCNKLVPLF YKTCPAGKNL CYKMYMVATP KVPVKRGCID VCPKSSLVLK YVCCNTDRCN 60
//
ID CX2_NAJNI STANDARD; PRT; 60 AA.
AC P01463;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2 (TOXIN V-II-2).
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77022157
RA BOTES D.P., VILJOEN C.C.;
RL BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC -!- LD(50) IS 1.5 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01726; H3NJ2C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6871 MW; 19032 CN;
LKCHQLIPPF WKTCPEGKNL CYKMYMVATP MIPVKRGCID VCPKNSALVK YMCCNTDKCN 60
//
ID CX2_NAJOX STANDARD; PRT; 60 AA.
AC P01441;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 2.
OS NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75058179
RA GRISHIN E.V., SUKHIKH A.P., ADAMOVICH T.B., OVCHINNIKOV Y.A.,
RA YUKELSON L.Y.;
RL FEBS LETT. 48:179-183(1974).
DR PIR; A01709; H3NJ2R.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6636 MW; 20016 CN;
LKCKKLVPLF SKTCPAGKNL CYKMFMVAAP HVPVKRGCID VCPKSSLLVK YVCCNTDKCN 60
//
ID CX3_HEMHA STANDARD; PRT; 61 AA.
AC P24777;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (TOXINS 11 AND 11A).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77162036
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 74:387-396(1977).
CC -!- FUNCTION: THIS PROTEIN LYSES RED BLOOD CELLS AND HAS CARDIOTOXIC
CC AND HYPOTENSIVE ACTIVITIES.
CC -!- LD(50) IS 2.5 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
FT VARIANT 10 10 F -> Y (IN TOXIN 11A).
SQ SEQUENCE 61 AA; 6793 MW; 21576 CN;
LKCHNKLVPF LSKTCPDGKN LCYKMSMEVT PMIPIKRGCT DTCPKSSLLV KVVCCKTDKC 60
N 61
//
ID CX3_NAJAT STANDARD; PRT; 60 AA.
AC P01444;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (CARDIOTOXIN ANALOGUE III) (CTX III) (CARDIOTOXIN C-10)
DE (CYTOTOXIN IV).
OS NAJA ATRA (CHINESE COBRA), AND NAJA NAJA KAOUTHIA (MONOCLED
OS COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE, AND REVISION.
RC SPECIES=N.ATRA; TISSUE=VENOM;
RM 76257817
RA HAYASHI K., TAKECHI M., KANEDA N., SASAKI T.;
RL FEBS LETT. 66:210-214(1976).
RN [2]
RP SEQUENCE.
RC SPECIES=N.ATRA; TISSUE=VENOM;
RM 71211413
RA NARITA K., LEE C.Y.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 41:339-343(1970).
RN [3]
RP SEQUENCE.
RC SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM 90035789
RA CHIOU S.-H., LIN W.-W., CHANG W.-P.;
RL INT. J. PEPT. PROTEIN RES. 34:148-152(1989).
RN [4]
RP SEQUENCE.
RC SPECIES=N.N.KAOUTHIA; TISSUE=VENOM;
RM 88209578
RA OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
RN [5]
RP STRUCTURE BY NMR.
RM 94141922
RA BHASKARAN R., HUANG C.C., CHANG D.K., YU C.;
RL J. MOL. BIOL. 235:1291-1301(1994).
CC -!- LD(50) IS 1.48 MG/KG BY INTRAPERITONEAL INJECTION.
CC -!- CAUTION: THIS TOXIN IS KNOWN AS CYTOTOXIN 3 IN N.ATRA AND
CC CYTOTOXIN IV IN N.N.KAOUTHIA.
DR PIR; A01711; H3NJ3F.
DR PIR; JK0222; JK0222.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6747 MW; 19990 CN;
LKCNKLVPLF YKTCPAGKNL CYKMFMVATP KVPVKRGCID VCPKSSLLVK YVCCNTDRCN 60
//
ID CX3_NAJHA STANDARD; PRT; 60 AA.
AC P01459;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (TOXINS CM-8 AND CM-8A).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76210208
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 64:219-232(1976).
CC -!- THE SEQUENCE OF THE MAJOR COMPONENT IS SHOWN, IT IS CALLED TOXIN
CC CM-8 AND THE MINOR COMPONENT IS CALLED TOXIN CM-8A.
CC -!- LD(50) IS 2.98 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01723; H3NJ3E.
DR PIR; B01723; H3NJME.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 4 4 Y -> H (IN TOXIN CM-8A).
SQ SEQUENCE 60 AA; 6839 MW; 20280 CN;
LKCYKLVPPF WKTCPEGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTDKCN 60
//
ID CX3_NAJKA STANDARD; PRT; 60 AA.
AC P01446;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (CYTOTOXIN CM-7).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 81154155
RA JOUBERT F.J., TALJAARD N.;
RL TOXICON 18:455-467(1980).
RN [2]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88209578
RA OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
CC -!- LD(50) IS 1.2 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; B01712; H3NJ3K.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6717 MW; 18505 CN;
LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID ACPKNSLLVK YVCCNTDRCN 60
//
ID CX3_NAJME STANDARD; PRT; 61 AA.
AC P01473;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (COMPONENT 3.20).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76022477
RA SHIPOLINI R.A., KISSONERGHIS M., BANKS B.E.C.;
RL EUR. J. BIOCHEM. 56:449-454(1975).
CC -!- LD(50) IS 12 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A01733; H3NJ3W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6833 MW; 19060 CN;
IKCHNTPLPF IYKTCPEGNN LCFKGTLKFP KKITYKRGCA DACPKTSALV KYVCCNTDKC 60
N 61
//
ID CX3_NAJMO STANDARD; PRT; 60 AA.
AC P01470;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (CYTOTOXIN V-II-3).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA LOUW A.I.;
RL BIOCHIM. BIOPHYS. ACTA 336:481-495(1974).
CC -!- LD(50) IS 1.82 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01730; H3NJ3M.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6894 MW; 19065 CN;
LKCNRLIPPF WKTCPEGKNL CYKMTMRLAP KVPVKRGCID VCPKSSLLIK YMCCNTNKCN 60
//
ID CX3_NAJNA STANDARD; PRT; 60 AA.
AC P24780;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (CYTOTOXIN IIA).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 85121947
RA KANEDA N., TAKECHI M., SASAKI T., HAYASHI K.;
RL BIOCHEM. INT. 9:603-610(1984).
CC -!- LD(50) IS 40 TO 55 MG/KG BY SUBCUTANEOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6745 MW; 19275 CN;
LKCNKLIPLA YKTCPAGKNL CYKMFMVSNK TVPVKRGCID VCPKNSLVLK YVCCNTDRCN 60
//
ID CX3_NAJNI STANDARD; PRT; 60 AA.
AC P01458;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 3 (TOXIN V-II-3).
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77022157
RA BOTES D.P., VILJOEN C.C.;
RL BIOCHIM. BIOPHYS. ACTA 446:1-9(1976).
CC -!- LD(50) IS 1.6 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01722; H3NJ3C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6791 MW; 19559 CN;
LKCNQLIPPF WKTCPKGKNL CYNMYMVSTS TVPVKRGCID VCPKNSALVK YVCCNTDRCN 60
//
ID CX4_NAJAT STANDARD; PRT; 60 AA.
AC P01443;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 4 (CARDIOTOXIN ANALOGUE IV).
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77134916
RA KANEDA N., SASAKI T., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 491:53-66(1977).
CC -!- LD(50) IS 2.1 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; B01710; H3NJ4F.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6793 MW; 18975 CN;
RKCNKLVPLF YKTCPAGKNL CYKMFMVSNL TVPVKRGCID VCPKNSALVK YVCCNTDRCN 60
//
ID CX4_NAJHA STANDARD; PRT; 60 AA.
AC P01461;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 4 (TOXIN CM-11).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76210208
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 64:219-232(1976).
CC -!- LD(50) IS 4.0 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01724; H3NJ4E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6802 MW; 20169 CN;
LKCNKLIPPF WKTCPKGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTNKCN 60
//
ID CX4_NAJMO STANDARD; PRT; 60 AA.
AC P01452;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 4 (CARDIOTOXIN V-II-4).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74258253
RA LOUW A.I.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 58:1022-1029(1974).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
RM 90317830
RA REES B., BILWES A., SAMAMA J.-P., MORAS D.;
RL J. MOL. BIOL. 214:281-297(1990).
CC -!- LD(50) IS 1.97 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01717; H3NJ4M.
DR PDB; 1CDT; 15-JUL-91.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 21
FT DISULFID 14 38
FT DISULFID 42 53
FT DISULFID 54 59
FT STRAND 2 4
FT TURN 8 9
FT STRAND 11 13
FT TURN 16 17
FT STRAND 20 26
FT TURN 27 30
FT STRAND 32 39
FT STRAND 49 54
FT TURN 57 58
SQ SEQUENCE 60 AA; 6715 MW; 19123 CN;
LKCNKLIPIA YKTCPEGKNL CYKMMLASKK MVPVKRGCIN VCPKNSALVK YVCCSTDRCN 60
//
ID CX5_NAJAT STANDARD; PRT; 60 AA.
AC P07525;
DT 01-APR-1988 (REL. 07, CREATED)
DT 01-APR-1988 (REL. 07, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 5 (CYTOTOXIN D1) (MEMBRANE TOXIN D1).
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA WU W.Y., DU Y.C.;
RL ACTA BIOCHIM. BIOPHYS. SIN. 16:310-315(1984).
CC -!- FUNCTION: THIS TOXIN IS CARDIOTOXIC AND CYTOCIDIAL TO YOSHIDA
CC SARCOMA CELLS.
DR PIR; JC0001; H3NJ5F.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; CALCIUM CHANNEL INHIBITOR;
KW MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6810 MW; 19945 CN;
LKCNKLVPLF YKTCPAGKNL CYKMFMVSNK MVPVKRGCID VCPKSSLLVK YVCCNTDRCN 60
//
ID CX5_NAJHA STANDARD; PRT; 60 AA.
AC P01464;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 5 (TOXIN CM-6).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117466
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC -!- LD(50) IS 1.82 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01727; H3NJ5E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6856 MW; 19075 CN;
LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MIPVKRGCID VCPKNSALVK YMCCNTNKCN 60
//
ID CX5_NAJHH STANDARD; PRT; 60 AA.
AC P01457;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 5 (CYTOTOXIN CM-8).
OS NAJA HAJE HAJE (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 78211247
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 534:331-340(1978).
CC -!- LD(50) IS 2.6 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01721; H3NJ5Y.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6773 MW; 20331 CN;
LKCHQLVPPF WKTCPEGKNL CYKMYMVSSS TVPVKRGCID VCPKNSALVK YVCCNTDKCN 60
//
ID CX5_NAJKA STANDARD; PRT; 60 AA.
AC P24779;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 5 (CYTOTOXIN II).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88209578
RA OHKURA K., INOUE S., IKEDA K., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 954:148-153(1988).
DR PIR; JS0028; JS0028.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6654 MW; 17962 CN;
LKCNKLIPLA YKTCPAGKNL CYKMFMVAAP KVPVKRGCID ACPKNSLLVK YVCCNTDRCN 60
//
ID CX5_NAJMO STANDARD; PRT; 60 AA.
AC P25517;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-AUG-1992 (REL. 23, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 5 (CTX V).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 84013732
RA BOUGIS P.E., TESSIER M., VAN RIETSCHOTEN J., ROCHAT H., FAUCON J.F.,
RA DUFOURCQ J.;
RL MOL. CELL. BIOCHEM. 55:49-64(1983).
CC -!- LD(50) IS 2.85 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6817 MW; 19524 CN;
LKCKKLIPLF SKTCPEGKNL CYKMTMRLAP KVPVKRGCID VCPKSSFLVK YECCDTDKCN 60
//
ID CX6_NAJAT STANDARD; PRT; 60 AA.
AC P80245;
DT 01-FEB-1994 (REL. 28, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 6 (CARDIOTOXIN 6).
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 94251167
RA HUNG C.C., WU S.-H., CHIOU S.-H.;
RL BIOCHEM. MOL. BIOL. INT. 31:1831-1840(1993).
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6689 MW; 19252 CN;
LKCNQLIPPF YKTCAAGKNL CYKMFMVAAP KVPVKRGCID VCPKSSLLVK YVCCNTDRCN 60
//
ID CX6_NAJHA STANDARD; PRT; 60 AA.
AC P01465;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 6 (TOXIN CM-2H).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117466
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC -!- LD(50) IS 5.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; B01727; H3NJ6E.
DR PIR; C01727; H3NJ6M.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 52 52 M -> V (IN MINOR COMPONENT).
FT VARIANT 55 55 N -> S (IN MINOR COMPONENT).
SQ SEQUENCE 60 AA; 6857 MW; 19152 CN;
LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCID VCPKDSALVK YMCCNTNKCN 60
//
ID CX7_NAJHA STANDARD; PRT; 60 AA.
AC P01466;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 7 (TOXIN CM-4B).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117466
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:79-96(1977).
CC -!- LD(50) IS 2.61 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; D01727; H3NJ7E.
DR PIR; E01727; H3NJ7M.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 52 52 M -> V (IN MINOR COMPONENT).
FT VARIANT 55 55 N -> S (IN MINOR COMPONENT).
SQ SEQUENCE 60 AA; 6856 MW; 19112 CN;
LKCHKLVPPF WKTCPEGKNL CYKMYMVATP MLPVKRGCIN VCPKDSALVK YMCCNTNKCN 60
//
ID CX8_NAJHA STANDARD; PRT; 60 AA.
AC P01460;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 8 (TOXIN CM-7).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117444
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC -!- LD(50) IS 2.6 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A91669; H3NJ8E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6812 MW; 20183 CN;
LKCHKLVPPF WKTCPEGKNL CYKMYMVSTL TVPVKRGCID VCPKNSALVK YVCCNTNKCN 60
//
ID CX9_NAJHA STANDARD; PRT; 60 AA.
AC P01454;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CYTOTOXIN 9 (TOXIN CM-2E).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77117444
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 357:1735-1750(1976).
CC -!- LD(50) IS 4.9 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01719; H3NJ9E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 38 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6669 MW; 19422 CN;
LECNKLVPIA HKTCPEGKNL CYKMFMVSTS TVPVKRGCID VCPKDSALVK YVCCNTDRCN 60
//
ID CXH2_ASPSC STANDARD; PRT; 63 AA.
AC P19003;
DT 01-NOV-1990 (REL. 16, CREATED)
DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG S3C2.
OS ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88185648
RA JOUBERT F.J.;
RL INT. J. BIOCHEM. 20:337-345(1988).
CC -!- LD(50) IS 6.6 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; JS0298; JS0298.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
SQ SEQUENCE 63 AA; 7173 MW; 22113 CN;
RKCLNTPLPL FYKTCPEGKD LCYKMNFKLL PKKLSIKRGC TDTCPKSSLL VKVVCCDTDK 60
CNK 63
//
ID CXH4_ASPSC STANDARD; PRT; 64 AA.
AC P19004;
DT 01-NOV-1990 (REL. 16, CREATED)
DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG S4C8.
OS ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88185648
RA JOUBERT F.J.;
RL INT. J. BIOCHEM. 20:337-345(1988).
CC -!- LD(50) IS 9.4 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; JS0299; JS0299.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 62 BY SIMILARITY.
SQ SEQUENCE 64 AA; 7316 MW; 17810 CN;
RKCFNSPGRL VSKPCPEGNN LCYKMSNRMY PPGFNVRRGC AETCPRRNRL LEVVCCCDTD 60
NCNK 64
//
ID CXHA_MATBI STANDARD; PRT; 41 AA.
AC P24742;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG MATICOTOXIN A (FRAGMENT).
OS MATICORA BIVIRGATA (LONG-GLANDED CORAL SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91263097
RA TAKASAKI C., YOSHIDA H., SHIMAZU T., TERUUCHI T., TORIBA M.,
RA TAMIYA N.;
RL TOXICON 29:191-200(1991).
DR PIR; C39558; C39558.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT NON_TER 41 41
SQ SEQUENCE 41 AA; 4677 MW; 7983 CN;
LICYNTPFKD ISKTCAEGEN LCYYGKKDAV WNLYPIRGCA D 41
//
ID CXH_HEMHA STANDARD; PRT; 63 AA.
AC P24778;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG (TOXINS 9B AND 9BB).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77162036
RA JOUBERT F.J.;
RL EUR. J. BIOCHEM. 74:387-396(1977).
CC -!- FUNCTION: THIS TOXIN HAS A VERY LOW TOXICITY.
CC -!- LD(50) IS 33.5 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
FT VARIANT 37 37 K -> R (IN TOXIN 9BB).
SQ SEQUENCE 63 AA; 7193 MW; 20949 CN;
LICHNRPLPF LHKTCPEGQN ICYKMTLKKT PMKLSVKRGC AATCPSERPL VQVECCKTDK 60
CNW 63
//
ID CXH_NAJKA STANDARD; PRT; 62 AA.
AC P14541;
DT 01-JAN-1990 (REL. 13, CREATED)
DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG (CLBP).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 87247251
RA INOUE S., OHKURA K., IKEDA K., HAYASHI K.;
RL FEBS LETT. 218:17-21(1987).
CC -!- FUNCTION: LOW CYTOTOXIN ACTIVITY.
DR PIR; A27025; A27025.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6994 MW; 18960 CN;
LKCHNTQLPF IYKTCPEGKN LCFKATLKKF PLKIPIKRGC ADNCPKNSAL LKYVCCSTDK 60
CN 62
//
ID CXH_NAJNA STANDARD; PRT; 62 AA.
AC P14554;
DT 01-JAN-1990 (REL. 13, CREATED)
DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE CYTOTOXIN HOMOLOG (CLBP) (LESS-CYTOTOXIC BASIC POLYPEPTIDE) (LCBP)
DE (CARDIOTOXIN V) (CTX V).
OS NAJA NAJA (INDIAN COBRA), AND NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC SPECIES=N.NAJA, AND N.ATRA; TISSUE=VENOM;
RM 90060345
RA INOUE S., OKUMURA K., TSUJINO M., OHKURA K., IKEDA K., TAKECHI M.,
RA TANAKA Y., HAYASHI K.;
RL FEBS LETT. 257:319-323(1989).
RN [2]
RP SEQUENCE.
RC SPECIES=N.NAJA; TISSUE=VENOM;
RM 90184454
RA SHAFQAT J., ZAIDI Z.H., JOERNVALL H.;
RL FEBS LETT. 261:245-246(1990).
RN [3]
RP PRELIMINARY SEQUENCE.
RC SPECIES=N.ATRA; TISSUE=VENOM;
RM 86130665
RA TAKECHI M., TANAKA Y., HAYASHI K.;
RL BIOCHEM. INT. 11:795-802(1985).
RN [4]
RP PRELIMINARY SEQUENCE.
RC SPECIES=N.NAJA; TISSUE=VENOM;
RM 87184627
RA TAKECHI M., TANAKA Y., HAYASHI K.;
RL BIOCHEM. INT. 14:145-152(1987).
RN [5]
RP STRUCTURE BY NMR.
RM 93349889
RA SINGHAL A.K., CHIEN K.-Y., WU W.-G., RULE G.S.;
RL BIOCHEMISTRY 32:8036-8044(1993).
CC -!- FUNCTION: LOW CYTOTOXIN ACTIVITY. DISPLAYS POOR HEMOLYTIC ACTIVITY
CC BUT IS PROFICIENT AT INDUCING AGGREGATION AND FUSION OF
CC SPHINGOMYELIN VESICLES.
CC -!- LD(50) IS 60 MG/KG BY SUBCUTANEOUS INJECTION.
CC -!- THE TWO SEQUENCES ARE IDENTICAL.
CC -!- CAUTION: THE SEQUENCE OF POSITIONS 25-32 WAS INCORRECT IN REF.3
CC AND REF.4 DUE TO THE INVERSION OF THE ORDER OF TWO PEPTIDES.
DR PIR; S06674; S06674.
DR PIR; S09703; S09703.
DR PIR; S08259; S08259.
DR PDB; 1CVO; 31-JAN-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 40 BY SIMILARITY.
FT DISULFID 44 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7014 MW; 19456 CN;
LKCHNTQLPF IYKTCPEGKN LCFKATLKKF PLKFPVKRGC ADNCPKNSAL LKYVCCSTDK 60
CN 62
//
ID MAMB_DENJA STANDARD; PRT; 59 AA.
AC P28375;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE MAMBIN (GLYCOPROTEIN IIB-IIA ANTAGONIST) (PLATELET AGGREGATION
DE INHIBITOR).
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 92273586
RA MCDOWELL R.S., DENNIS M.S., LOUIE A., SHUSTER M., MULKERRIN M.G.,
RA LAZARUS R.A.;
RL BIOCHEMISTRY 31:4766-4772(1992).
CC -!- FUNCTION: INHIBITS ADP-INDUCED PLATELET AGGREGATION AND INHIBITS
CC THE BINDING OF PURIFIED PLATELET FIBRINOGEN RECEPTOR GPIIB-IIIA
CC TO IMMOBILIZED FIBRINOGEN.
CC -!- SIMILARITY: STRONG, TO TOXIN S5C1.
DR PIR; A42561; A42561.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW BLOOD COAGULATION; CELL ADHESION; VENOM.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 37 BY SIMILARITY.
FT DISULFID 39 51 BY SIMILARITY.
FT DISULFID 52 57 BY SIMILARITY.
FT SITE 43 45 CELL ATTACHMENT SITE (POTENTIAL).
SQ SEQUENCE 59 AA; 6754 MW; 16657 CN;
RICYNHLGTK PPTTETCQED SCYKNIWTFD NIIRRGCGCF TPRGDMPGPY CCESDKCNL 59
//
ID NXL1_ACAAN STANDARD; PRT; 73 AA.
AC P01385;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1.
OS ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 82068043
RA KIM H.S., TAMIYA N.;
RL BIOCHEM. J. 193:899-906(1981).
CC -!- LD(50) IS 0.13 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01656; N2AW1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 73 AA; 8135 MW; 28511 CN;
VICYRGYNNP QTCPPGENVC FTRTWCDAFC SSRGKVVELG CAATCPIVKS YNEVKCCSTD 60
KCNPFPVRPR RPP 73
//
ID NXL1_ASPSC STANDARD; PRT; 68 AA.
AC P25670;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN S4C6).
OS ASPIDELAPS SCUTATUS (SHIELD-NOSE SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88137796
RA JOUBERT F.J.;
RL INT. J. BIOCHEM. 20:93-96(1988).
CC -!- LD(50) IS 0.13 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 68 AA; 7457 MW; 22578 CN;
RICYIAPYDH KTCAAGENIC YLKAWCDAWC SSRGKKLEFG CAATCPTVKP GVDISCCDTD 60
NCNPHPKL 68
//
ID NXL1_ASTST STANDARD; PRT; 70 AA.
AC P01380;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN B).
OS ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79123997
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 175:507-517(1978).
CC -!- LD(50) IS 0.096 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01651; N2AT1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; AMIDATION; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
FT MOD_RES 70 70 AMIDATION.
SQ SEQUENCE 70 AA; 7574 MW; 23780 CN;
LSCYLGYKHS QTCPPGENVC FVKTWCDGFC NTRGERIIMG CAATCPTAKS GVHIACCSTD 60
NCNIYAKWGS 70
//
ID NXL1_BUNMU STANDARD; PRT; 74 AA.
AC P01378;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-JAN-1988 (REL. 06, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (ALPHA-BUNGAROTOXIN) (BGTX).
OS BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72188445
RA MEBS D., NARITA K., IWANAGA S., SAMEJIMA Y., LEE C.Y.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 353:243-262(1972).
RN [2]
RP REVISIONS TO 9-11; 67-68 AND 71-72.
RC TISSUE=VENOM;
RM 88005156
RA OHTA M., OHTA K., NISHITANI H., HAYASHI K.;
RL FEBS LETT. 222:79-82(1987).
RN [3]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88339978
RA CHUANG L.Y., CHANG C.-C.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 155:870-876(1988).
RN [4]
RP REVISIONS TO 9-11; 67-68 AND MINOR VARIANT.
RC TISSUE=VENOM;
RM 88294016
RA KOSEN P.A., FINER-MOORE J., MCCARTHY M.P., BASUS V.J.;
RL BIOCHEMISTRY 27:2775-2781(1988).
RN [5]
RP ANTIGENIC REGIONS.
RM 89378216
RA KASE R., KITAGAWA H., HAYASHI K., TANOUE K., INAGAKI F.;
RL FEBS LETT. 254:106-110(1989).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM 89184384
RA LOVE R.A., STROUD R.M.;
RL PROTEIN ENG. 1:37-46(1986).
RN [7]
RP STRUCTURE BY NMR.
RM 88294014
RA BASUS V.J., BILLETER M., LOVE R.A., STROUD R.M., KUNTZ I.D.;
RL BIOCHEMISTRY 27:2763-2771(1988).
RN [8]
RP STRUCTURE BY NMR.
RM 88294015
RA BASUS V.J., SCHEEK R.M.;
RL BIOCHEMISTRY 27:2772-2775(1988).
RN [9]
RP STRUCTURE BY NMR.
RM 94059936
RA BASUS V.J., SONG G., HAWROT E.;
RL BIOCHEMISTRY 32:12290-12298(1993).
CC -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC -!- SUBUNIT: MONOMER IN SOLUTION, HOMODIMER IN CRYSTAL STATE.
CC -!- LD(50) IS 0.3 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01649; N2KF1U.
DR PIR; S02420; S02420.
DR PIR; A31519; A31519.
DR PDB; 2ABX; 16-OCT-87.
DR PDB; 1ABT; 31-JAN-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 23
FT DISULFID 16 44
FT DISULFID 29 33
FT DISULFID 48 59
FT DISULFID 60 65
FT VARIANT 31 31 A -> V (IN MINOR VARIANT).
FT STRAND 25 26
FT STRAND 41 42
SQ SEQUENCE 74 AA; 7994 MW; 28837 CN;
IVCHTTATSP ISAVTCPPGE NLCYRKMWCD AFCSSRGKVV ELGCAATCPS KKPYEEVTCC 60
STDKCNPHPK QRPG 74
//
ID NXL1_DENJA STANDARD; PRT; 72 AA.
AC P01393;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN V-III-N1).
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74094133
RA STRYDOM A.J.C.;
RL BIOCHIM. BIOPHYS. ACTA 328:491-509(1973).
CC -!- LD(50) IS 0.38 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01664; N2EP1J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 72 AA; 8185 MW; 28115 CN;
RTCYKTYSDK SKTCPRGEDI CYTKTWCDGF CSQRGKRVEL GCAATCPKVK TGVEIKCCST 60
DYCNPFPVWN PR 72
//
ID NXL1_DENPO STANDARD; PRT; 72 AA.
AC P01396;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN GAMMA) (TOXIN VN1).
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RM 72206049
RA STRYDOM D.J.;
RL J. BIOL. CHEM. 247:4029-4042(1972).
CC -!- LD(50) IS 0.12 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01667; N2EP1D.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 72 AA; 8043 MW; 25023 CN;
RTCNKTFSDQ SKICPPGENI CYTKTWCDAW CSQRGKRVEL GCAATCPKVK AGVEIKCCST 60
DDCDKFQFGK PR 72
//
ID NXL1_DENVI STANDARD; PRT; 72 AA.
AC P01394;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXINS 4.7.3 AND 4.9.3).
OS DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74309059
RA BANKS B.E.C., MILEDI R., SHIPOLINI R.A.;
RL EUR. J. BIOCHEM. 45:457-468(1974).
CC -!- NEUROTOXIN 4.7.3 DIFFERS FROM 4.9.3 ONLY IN THAT TRP-26 HAS
CC UNDERGONE PARTIAL PHOTOOXIDATION.
CC -!- LD(50) IS 0.9 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A01665; N2EP1V.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 72 AA; 7970 MW; 25452 CN;
RTCYKTPSVK PETCPHGENI CYTETWCDAW CSQRGKREEL GCAATCPKVK AGVGIKCCST 60
DNCDPFPVKN PR 72
//
ID NXL1_LATSE STANDARD; PRT; 66 AA.
AC P01379;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (COMPONENT LSIII).
OS LATICAUDA SEMIFASCIATA (BROAD-BANDED BLUE SEA SNAKE) (ERABU SEA
OS SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75127384
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 141:389-400(1974).
CC -!- LD(50) IS 1.24 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01650; N2LT1E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 66 AA; 7260 MW; 22740 CN;
RECYLNPHDT QTCPSGQEIC YVKSWCNAWC SSRGKVLEFG CAATCPSVNT GTEIKCCSAD 60
KCNTYP 66
//
ID NXL1_NAJHC STANDARD; PRT; 72 AA.
AC P01389;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN III).
OS NAJA HAJE ANCHIETAE (ANGOLAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76043631
RA KOPEYAN C., MIRANDA F., ROCHAT H.;
RL EUR. J. BIOCHEM. 58:117-122(1975).
CC -!- LD(50) IS 0.067 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01660; N2NJ1A.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 72 AA; 7911 MW; 25602 CN;
IRCFITPDVT SQACPDGQNI CYTKTWCDNF CGMRGKRVDL GCAATCPTVK PGVDIKCCST 60
DNCNPFPTRE RS 72
//
ID NXL1_NAJHH STANDARD; PRT; 71 AA.
AC P25674;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN CM-5).
OS NAJA HAJE HAJE (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79062487
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
CC -!- LD(50) IS 0.11 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 14 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7821 MW; 25513 CN;
IRCFITPDVT SQACPDGHVC YTKMWCDNFC GMRGKRVDLG CAATCPTVKP GVDIKCCSTD 60
NCNPFPTRKR S 71
//
ID NXL1_NAJKA STANDARD; PRT; 71 AA.
AC P01391;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN 3) (ALPHA-COBRATOXIN).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA ARNBERG H., EAKER D., KARLSSON E.;
RL UNPUBLISHED RESULTS, CITED BY:
RL KARLSSON E.;
RL EXPERIENTIA 29:1319-1327(1973).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RM 80234630
RA WALKINSHAW M.D., SAENGER W., MAELICKE A.;
RL PROC. NATL. ACAD. SCI. U.S.A. 77:2400-2404(1980).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
RM 92042051
RA BETZEL C., LANGE G., PAL G.P., WILSON K.S., MAELICKE A., SAENGER W.;
RL J. BIOL. CHEM. 266:21530-21536(1991).
RN [4]
RP STRUCTURE BY NMR.
RM 91122921
RA LAPLANTE S.R., MIKOU A., ROBIN M., GUITTET E., DELSUC M.-A.,
RA CHARPENTIER I., LALLEMAND J.-Y.;
RL INT. J. PEPT. PROTEIN RES. 36:227-230(1990).
RN [5]
RP STRUCTURE BY NMR.
RM 92273600
RA LE GOAS R., LAPLANTE S.R., MIKOU A., DELSUC M.-A., GUITTET E.,
RA ROBIN M., CHARPENTIER I., LALLEMAND J.-Y.;
RL BIOCHEMISTRY 31:4867-4875(1992).
CC -!- LD(50) IS 0.1 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01662; N2NJ1S.
DR PDB; 1CTX; 30-SEP-83.
DR PDB; 2CTX; 31-JAN-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 20
FT DISULFID 14 41
FT DISULFID 26 30
FT DISULFID 45 56
FT DISULFID 57 62
FT TURN 16 17
FT STRAND 20 25
FT TURN 28 29
FT HELIX 30 33
FT STRAND 36 40
FT STRAND 53 57
FT TURN 60 61
FT TURN 68 69
SQ SEQUENCE 71 AA; 7831 MW; 25409 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDAFC SIRGKRVDLG CAATCPTVKT GVDIQCCSTD 60
NCNPFPTRKR P 71
//
ID NXL1_NAJME STANDARD; PRT; 71 AA.
AC P01383;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN 3.9.4).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74169397
RA SHIPOLINI R.A., BAILEY G.S., BANKS B.E.C.;
RL EUR. J. BIOCHEM. 42:203-211(1974).
CC -!- LD(50) IS 1.5 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A01654; N2NJ1W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 71 AA; 8056 MW; 27682 CN;
KRCYRTPDLK SQTCPPGEDL CYTKKWCADW CTSRGKVIEL GCVATCPKVK PYEQITCCST 60
DNCNPHPKMK P 71
//
ID NXL1_NAJNA STANDARD; PRT; 71 AA.
AC P25668; P01392;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (TOXIN A).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72055125
RA NAKAI K., SASAKI T., HAYASHI K.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 44:893-897(1971).
CC -!- LD(50) IS 0.15 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01663; N2NJ1I.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20
FT DISULFID 14 41
FT DISULFID 26 30
FT DISULFID 45 56
FT DISULFID 57 62
SQ SEQUENCE 71 AA; 7847 MW; 25239 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SIRGKRVDLG CAATCPTVRT GVDIQCCSTD 60
DCDPFPTRKR P 71
//
ID NXL1_NAJNI STANDARD; PRT; 71 AA.
AC P01390;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72068724
RA BOTES D.P.;
RL J. BIOL. CHEM. 246:7383-7391(1971).
CC -!- LD(50) IS 0.076 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01661; N2NJ1C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20
FT DISULFID 14 41
FT DISULFID 26 30
FT DISULFID 45 56
FT DISULFID 57 62
SQ SEQUENCE 71 AA; 7902 MW; 24340 CN;
IRCFITPDVT SQACPDGHVC YTKMWCDNFC GMRGKRVDLG CAATCPKVKP GVNIKCCSRD 60
NCNPFPTRKR S 71
//
ID NXL1_NAJOX STANDARD; PRT; 73 AA.
AC P01382;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN I).
OS NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75006884
RA GRISHIN E.V., SUKHIKH A.P., SLOBODYAN L.N., OVCHINNIKOV Y.A.,
RA SOROKIN V.M.;
RL FEBS LETT. 45:118-121(1974).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RM 90353587
RA MIKHAILOV A.M., NICKITENCKO A.V., TRAKHANOV S.D., VAINSHTEIN B.K.,
RA CHETVERINA E.V.;
RL FEBS LETT. 269:255-257(1990).
CC -!- LD(50) IS 0.56 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A01653; N2NJ1R.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 43 BY SIMILARITY.
FT DISULFID 28 32 BY SIMILARITY.
FT DISULFID 47 58 BY SIMILARITY.
FT DISULFID 59 64 BY SIMILARITY.
SQ SEQUENCE 73 AA; 8031 MW; 26741 CN;
ITCYKTPIPI TSETCAPGQN LCYTKTWCDA WCGSRGKVIE LGCAATCPTV ESYQDIKCCS 60
TDDCNPHPKQ KRP 73
//
ID NXL1_NOTSC STANDARD; PRT; 73 AA.
AC P01384;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NOTECHIS III-4).
OS NOTECHIS SCUTATUS SCUTATUS (MAINLAND TIGER SNAKE) (COMMON TIGER
OS SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80043177
RA HALPERT J., FOHLMAN J., EAKER D.;
RL BIOCHIMIE 61:719-723(1979).
CC -!- LD(50) IS 0.125 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01655; N2NO1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 73 AA; 8060 MW; 27995 CN;
LICYMGPKTP RTCPRGQNLC YTKTWCDAFC SSRGKVVELG CAATCPIAKS YEDVTCCSTD 60
NCNPFPVRPR HPP 73
//
ID NXL1_OPHHA STANDARD; PRT; 73 AA.
AC P01387;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 1 (NEUROTOXIN A).
OS OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 73231298
RA JOUBERT F.J.;
RL BIOCHIM. BIOPHYS. ACTA 317:85-98(1973).
CC -!- LD(50) IS 0.3 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01658; N2OH1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 73 AA; 8106 MW; 27546 CN;
TKCYVTPDVK SETCPAGQDI CYTETWCDAW CTSRGKRVDL GCAATCPIVK PGVEIKCCST 60
DNCNPFPTWR KRP 73
//
ID NXL2_ASTST STANDARD; PRT; 72 AA.
AC P01381;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (TOXIN C).
OS ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79123997
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 175:507-517(1978).
CC -!- LD(50) IS 0.096 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01652; N2AT2.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; AMIDATION; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 13 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
FT MOD_RES 72 72 AMIDATION.
SQ SEQUENCE 72 AA; 7790 MW; 26135 CN;
LSCYLGYKHS QTCPPGENVC FVKTWCDAFC STRGERIVMG CAATCPTAKS GVHIACCSTD 60
NCNIYTKWGS GR 72
//
ID NXL2_BUNFL STANDARD; PRT; 66 AA.
AC P15815;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (KAPPA-FLAVITOXIN).
OS BUNGARUS FLAVICEPS FLAVICEPS (RED-HEADED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88309785
RA GRANT G.A., FRAZIER M.W., CHIAPPINELLI V.A.;
RL BIOCHEMISTRY 27:3794-3798(1988).
CC -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR PIR; A28644; A28644.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 58 BY SIMILARITY.
FT DISULFID 59 64 BY SIMILARITY.
SQ SEQUENCE 66 AA; 7259 MW; 21389 CN;
RTCLISPSST SQTCPKGQDI CFTKAFCDRW CSSRGPVIEQ GCAATCPEFT SRYKSLLCCT 60
TDNCNH 66
//
ID NXL2_BUNMU STANDARD; PRT; 66 AA.
AC P01398;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (KAPPA-BUNGAROTOXIN) (NEURONAL-BUNGAROTOXIN) (TOXIN
DE F).
OS BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 85175111
RA GRANT G.A., CHIAPPINELLI V.A.;
RL BIOCHEMISTRY 24:1532-1537(1985).
RN [2]
RP STRUCTURE BY NMR.
RM 91242387
RA OSWALD R.E., SUTCLIFFE M.J., BAMBERGER M., LORING R.H., BRASWELL E.,
RA DOBSON C.M.;
RL BIOCHEMISTRY 30:4901-4909(1991).
RN [3]
RP STRUCTURE BY NMR.
RM 92198912
RA SUTCLIFFE M.J., DOBSON C.M., OSWALD R.E.;
RL BIOCHEMISTRY 31:2962-2970(1992).
CC -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
CC -!- SUBUNIT: HOMODIMER.
DR PIR; A01669; N1KF2U.
DR PDB; 1NBT; 31-OCT-93.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; 3D-STRUCTURE.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 58 BY SIMILARITY.
FT DISULFID 59 64 BY SIMILARITY.
SQ SEQUENCE 66 AA; 7275 MW; 20391 CN;
RTCLISPSST PQTCPNGQDI CFLKAQCDKF CSIRGPVIEQ GCVATCPQFR SNYRSLLCCT 60
TDNCNH 66
//
ID NXL2_DENPO STANDARD; PRT; 72 AA.
AC P01397;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (NEUROTOXIN DELTA) (TOXIN TN2).
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RA STRYDOM D.J.;
RL THESIS (1973), UNIVERSITY OF PRETORIA, SOUTH-AFRICA.
DR PIR; A01668; N2EP2D.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
FT CONFLICT 7 7 P -> F (IN PIR DATA BANK).
SQ SEQUENCE 72 AA; 7948 MW; 25602 CN;
RTCNKTPSDQ SKICPPGENI CYTKTWCDAW CSQRGKIVEL GCAATCPKVK AGVEIKCCST 60
DNCNKFKFGK PR 72
//
ID NXL2_DENVI STANDARD; PRT; 73 AA.
AC P01395;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (TOXINS I AND V).
OS DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77025828
RA BECHIS G., GRANIER C., VAN RIETSCHOTEN J., JOVER E., ROCHAT H.,
RA MIRANDA F.;
RL EUR. J. BIOCHEM. 68:445-456(1976).
CC -!- THE VARIANT I SEQUENCE IS SHOWN.
CC -!- LD(50) IS 0.045 MG/KG BY SUBCUTANEOUS INJECTION FOR VARIANT I, AND
CC 0.08 MG/KG FOR VARIANT V.
DR PIR; A01666; N2EP2V.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
FT VARIANT 73 73 MISSING (IN VARIANT V).
SQ SEQUENCE 73 AA; 8054 MW; 26880 CN;
RTCYKTPSVK PETCPHGENI CYTETWCDAW CSQRGKRVEL GCAATCPKVK AGVGIKCCST 60
DNCNPFPVWN PRG 73
//
ID NXL2_NAJME STANDARD; PRT; 71 AA.
AC P01388;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (NEUROTOXIN B).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RM 72181379
RA BOTES D.P.;
RL J. BIOL. CHEM. 247:2866-2871(1972).
DR PIR; A01659; N2NJ2W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 14 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7772 MW; 24650 CN;
IRCFITPDVT SQICADGHVC YTKTWCDNFC ASRGKRVDLG CAATCPTVKP GVNIKCCSTD 60
NCNPFPTRNR P 71
//
ID NXL2_NAJNA STANDARD; PRT; 71 AA.
AC P25669; P01392;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (TOXIN B).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA OHTA M., SASAKI T., HAYASHI K.;
RL FEBS LETT. 71:161-166(1976).
DR PIR; A01663; N2NJ1I.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20
FT DISULFID 14 41
FT DISULFID 26 30
FT DISULFID 45 56
FT DISULFID 57 62
SQ SEQUENCE 71 AA; 7821 MW; 25431 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SSRGKRVDLG CAATCPTVRT GVDIQCCSTD 60
DCDPFPTRKR P 71
//
ID NXL2_OPHHA STANDARD; PRT; 73 AA.
AC P01386;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 2 (NEUROTOXIN B).
OS OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 73231298
RA JOUBERT F.J.;
RL BIOCHIM. BIOPHYS. ACTA 317:85-98(1973).
CC -!- LD(50) IS 0.35 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01657; N2OH2.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 73 AA; 8053 MW; 27458 CN;
TKCYVTPDAT SQTCPDGQDI CYTKTWCDGF CSSRGKRIDL GCAATCPKVK PGVDIKCCST 60
DNCNPFPTWK RKH 73
//
ID NXL3_BUNMU STANDARD; PRT; 87 AA.
AC P15816;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN CB1 PRECURSOR (KAPPA NEUROTOXIN).
OS BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90192091
RA DANSE J.M., GARNIER J.M.;
RL NUCLEIC ACIDS RES. 18:1050-1050(1990).
CC -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR EMBL; X51412; BMKNCB1.
DR PIR; S08399; S08399.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 87 LONG NEUROTOXIN CB1.
FT DISULFID 24 42 BY SIMILARITY.
FT DISULFID 35 63 BY SIMILARITY.
FT DISULFID 48 52 BY SIMILARITY.
FT DISULFID 67 79 BY SIMILARITY.
FT DISULFID 80 85 BY SIMILARITY.
SQ SEQUENCE 87 AA; 9517 MW; 36118 CN;
MKTLLLTLVV VTIVCLDLGY TKTCLKTPSS TPQTCPQGQD ICFLKVSCEQ FCPIRGPVIE 60
QGCAATCPEF RSNDRSLLCC TTDNCNH 87
//
ID NXL3_DENPO STANDARD; PRT; 72 AA.
AC P25667;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 3 (TOXIN VN2).
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RA STRYDOM D.J., HAYLETT T.;
RL S. AFR. J. CHEM. 30:40-48(1977).
CC -!- LD(50) IS 0.4 MG/KG BY SUBCUTANEOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 72 AA; 7939 MW; 25452 CN;
RTCNKTFSDQ SKICPPGENI CYTKTWCDAW CSRRGKIVEL GCAATCPKVK AGVGIKCCST 60
DNCNLFKFGK PR 72
//
ID NXL3_NAJNA STANDARD; PRT; 71 AA.
AC P25671;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 3 (TOXIN C).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA OHTA M., SASAKI T., HAYASHI K.;
RL CHEM. PHARM. BULL. 29:1458-1462(1981).
CC -!- LD(50) IS 0.10 TO 0.15 MG/KG BY SUBCUTANEOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 14 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7833 MW; 25533 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDAFC SIRGKRVDLG CAATCPTVKT GVDIQCCSTD 60
DCDPFPTRKR P 71
//
ID NXL3_OPHHA STANDARD; PRT; 73 AA.
AC P07526;
DT 01-APR-1988 (REL. 07, CREATED)
DT 01-APR-1988 (REL. 07, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 3 (NEUROTOXIN CM-9).
OS OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA LIN N.Q., ZHANG Y.S., MU J.F., WANG W.Y., YANG C.J., XIONG Y.L.;
RL ACTA BIOCHIM. BIOPHYS. SIN. 16:592-596(1984).
DR PIR; JC0005; N2OH3.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21
FT DISULFID 14 42
FT DISULFID 27 31
FT DISULFID 46 57
FT DISULFID 58 63
SQ SEQUENCE 73 AA; 7957 MW; 30326 CN;
TKCYVTPDVK SETCPAGQDL CYTETWCVAW CTVRGKRVSL TCAAICPIVP PKVSIKCCST 60
DACGPFPTWP NVR 73
//
ID NXL4_BUNMU STANDARD; PRT; 87 AA.
AC P15817;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN CR1 PRECURSOR (KAPPA NEUROTOXIN).
OS BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90192091
RA DANSE J.M., GARNIER J.M.;
RL NUCLEIC ACIDS RES. 18:1050-1050(1990).
CC -!- FUNCTION: NEUROTOXIN, BINDS AND INHIBITS NICOTINIC RECEPTORS.
CC COMPARED TO ALPHA-NEUROTOXINS, KAPPA-NEUROTOXIN BIND MORE STRONGLY
CC TO NEURONAL RECEPTORS, AND LESS STRONGLY TO MUSCLE RECEPTORS.
DR EMBL; X51413; BMKNCR1.
DR PIR; S08398; S08398.
DR PIR; B60549; B60549.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 87 LONG NEUROTOXIN CR1.
FT DISULFID 24 42 BY SIMILARITY.
FT DISULFID 35 63 BY SIMILARITY.
FT DISULFID 48 52 BY SIMILARITY.
FT DISULFID 67 79 BY SIMILARITY.
FT DISULFID 80 85 BY SIMILARITY.
SQ SEQUENCE 87 AA; 9660 MW; 34712 CN;
MKTLLLSLVV VTIVCLDLGY TRTCLISPSS TPQTCPNGQD ICFRKAQCDN FCHSRGPVIE 60
QGCVATCPQF RSNYRSLLCC RTDNCNH 87
//
ID NXL4_NAJNA STANDARD; PRT; 71 AA.
AC P25672;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 4 (TOXIN D).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 82113654
RA OHTA M., SASAKI T., HAYASHI K.;
RL BIOCHIM. BIOPHYS. ACTA 671:123-128(1981).
CC -!- LD(50) IS 0.22 MG/KG BY SUBCUTANEOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 14 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7889 MW; 25120 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDGFC RIRGERVDLG CAATCPTVKT GVDIQCCSTD 60
DCDPFPTRKR P 71
//
ID NXL4_OPHHA STANDARD; PRT; 72 AA.
AC P80156;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 4 (ALPHA-NEUROTOXIN).
OS OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 93191697
RA CHANG C.-C., HUANG T.-Y., KUO K.-W., CHEN S.W., HUANG K.F.,
RA CHIOU S.-H.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 191:214-223(1993).
DR PIR; JC1474; JC1474.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 15 43 BY SIMILARITY.
FT DISULFID 28 32 BY SIMILARITY.
FT DISULFID 47 58 BY SIMILARITY.
FT DISULFID 59 64 BY SIMILARITY.
SQ SEQUENCE 72 AA; 8014 MW; 26927 CN;
TKCYKTGDRI ISEACPPGQD LCYMKTWCDV FCGTRGRVIE LGCTATCPTV KPHEQITCCS 60
TDNCNPHPKM KQ 72
//
ID NXL5_NAJNA STANDARD; PRT; 71 AA.
AC P25673;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN 5 (TOXIN E).
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 88125327
RA HAYASHI K.;
RL UNPUBLISHED RESULTS, CITED BY:
RL ENDO T., TAMIYA N.;
RL PHARMACOL. THER. 34:403-451(1987).
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 20 BY SIMILARITY.
FT DISULFID 14 41 BY SIMILARITY.
FT DISULFID 26 30 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7863 MW; 25298 CN;
IRCFITPDIT SKDCPNGHVC YTKTWCDGFC SRRGERVDLG CAATCPTVKT GVDIQCCSTD 60
DCDPFPTRKR P 71
//
ID NXLB_PSETE STANDARD; PRT; 71 AA.
AC P13495;
DT 01-JAN-1990 (REL. 13, CREATED)
DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN B (PSEUDONAJATOXIN B).
OS PSEUDONAJA TEXTILIS (EASTERN BROWN SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 87246668
RA TYLER M.I., SPENCE I., BARNETT D., HOWDEN M.E.H.;
RL EUR. J. BIOCHEM. 166:139-143(1987).
CC -!- FUNCTION: LETHAL NEUROTOXIN.
CC -!- LD(50) IS 0.015 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; S00035; S00035.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 58 BY SIMILARITY.
FT DISULFID 59 64 BY SIMILARITY.
SQ SEQUENCE 71 AA; 7761 MW; 25164 CN;
RTCFITPDVK SKPCPPGQEV CYTETWCDGF CGIRGKRVEL GCAATCPTPK KTGIDIQCCS 60
TDDCNTFPLR P 71
//
ID NXLD_ACAAN STANDARD; PRT; 74 AA.
AC P34073;
DT 01-FEB-1994 (REL. 28, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE ACANTHOPHIN D (POSTSYNAPTIC NEUROTOXIN).
OS ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA SHEUMACK D.D., SPENCE I., TYLER M.I., HOWDEN M.E.H.;
RL COMP. BIOCHEM. PHYSIOL. 95B:45-50(1990).
DR PIR; A60518; A60518.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 74 AA; 8387 MW; 26908 CN;
VICYRKYTNN VKTCPDGENV CYTKMWCDGF CTSRGKVVEL GCAATCPIRK PGNEVKCCST 60
NKCNHPPKRK KRRP 74
//
ID NXLH_BUNMU STANDARD; PRT; 87 AA.
AC P15818;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN HOMOLOG PRECURSOR.
OS BUNGARUS MULTICINCTUS (MANY-BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90192086
RA DANSE J.M., GARNIER J.M., KEMPF J.;
RL NUCLEIC ACIDS RES. 18:1045-1045(1990).
DR EMBL; X51414; BMNHMR.
DR PIR; S08401; S08401.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 87 LONG NEUROTOXIN HOMOLOG.
SQ SEQUENCE 87 AA; 9658 MW; 37335 CN;
MKTLLLTLVV VTIVCLDLGY TMKCKICHFD TCRAGELKVC ASGEKYCFKE SWREARGTRI 60
ERGCAATCPK GSVYGLYVLC CTTDDCN 87
//
ID NXLH_PSEAU STANDARD; PRT; 68 AA.
AC P14612;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-APR-1993 (REL. 25, LAST ANNOTATION UPDATE)
DE LONG NEUROTOXIN HOMOLOG PA ID.
OS PSEUDECHIS AUSTRALIS (MULGA SNAKE) (KING BROWN SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 89380113
RA TAKASAKI C.;
RL J. BIOCHEM. 106:11-16(1989).
CC -!- FUNCTION: THIS PROTEIN IS NOT TOXIC.
DR PIR; JU0034; JU0034.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 42 BY SIMILARITY.
FT DISULFID 27 31 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 68 AA; 7761 MW; 22835 CN;
LTCYKGRDRS SETCRSEQEL CCTKTWCDQW CQDRGPRLEM GCTATCPRRM PGLDFTCCTT 60
DNCNPVPT 68
//
ID NXS1_ACAAN STANDARD; PRT; 62 AA.
AC P01434;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN AA C).
OS ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 82160151
RA KIM H.S., TAMIYA N.;
RL BIOCHEM. J. 199:211-218(1981).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.08 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01702; N1AW1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6880 MW; 17921 CN;
MQCCNQQSSQ PKTTTTCPGG VSSCYKKTWR DHRGTIIERG CGCPRVKPGI RLICCKTDEC 60
NN 62
//
ID NXS1_AIPLA STANDARD; PRT; 60 AA.
AC P32879; P01439;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN A.
OS AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76160626
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 153:79-87(1976).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01707; N1AY1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6726 MW; 16102 CN;
LTCCNQQSSQ PKTTTDCADN SCYKKTWQDH RGTRIERGCG CPQVKPGIKL ECCKTNECNN 60
//
ID NXS1_ASTST STANDARD; PRT; 60 AA.
AC P01438; P10461; P19005;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN A).
OS ASTROTIA STOKESI (STOKES'S SEA SNAKE) (DISTEIRA STOKESI), HYDROPHIS
OS ORNATUS (REEF SEA SNAKE), AND ACALYPTOPHIS PERONII (SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC SPECIES=A.STOKESI; TISSUE=VENOM;
RM 79123997
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 175:507-517(1978).
RN [2]
RP COMPOSITIONS OF TRYPTIC PEPTIDES.
RC SPECIES=H.ORNATUS; TISSUE=VENOM;
RM 83308533
RA TAMIYA N., MAEDA N., COGGER H.G.;
RL BIOCHEM. J. 213:31-38(1983).
RN [3]
RP MAJOR VARIANT, SEQUENCE.
RC SPECIES=A.PERONII; TISSUE=VENOM;
RM 88132805
RA MORI N., TU A.T.;
RL ARCH. BIOCHEM. BIOPHYS. 260:10-17(1988).
RN [4]
RP MINOR VARIANT, SEQUENCE.
RC SPECIES=A.PERONII; TISSUE=VENOM;
RM 89076487
RA MORI N., TU A.T.;
RL BIOL. CHEM. HOPPE-SEYLER 369:521-526(1988).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.170 MG/KG BY INTRAVENOUS INJECTION FOR A.PERONII MINOR
CC TOXIN, 0.125 MG/KG FOR THE MAJOR TOXIN.
CC -!- LD(50) IS 0.13 MG/KG BY INTRAMUSCULAR INJECTION FOR A.STOKESI.
DR PIR; A01706; N1AT1.
DR PIR; A90321; N1AT1F.
DR PIR; A27580; A27580.
DR PIR; S02484; S02484.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
FT VARIANT 43 43 Q -> E (IN A.PERONII MINOR VARIANT).
SQ SEQUENCE 60 AA; 6599 MW; 16600 CN;
MTCCNQQSSQ PKTTTNCAGN SCYKKTWSDH RGTIIERGCG CPQVKSGIKL ECCHTNECNN 60
//
ID NXS1_BOUAN STANDARD; PRT; 61 AA.
AC P34075;
DT 01-FEB-1994 (REL. 28, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1.
OS BOULENGERINA ANNULATA ANNULATA (BANDED WATER COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 92263369
RA WEINSTEIN S.A., SCHMIDT J.J., SMITH L.A.;
RL TOXICON 29:1315-1327(1991).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.052 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A39327; A39327.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6837 MW; 18691 CN;
KICYNQPSSQ HPTTKACPGE KNCYRKQWSD HRGTIIERGC GCPTVKPGVK LHCCTTEKCN 60
N 61
//
ID NXS1_BOUCH STANDARD; PRT; 62 AA.
AC P34076;
DT 01-FEB-1994 (REL. 28, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1.
OS BOULENGERINA CHRISTYI (CHRISTY'S WATER COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 92263369
RA WEINSTEIN S.A., SCHMIDT J.J., SMITH L.A.;
RL TOXICON 29:1315-1327(1991).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.083 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; B39327; B39327.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6894 MW; 18864 CN;
MECHNQQSSQ PPTTTHCSGG ETNCYEKRWH DHRGTIIERG CGCPTVKPGV KLNCCTTDKC 60
NN 62
//
ID NXS1_BUNFA STANDARD; PRT; 64 AA.
AC P10808;
DT 01-JUL-1989 (REL. 11, CREATED)
DT 01-JUL-1989 (REL. 11, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN V-II-1).
OS BUNGARUS FASCIATUS (BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 89291813
RA LIU C.-S., CHEN J.-P., CHANG C.-S., LO T.-B.;
RL J. BIOCHEM. 105:93-97(1989).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; JX0060; JX0060.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 26 BY SIMILARITY.
FT DISULFID 20 43 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 64 AA; 7272 MW; 18570 CN;
RICLNQQQST PEDQPTNGQC YIKTDCQNKT WNTHRGSRTD RGCGCPKVKP GINLRCCKTD 60
KCNE 64
//
ID NXS1_DENJA STANDARD; PRT; 60 AA.
AC P01417;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74094133
RA STRYDOM A.J.C.;
RL BIOCHIM. BIOPHYS. ACTA 328:491-509(1973).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.11 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01687; N1EP1J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6729 MW; 16753 CN;
RICYNHQSTT PATTKSCGEN SCYKKTWSDH RGTIIERGCG CPKVKQGIHL HCCQSDKCNN 60
//
ID NXS1_DENPO STANDARD; PRT; 60 AA.
AC P01416;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72206049
RA STRYDOM D.J.;
RL J. BIOL. CHEM. 247:4029-4042(1972).
RN [2]
RP STRUCTURE BY NMR.
RM 89052698
RA LABHARDT A.L., HUNZIKER-KWIK E.H., WUETHRICH K.;
RL EUR. J. BIOCHEM. 177:295-305(1988).
RN [3]
RP STRUCTURE BY NMR.
RM 93059364
RA BROWN L.R., WUETHRICH K.;
RL J. MOL. BIOL. 227:1118-1135(1992).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01686; N1EP1D.
DR PIR; S01797; S01797.
DR PDB; 1NTX; 31-JAN-94.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW 3D-STRUCTURE.
FT DISULFID 3 22
FT DISULFID 17 39
FT DISULFID 41 52
FT DISULFID 53 58
SQ SEQUENCE 60 AA; 6915 MW; 18007 CN;
RICYNHQSTT RATTKSCEEN SCYKKYWRDH RGTIIERGCG CPKVKPGVGI HCCQSDKCNY 60
//
ID NXS1_DENVI STANDARD; PRT; 60 AA.
AC P01418;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN 4.11.3).
OS DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74309059
RA BANKS B.E.C., MILEDI R., SHIPOLINI R.A.;
RL EUR. J. BIOCHEM. 45:457-468(1974).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.08 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A91220; N1EP1V.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6743 MW; 17049 CN;
RICYNHQSTT PATTKSCGEN SCYKKTWSDH RGTIIERGCG CPKVKRGVHL HCCQSDKCNN 60
//
ID NXS1_ENHSC STANDARD; PRT; 60 AA.
AC P25492; P01436;
DT 01-JUL-1986 (REL. 01, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN 4).
OS ENHYDRINA SCHISTOSA (BEAKED SEA SNAKE) (COMMON SEA SNAKE), AND
OS LAPEMIS HARDWICKII (HARDWICK'S SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP TOXIN 4, SEQUENCE.
RC SPECIES=E.SCHISTOSA; TISSUE=VENOM;
RM 73127342
RA FRYKLUND L., EAKER D., KARLSSON E.;
RL BIOCHEMISTRY 11:4633-4640(1972).
RN [2]
RP SEQUENCE.
RC SPECIES=L.HARDWICKII; TISSUE=VENOM;
RM 77246775
RA FOX J.W., ELZINGA M., TU A.T.;
RL FEBS LETT. 80:217-220(1977).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.2 MG/KG BY INTRAVENOUS INJECTION FOR E.SCHISTOSA.
DR PIR; A01705; N1EY1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6697 MW; 16523 CN;
MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKPGIKL ECCHTNECNN 60
//
ID NXS1_HEMHA STANDARD; PRT; 61 AA.
AC P01425;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN II).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 71116407
RA STRYDOM A.J.C., BOTES D.P.;
RL J. BIOL. CHEM. 246:1341-1349(1971).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.11 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01694; N1RI1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6838 MW; 16908 CN;
LECHNQQSSQ PPTTKSCPGD TNCYNKRWRD HRGTIIERGC GCPTVKPGIN LKCCTTDRCN 60
N 61
//
ID NXS1_HYDCY STANDARD; PRT; 60 AA.
AC P25494;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (HYDROPHITOXIN A).
OS HYDROPHIS CYANOCINCTUS (ASIAN ANNULATED SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75160244
RA LUI C.-S., BLACKWELL R.Q.;
RL TOXICON 12:543-546(1974).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6729 MW; 16385 CN;
MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKKGIKL ECCHTNECNN 60
//
ID NXS1_HYDLA STANDARD; PRT; 60 AA.
AC P01437;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN A).
OS HYDROPHIS LAPEMOIDES (PERSIAN GULF SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 83308533
RA TAMIYA N., MAEDA N., COGGER H.G.;
RL BIOCHEM. J. 213:31-38(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.09 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A90321; N1EY1H.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6777 MW; 16281 CN;
MTCCNQQSSQ PKTTTNCAES SCYKKTWRDF RGTRIERGCG CPQVKPGIKL ECCHTNECNN 60
//
ID NXS1_LATSE STANDARD; PRT; 83 AA.
AC P01435;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-OCT-1993 (REL. 27, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 PRECURSOR (ERABUTOXIN A, B, AND C).
OS LATICAUDA SEMIFASCIATA (BROAD-BANDED BLUE SEA SNAKE) (ERABU SEA
OS SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP ERABUTOXIN A, SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 85226575
RA TAMIYA T., LAMOUROUX A., JULIEN J.-F., GRIMA B., MALLET J.,
RA FROMAGEOT P., MENEZ A.;
RL BIOCHIMIE 67:185-189(1985).
RN [2]
RP ERABUTOXIN B, SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90098883
RA OBARA K., FUSE N., TSUCHIYA T., NONOMURA Y., MENEZ A., TAMIYA T.;
RL NUCLEIC ACIDS RES. 17:10490-10490(1989).
RN [3]
RP ERABUTOXIN C, SEQUENCE FROM N.A.
RC TISSUE=LIVER;
RM 91065366
RA FUSE N., TSUCHIYA T., NONOMURA Y., MENEZ A., TAMIYA T.;
RL EUR. J. BIOCHEM. 193:629-633(1990).
RN [4]
RP ERABUTOXIN A AND B, SEQUENCE.
RM 72052052
RA SATO S., TAMIYA N.;
RL BIOCHEM. J. 122:453-461(1971).
RN [5]
RP ERABUTOXIN C, PARTIAL SEQUENCE.
RM 73220193
RA TAMIYA N., ABE H.;
RL BIOCHEM. J. 130:547-555(1972).
RN [6]
RP DISULFIDE BONDS.
RM 72052053
RA ENDO Y., SATO S., ISHII S., TAMIYA N.;
RL BIOCHEM. J. 122:463-467(1971).
RN [7]
RP A, B, AND C VARIANTS, REVISIONS.
RM 78060308
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 167:289-291(1977).
RN [8]
RP ERABUTOXIN B, PRELIMINARY SEQUENCE.
RM 77158096
RA TSERNOGLOU D., PETSKO G.A., TU A.T.;
RL BIOCHIM. BIOPHYS. ACTA 491:605-608(1977).
RN [9]
RP ERABUTOXIN A, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM 77149032
RA TSERNOGLOU D., PETSKO G.A.;
RL PROC. NATL. ACAD. SCI. U.S.A. 74:971-974(1977).
RN [10]
RP ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RM 77003690
RA TSERNOGLOU D., PETSKO G.A.;
RL FEBS LETT. 68:1-4(1976).
RN [11]
RP ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RM 79231589
RA KIMBALL M.R., SATO A., RICHARDSON J.S., ROSEN L.S., LOW B.W.;
RL BIOCHEM. BIOPHYS. RES. COMMUN. 88:950-959(1979).
RN [12]
RP ERABUTOXIN B, X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
RM 93039914
RA SALUDJIAN P., PRANGE T., NAVAZA J., MENEZ R., GUILLOTEAU J.P.,
RA RIES-KAUTT M., DUCRUIX A.;
RL ACTA CRYSTALLOGR. B 48:520-531(1992).
RN [13]
RP ERABUTOXIN A, X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
RM 89255415
RA CORFIELD P.W.R., LEE T.-J., LOW B.W.;
RL J. BIOL. CHEM. 264:9239-9242(1989).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.15 MG/KG BY INTRAMUSCULAR INJECTION.
DR EMBL; X02533; LSERAAR.
DR EMBL; X16950; LSERABUB.
DR EMBL; X51410; LSERABUTO.
DR PIR; A01703; N1LT2E.
DR PIR; A01704; N1LT1E.
DR PIR; S06931; S06931.
DR PIR; S14003; S14003.
DR PDB; 1NXB; 22-OCT-84.
DR PDB; 3EBX; 09-OCT-88.
DR PDB; 5EBX; 15-APR-90.
DR PDB; 6EBX; 15-JAN-93.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL;
KW 3D-STRUCTURE.
FT SIGNAL 1 21
FT CHAIN 22 83 SHORT NEUROTOXIN 1.
FT DISULFID 24 45
FT DISULFID 38 62
FT DISULFID 64 75
FT DISULFID 76 81
FT VARIANT 47 47 N -> H (IN VARIANTS B & C).
FT VARIANT 72 72 K -> N (IN VARIANT C).
FT VARIANT 80 80 V -> R (IN REF. 8: B VARIANT, MAYBE A
FT REAL DIFFERENCE BETWEEN THE PHILIPPINE &
FT JAPANESE POPULATIONS.
FT STRAND 23 25
FT TURN 29 30
FT STRAND 35 37
FT TURN 40 41
FT STRAND 45 51
FT STRAND 56 62
FT TURN 69 70
FT STRAND 72 76
FT TURN 79 80
SQ SEQUENCE 83 AA; 9137 MW; 36368 CN;
MKTLLLTLVV VTIVCLDLGY TRICFNHQSS QPQTTKTCSP GESSCYNKQW SDFRGTIIER 60
GCGCPTVKPG IKLSCCESEV CNN 83
//
ID NXS1_NAJAT STANDARD; PRT; 62 AA.
AC P01430;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (COBROTOXIN).
OS NAJA ATRA (CHINESE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 69294410
RA YANG C.C., YANG H.J., HUANG J.S.;
RL BIOCHIM. BIOPHYS. ACTA 188:65-77(1969).
RN [2]
RP DISULFIDE BONDS.
RM 71125117
RA YANG C.C., YANG H.J., CHIU R.H.C.;
RL BIOCHIM. BIOPHYS. ACTA 214:355-363(1970).
RN [3]
RP STRUCTURE BY NMR.
RM 91065386
RA YU C., LEE C.-S., CHUANG L.-C., SHEI Y.-R., WANG C.Y.;
RL EUR. J. BIOCHEM. 193:789-799(1990).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.09 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01698; N1NJ1F.
DR PIR; D40667; D40667.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24
FT DISULFID 17 41
FT DISULFID 43 54
FT DISULFID 55 60
SQ SEQUENCE 62 AA; 6957 MW; 16811 CN;
LECHNQQSSQ TPTTTGCSGG ETNCYKKRWR DHRGYRTERG CGCPSVKNGI EINCCTTDRC 60
NN 62
//
ID NXS1_NAJHA STANDARD; PRT; 61 AA.
AC P01429;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA) (TOXIN CM-6) (NEUROTOXIN DELTA).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA), NAJA HAJE HAJE (EGYPTIAN
OS COBRA), AND NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP ALPHA, SEQUENCE.
RC SPECIES=N.H.ANNULIFERA; TISSUE=VENOM;
RM 69257191
RA BOTES D.P., STRYDOM D.J.;
RL J. BIOL. CHEM. 244:4147-4157(1969).
RN [2]
RP SEQUENCE.
RC SPECIES=N.N.HAJE; TISSUE=VENOM;
RM 79062487
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
RN [3]
RP DELTA, SEQUENCE.
RC SPECIES=N.NIVEA; TISSUE=VENOM;
RM 71185682
RA BOTES D.P., STRYDOM D.J., ANDERSON C.G., CHRISTENSEN P.A.;
RL J. BIOL. CHEM. 246:3132-3139(1971).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.105 MG/KG BY SUBCUTANEOUS INJECTION FOR ALPHA, 0.10
CC MG/KG BY INTRAVENOUS INJECTION FOR CM-6, AND 0.086 MG/KG BY
CC INTRAVENOUS INJECTION FOR DELTA.
CC -!- THE SEQUENCE OF THESE THREE TOXINS ARE IDENTICAL.
DR PIR; A01697; N1NJ1E.
DR PIR; A92084; N1NJ2C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6844 MW; 17503 CN;
LECHNQQSSQ PPTTKTCPGE TNCYKKRWRD HRGSITERGC GCPSVKKGIE INCCTTDKCN 60
N 61
//
ID NXS1_NAJKA STANDARD; PRT; 62 AA.
AC P14613;
DT 01-APR-1990 (REL. 14, CREATED)
DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (TOXIN C-6).
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 90035789
RA CHIOU S.-H., LIN W.-W., CHANG W.-P.;
RL INT. J. PEPT. PROTEIN RES. 34:148-152(1989).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; JK0221; JK0221.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6983 MW; 16757 CN;
LECHNQQSIQ TPTTTGCSGG ETNCYKKRWR DHRGYRTERG CGCPSVKNGI EINCCTTDRC 60
NN 62
//
ID NXS1_NAJME STANDARD; PRT; 61 AA.
AC P01424;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN D).
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72181379
RA BOTES D.P.;
RL J. BIOL. CHEM. 247:2866-2871(1972).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; A01693; N1NJ1W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6804 MW; 17961 CN;
MECHNQQSSQ PPTTKTCPGE TNCYKKQWSD HRGTIIERGC GCPSVKKGVK INCCTTDRCN 60
N 61
//
ID NXS1_NAJMO STANDARD; PRT; 62 AA.
AC P01431;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN I).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 78043196
RA GREGOIRE J., ROCHAT H.;
RL EUR. J. BIOCHEM. 80:283-293(1977).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.04 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01699; N1NJ1M.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7081 MW; 17232 CN;
LECHNQQSSE PPTTTRCSGG ETNCYKKRWR DHRGYRTERG CGCPTVKKGI ELNCCTTDRC 60
NN 62
//
ID NXS1_NAJOX STANDARD; PRT; 61 AA.
AC P01427;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA) (NEUROTOXIN II).
OS NAJA OXIANA (CENTRAL ASIAN COBRA) (OXUS COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 74298095
RA ARNBERG H., EAKER D., FRYKLUND L., KARLSSON E.;
RL BIOCHIM. BIOPHYS. ACTA 359:222-232(1974).
RN [2]
RP PRELIMINARY SEQUENCE.
RM 74015986
RA GRISHIN E.V., SUKHIKH A.P., LUKYANCHUK N.N., SLOBODYAN L.N.,
RA LIPKIN V.M., OVCHINNIKOV Y.A., SOROKIN V.M.;
RL FEBS LETT. 36:77-78(1973).
RN [3]
RP STRUCTURE BY NMR.
RM 93279322
RA GOLOVANOV A.P., LOMIZE A.L., ARSENIEV A.S., UTKIN Y.N., TSETLIN V.I.;
RL EUR. J. BIOCHEM. 213:1213-1223(1993).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; A01696; N1NJ1R.
DR PDB; 1NOR; 31-OCT-93.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW 3D-STRUCTURE.
FT DISULFID 3 23
FT DISULFID 17 40
FT DISULFID 42 53
FT DISULFID 54 59
SQ SEQUENCE 61 AA; 6885 MW; 17042 CN;
LECHNQQSSQ PPTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVN LNCCRTDRCN 60
N 61
//
ID NXS1_NAJPA STANDARD; PRT; 61 AA.
AC P01426;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN ALPHA).
OS NAJA PALLIDA (RED SPITTING COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA EAKER D.L., PORATH J.;
RL JPN. J. MICROBIOL. 11:353-355(1967).
RN [2]
RP STRUCTURE BY NMR.
RM 93075732
RA ZINN-JUSTIN S., ROUMESTAND C., GILQUIN B., BONTEMS F., MENEZ A.,
RA TOMA F.;
RL BIOCHEMISTRY 31:11335-11347(1992).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.036 MG/KG BY SUBCUTANEOUS INJECTION.
CC -!- CAUTION: THE VENOM OF THIS SNAKE WAS ORIGINALLY THOUGHT TO BE THAT
CC OF N.NIGRICOLLIS.
DR PIR; A01695; N1NJ1B.
DR PDB; 1NEA; 31-OCT-93.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY;
KW 3D-STRUCTURE.
FT DISULFID 3 23
FT DISULFID 17 40
FT DISULFID 42 53
FT DISULFID 54 59
SQ SEQUENCE 61 AA; 6795 MW; 18257 CN;
LECHNQQSSQ PPTTKTCPGE TNCYKKVWRD HRGTIIERGC GCPTVKPGIK LNCCTTDKCN 60
N 61
//
ID NXS1_NAJPH STANDARD; PRT; 61 AA.
AC P01428;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1.
OS NAJA PHILIPPINENSIS (PHILIPPINE COBRA), AND NAJA SAMARENSIS (VISAYAN
OS COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP MAJOR COMPONENT, SEQUENCE.
RC SPECIES=N.PHILIPPINENSIS; TISSUE=VENOM;
RM 75040608
RA HAUERT J., MAIRE M., SUSSMANN A., BARGETZI J.P.;
RL INT. J. PEPT. PROTEIN RES. 6:201-222(1974).
RN [2]
RP MINOR COMPONENT, SEQUENCE.
RC SPECIES=N.PHILIPPINENSIS, AND N.SAMARENSIS; TISSUE=VENOM;
RA HAUERT J.;
RL THESIS (1977), UNIVERSITY OF GENEVA, SWITZERLAND.
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.05 MG/KG BY INTRAVENOUS INJECTION.
CC -!- THE SEQUENCE OF SHORT NEUROTOXIN 1 FROM N.N.SAMARENSIS IS
CC IDENTICAL WITH THE MAJOR COMPONENT FROM N.N.PHILIPPINENSIS.
DR PIR; A91768; N1NJ1P.
DR PIR; B94448; N1NJ2P.
DR PIR; A01696; N1NJ1S.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT VARIANT 55 55 R -> T (IN MINOR COMPONENT).
SQ SEQUENCE 61 AA; 6873 MW; 17338 CN;
LECHNQQSSQ APTTKTCSGE TNCYKKWWSD HRGTIIERGC GCPKVKPGVK LNCCRTDRCN 60
N 61
//
ID NXS1_PSEAU STANDARD; PRT; 62 AA.
AC P25497;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 1 (NEUROTOXIN PA A).
OS PSEUDECHIS AUSTRALIS (MULGA SNAKE) (KING BROWN SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 86130341
RA TAKASAKI C., TAMIYA N.;
RL BIOCHEM. J. 232:367-371(1985).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.076 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6758 MW; 18858 CN;
MTCCNQQSSQ PKTTTICAGG ESSCYKKTWS DHRGSRTERG CGCPHVKPGI KLTCCKTDEC 60
NN 62
//
ID NXS2_AIPLA STANDARD; PRT; 81 AA.
AC P19959; P01439;
DT 01-FEB-1991 (REL. 17, CREATED)
DT 01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN B PRECURSOR.
OS AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90232535
RA DUCANCEL F., GUIGNERY-FRELAT G., BOULAIN J.-C., MENEZ A.;
RL TOXICON 28:119-123(1990).
RN [2]
RP SEQUENCE OF 22-81.
RC TISSUE=VENOM;
RM 76160626
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 153:79-87(1976).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR EMBL; X13373; ALTOXB.
DR PIR; A01707; N1AY1.
DR PIR; S03391; S03391.
DR PIR; A34019; A34019.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 81 SHORT NEUROTOXIN B.
FT DISULFID 24 43 BY SIMILARITY.
FT DISULFID 38 60 BY SIMILARITY.
FT DISULFID 62 73 BY SIMILARITY.
FT DISULFID 74 79 BY SIMILARITY.
SQ SEQUENCE 81 AA; 9047 MW; 30666 CN;
MKTLLLTLVV VTIVCLDLGY TLTCCNQQSS QPKTTTDCAD NSCYKMTWRD HRGTRIERGC 60
GCPQVKPGIK LECCKTNECN N 81
//
ID NXS2_BUNFA STANDARD; PRT; 63 AA.
AC P14534;
DT 01-JAN-1990 (REL. 13, CREATED)
DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (TOXIN V-II-2) (FASCIATOXIN).
OS BUNGARUS FASCIATUS (BANDED KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 89246298
RA LIU C.-S., HSIAO P.-W., CHANG C.-S., TZENG M.-C., LO T.-B.;
RL BIOCHEM. J. 259:153-158(1989).
CC -!- FUNCTION: BLOCKS BOTH THE MUSCLE-TWITCH RESPONSE TO NERVE
CC STIMULATION AND THE RESPONSE TO EXOGENOUS ACETYLCHOLINE.
CC -!- IN CONTRAST TO OTHER SNAKE TOXINS THE ACTION OF THIS TOXIN IS
CC REVERSIBLE.
CC -!- UNUSUAL A.A. SEQUENCE DISTINCTLY DIFFERENT FROM OTHER SHORT-CHAIN
CC TYPE TOXINS.
DR PIR; S03864; S03864.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 15 39 BY SIMILARITY.
FT DISULFID 43 49 BY SIMILARITY.
FT DISULFID 50 55 BY SIMILARITY.
SQ SEQUENCE 63 AA; 6847 MW; 21415 CN;
LKCHKAQFPN IETQCKWQTL CFQRDVKPHP SSMIVLRGCT SSCGKGAMCC ATDLCNGPST 60
PST 63
//
ID NXS2_ENHSC STANDARD; PRT; 60 AA.
AC P25493; P01436;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (TOXIN 5) (PELAMITOXIN A) (HYDROPHITOXIN B).
OS ENHYDRINA SCHISTOSA (BEAKED SEA SNAKE) (COMMON SEA SNAKE),
OS PELAMIS PLATURUS (YELLOW-BELLIED SEA SNAKE) (PELAGIC SEA SNAKE),
OS AND HYDROPHIS CYANOCINCTUS (ASIAN ANNULATED SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP TOXIN 5, SEQUENCE.
RC SPECIES=E.SCHISTOSA; TISSUE=VENOM;
RM 73127342
RA FRYKLUND L., EAKER D., KARLSSON E.;
RL BIOCHEMISTRY 11:4633-4640(1972).
RN [2]
RP PELAMITOXIN A, SEQUENCE.
RC SPECIES=P.PLATURUS; TISSUE=VENOM;
RM 77105547
RA WANG C.L., LIU C.-S., HUNG Y.O., BLACKWELL R.Q.;
RL TOXICON 14:459-466(1976).
RN [3]
RP HYDROPHITOXIN B, SEQUENCE.
RC SPECIES=H.CYNOCINCTUS; TISSUE=VENOM;
RM 75160244
RA LUI C.-S., BLACKWELL R.Q.;
RL TOXICON 12:543-546(1974).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.07 MG/KG BY INTRAPERITONAL INJECTION FOR PELAMITOXIN
CC A AND 0.085 MG/KG BY INTRAVENOUS INJECTION FOR HYDROPHITOXIN B.
DR PIR; B01705; N1EY15.
DR PIR; A94310; N1EY1P.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6687 MW; 16569 CN;
MTCCNQQSSQ PKTTTNCAES SCYKKTWSDH RGTRIERGCG CPQVKSGIKL ECCHTNECNN 60
//
ID NXS2_HEMHA STANDARD; PRT; 61 AA.
AC P01433;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (TOXIN IV).
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 71116407
RA STRYDOM A.J.C., BOTES D.P.;
RL J. BIOL. CHEM. 246:1341-1349(1971).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.09 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01701; N1RI2.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6832 MW; 18592 CN;
LECHNQQSSQ TPTTQTCPGE TNCYKKQWSD HRGSRTERGC GCPTVKPGIK LKCCTTDRCN 60
K 61
//
ID NXS2_LATCO STANDARD; PRT; 62 AA.
AC P10457;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN II.
OS LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC STRAIN=JAPANESE AND PHILLIPINE; TISSUE=VENOM;
RA TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL TOXICON SUPPL. 3:445-447(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; B25866; B25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7037 MW; 17544 CN;
RRCYNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPTVKPGI KLRCCESEDC 60
NN 62
//
ID NXS2_NAJHA STANDARD; PRT; 61 AA.
AC P01422;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (TOXIN CM-14) (TOXIN V-N-I2).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.12 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01691; N1NJ2E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6915 MW; 18174 CN;
MICHNQQSSQ PPTIKTCPGE TNCYKKRWRD HRGTIIERGC GCPSVKKGVG IYCCKTNKCN 60
R 61
//
ID NXS2_NAJHH STANDARD; PRT; 61 AA.
AC P25675;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (TOXIN CM-10A).
OS NAJA HAJE HAJE (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79062487
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 537:1-8(1978).
CC -!- LD(50) IS 0.08 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6888 MW; 18339 CN;
MICHNQQSSQ PPTIKTCPGE TNCYKKQWRD HRGTIIERGC GCPSVKKGVG IYCCKTDKCN 60
R 61
//
ID NXS2_NAJNI STANDARD; PRT; 61 AA.
AC P01423;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 2 (NEUROTOXIN BETA).
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 72068724
RA BOTES D.P.;
RL J. BIOL. CHEM. 246:7383-7391(1971).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.08 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01692; N1NJ1C.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6975 MW; 18088 CN;
MICHNQQSSQ RPTIKTCPGE TNCYKKRWRD HRGTIIERGC GCPSVKKGVG IYCCKTDKCN 60
R 61
//
ID NXS3_AIPLA STANDARD; PRT; 60 AA.
AC P19958; P01439;
DT 01-FEB-1991 (REL. 17, CREATED)
DT 01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN C.
OS AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76160626
RA MAEDA N., TAMIYA N.;
RL BIOCHEM. J. 153:79-87(1976).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.067 MG/KG BY INTRAMUSCULAR INJECTION.
DR PIR; A01707; N1AY1.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6726 MW; 16270 CN;
LTCCNQQSSQ PKTTTDCADN SCYKKTWKDH RGTRIERGCG CPQVKPGIKL ECCKTNECNN 60
//
ID NXS3_NAJHA STANDARD; PRT; 61 AA.
AC P01420;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 3 (TOXIN CM-10) (TOXIN V-NH-I1).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 5.0 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01689; N1NJ3E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6885 MW; 17822 CN;
MICYKQQSLQ FPITTVCPGE KNCYKKQWSG HRGTIIERGC GCPSVKKGIE INCCTTDKCN 60
R 61
//
ID NXS3_NAJMO STANDARD; PRT; 62 AA.
AC P01432;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 3 (NEUROTOXIN III).
OS NAJA MOSSAMBICA (MOZAMBIQUE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 78043196
RA GREGOIRE J., ROCHAT H.;
RL EUR. J. BIOCHEM. 80:283-293(1977).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 0.05 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01700; N1NJ3M.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7218 MW; 17843 CN;
LNCHNQMSAQ PPTTTRCSRW ETNCYKKRWR DHRGYKTERG CGCPTVKKGI QLHCCTSDNC 60
NN 62
//
ID NXS4_AIPLA STANDARD; PRT; 81 AA.
AC P19960;
DT 01-FEB-1991 (REL. 17, CREATED)
DT 01-FEB-1991 (REL. 17, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN D PRECURSOR.
OS AIPYSURUS LAEVIS (OLIVE SEA SNAKE).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90232535
RA DUCANCEL F., GUIGNERY-FRELAT G., BOULAIN J.-C., MENEZ A.;
RL TOXICON 28:119-123(1990).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR EMBL; X13372; ALTOXD.
DR PIR; S03390; S03390.
DR PIR; B34019; B34019.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 81 SHORT NEUROTOXIN D.
FT DISULFID 24 43 BY SIMILARITY.
FT DISULFID 38 60 BY SIMILARITY.
FT DISULFID 62 73 BY SIMILARITY.
FT DISULFID 74 79 BY SIMILARITY.
SQ SEQUENCE 81 AA; 9017 MW; 31151 CN;
MKTLLLTLVV VTIVCLDLGY TLTCCNQQSS QPKTTTDCAD DSCYKKTWKD HRGTRIERGC 60
GCPQVKPGIK LECCKTNECN N 81
//
ID NXS4_NAJHA STANDARD; PRT; 61 AA.
AC P01421;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN 4 (TOXIN CM-12) (TOXIN V-NH-I2).
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:53-72(1975).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
CC -!- LD(50) IS 62.5 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01690; N1NJ4E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6913 MW; 17794 CN;
MICYKQRSLQ FPITTVCPGE KNCYKKQWSG HRGTIIERGC GCPSVKKGIE INCCTTDKCN 60
R 61
//
ID NXSA_LATCR STANDARD; PRT; 62 AA.
AC P25495;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN A.
OS LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL TOXICON SUPPL. 3:445-447(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7023 MW; 16883 CN;
RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTIIERG CGCPTVKPGI KLRCCQSDDC 60
NN 62
//
ID NXSB_LATCR STANDARD; PRT; 62 AA.
AC P25496;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN B.
OS LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL TOXICON SUPPL. 3:445-447(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7040 MW; 16436 CN;
RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTIIERG CGCPQVKSGI KLRCCQSDDC 60
NN 62
//
ID NXSB_LATLA STANDARD; PRT; 62 AA.
AC P10459;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN B.
OS LATICAUDA LATICAUDATA (BLUE-RINGED SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 86159724
RA TAMIYA N.,
RL UNPUBLISHED RESULTS, CITED BY:
RL ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL HAYASHI K.;
RL BIOCHEMISTRY 25:395-404(1986).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; G25866; G25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6973 MW; 17490 CN;
RRCFNHPSSQ PQTNKSCPPG ENSCYNKQWR DHRGTITERG CGCPQVKSGI KLTCCQSDDC 60
NN 62
//
ID NXSC_LATCO STANDARD; PRT; 62 AA.
AC P10455;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN C.
OS LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC STRAIN=SALOMON ISLAND AND FIJI; TISSUE=VENOM;
RA TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL TOXICON SUPPL. 3:445-447(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; C25866; C25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7064 MW; 17319 CN;
RRCYNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPKVKPGI KLRCCESEDC 60
NN 62
//
ID NXSC_LATCR STANDARD; PRT; 62 AA.
AC P10458;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN C.
OS LATICAUDA CROCKERI (CROCKER'S SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 86159724
RA TAMIYA N.,
RL UNPUBLISHED RESULTS, CITED BY:
RL ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL HAYASHI K.;
RL BIOCHEMISTRY 25:395-404(1986).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; F25866; F25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7101 MW; 16950 CN;
RRCFNQQSSQ PQTNKSCPPG ENSCYRKQWR DHRGTIIERG CGCPTVKPGI KLRCCQSEDC 60
NN 62
//
ID NXSC_LATLA STANDARD; PRT; 62 AA.
AC P10460;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN C.
OS LATICAUDA LATICAUDATA (BLUE-RINGED SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 86159724
RA TAMIYA N.,
RL UNPUBLISHED RESULTS, CITED BY:
RL ENDO T., NAKANISHI M., FURUKAWA S., JOUBERT F.J., TAMIYA N.,
RL HAYASHI K.;
RL BIOCHEMISTRY 25:395-404(1986).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; E25866; E25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7087 MW; 17450 CN;
RRCFNQQSSQ PQTNKSCPPG ENSCYRKQWR DHRGTIIERG CGCPTVKPGV KLRCCQSEDC 60
NN 62
//
ID NXSD_LATCO STANDARD; PRT; 62 AA.
AC P10456;
DT 01-MAR-1989 (REL. 10, CREATED)
DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SHORT NEUROTOXIN D.
OS LATICAUDA COLUBRINA (YELLOW-LIPPED SEA KRAIT).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC STRAIN=NEW CALEDONIA; TISSUE=VENOM;
RA TAMIYA N., SATO A., KIM H.S., TERUUCHI T., TAKASAKI C., ISHIKAWA Y.,
RA GUINEA M.L., MCCOY M., HEATWOLE H., COGGER H.G.;
RL TOXICON SUPPL. 3:445-447(1983).
CC -!- FUNCTION: PRODUCES PERIPHERAL PARALYSIS BY BLOCKING NEUROMUSCULAR
CC TRANSMISSION AT THE POSTSYNAPTIC SITE. BINDS TO THE NICOTINIC
CC ACETYLCHOLINE RECEPTOR.
DR PIR; D25866; D25866.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; POSTSYNAPTIC NEUROTOXIN; MULTIGENE FAMILY.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 43 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 7048 MW; 17299 CN;
RRCFNQQSSQ PKTTKSCPPG ENSCYNKQWR DHRGSITERG CGCPKVKPGI KLRCCESEDC 60
NN 62
//
ID TS24_DENJA STANDARD; PRT; 62 AA.
AC P01407;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-TYPE VENOM PROTEIN S2C4.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79171275
RA JOUBERT F.J., TALJAARD N.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:571-580(1979).
CC -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO IDENTICAL CHAINS
CC LINKED BY AT LEAST TWO INTERCHAIN DISULFIDE BONDS.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
DR PIR; A01678; V6EP2J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 62 AA; 6726 MW; 18029 CN;
LTCVTDKSFG GVNTEECAAG QKICFKNWKK MGPKLYDVKR GCTATCPKAD DDGCVKCCNT 60
DK 62
//
ID TS81_DENAN STANDARD; PRT; 62 AA.
AC P01410;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-TYPE VENOM PROTEIN C8S2, CHAIN 1.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80070629
RA JOUBERT F.J., VILJOEN C.C.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC CHAINS, C8S2 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC DISULFIDE BONDS.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
DR PIR; A01680; V6EP8A.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 62 AA; 6684 MW; 18939 CN;
LTCVTGKSIG GISTEECAAG QKRCFKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCNI 60
DK 62
//
ID TS82_DENAN STANDARD; PRT; 62 AA.
AC P01411;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-TYPE VENOM PROTEIN C8S2, CHAIN 2.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80070629
RA JOUBERT F.J., VILJOEN C.C.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC CHAINS, C8S2 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC DISULFIDE BONDS.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
DR PIR; A01681; V6EP82.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 62 AA; 6582 MW; 18636 CN;
LTCVTGKSIG GISTEECAAG QKRCNKKWTK MGPKLYDVSR GCAATCPTAD EYGCVKCCNT 60
DK 62
//
ID TS91_DENAN STANDARD; PRT; 63 AA.
AC P01408;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-TYPE VENOM PROTEIN C9S3, CHAIN 1.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80070629
RA JOUBERT F.J., VILJOEN C.C.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC CHAINS, C9S3 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC DISULFIDE BONDS.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
DR PIR; A01679; V6EP9A.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 63 AA; 6785 MW; 19643 CN;
LTCVTGKSIG GISTEECAAG QKICFKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCKT 60
DRN 63
//
ID TS92_DENAN STANDARD; PRT; 63 AA.
AC P01409;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-TYPE VENOM PROTEIN C9S3, CHAIN 2.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80070629
RA JOUBERT F.J., VILJOEN C.C.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 360:1075-1090(1979).
CC -!- FUNCTION: THIS PROTEIN SHOWS A SYNERGETIC TOXIC EFFECT IN THAT
CC IT ENHANCES THE TOXICITY OF AN ANGUSTICEPS TYPE TOXIN.
CC -!- SUBUNIT: THE FUNCTIONAL MOLECULE CONSISTS OF TWO NONIDENTICAL
CC CHAINS, C9S3 CHAIN 1 AND CHAIN 2, LINKED BY AT LEAST 2 INTERCHAIN
CC DISULFIDE BONDS.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
DR PIR; B01679; V6EP92.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 63 AA; 6738 MW; 18837 CN;
LTCVTGKSIG GISTEECAAG QKICNKKWTK MGPKLYDVSR GCTATCPKAD EYGCVKCCNT 60
DRN 63
//
ID TSYL_DENAN STANDARD; PRT; 86 AA.
AC P17696;
DT 01-AUG-1990 (REL. 15, CREATED)
DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-LIKE VENOM PROTEIN PRECURSOR.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 90221903
RA ROWAN E., DUCANCEL F., DOLJANSKY Y., HARVEY A., MENEZ A.,
RA BOULAIN J.-C.;
RL NUCLEIC ACIDS RES. 18:1639-1639(1990).
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
CC -!- SIMILARITY: TO SYNERGISTIC-TYPE SNAKE VENOM PROTEINS.
DR EMBL; X51467; DASLTOX.
DR PIR; S09235; S09235.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 86 SYNERGISTIC-LIKE PROTEIN.
SQ SEQUENCE 86 AA; 9307 MW; 37744 CN;
MKTLLLTLVV VTIVCLDLGY TLTCVTGKSI GGISTEECAA GQKICFKKWT KMGPKLYDVS 60
RGCTATCPKA DEYGCVKCCK TDRCNK 86
//
ID TSYL_DENPO STANDARD; PRT; 65 AA.
AC P25518;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE SYNERGISTIC-LIKE VENOM PROTEIN CM-3.
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 85285976
RA JOUBERT F.J.;
RL INT. J. BIOCHEM. 17:695-699(1985).
CC -!- FUNCTION: NOT KNOWN. DOES NOT SHOW A SYNERGETIC TOXIC EFFECT.
CC -!- PTM: THE CYSTEINE RESIDUES ARE INVOLVED IN INTRACHAIN DISULFIDE
CC BONDS.
CC -!- LD(50) IS 56 MG/KG BY INTRAVENOUS INJECTION.
CC -!- SIMILARITY: TO SYNERGISTIC-TYPE SNAKE VENOM PROTEINS.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
SQ SEQUENCE 65 AA; 7344 MW; 20980 CN;
LTCVTSKSIF GITTEDCPDG QNLCFKRRHY VVPKIYDITR GCVATCPIPE NYDSIHCCKT 60
EKCNN 65
//
ID TX02_DENAN STANDARD; PRT; 60 AA.
AC P25684;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN C10S2C2.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80242820
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 623:449-456(1980).
CC -!- LD(50) IS 23 +-3 MG/KG BY INTRAVENOUS INJECTION.
CC -!- SIMILARITY: STRONG, TO CALCISEPTINE.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6818 MW; 17412 CN;
RICYSHKASL PRATKTCVEN SCYKMFIRTS PDYISDRGCG CPTAMWPYQT ACCKGDRCNK 60
//
ID TX12_TRIWA STANDARD; PRT; 22 AA.
AC P24335;
DT 01-MAR-1992 (REL. 21, CREATED)
DT 01-MAR-1992 (REL. 21, LAST SEQUENCE UPDATE)
DT 01-AUG-1992 (REL. 23, LAST ANNOTATION UPDATE)
DE TOXINS 1 AND 2.
OS TRIMERESURUS WAGLERI (WAGLER'S PIT VIPER).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91263101
RA WEINSTEIN S.A., SCHMIDT J.J., BERNHEIMER A.W., SMITH L.A.;
RL TOXICON 29:227-236(1991).
CC -!- FUNCTION: ELICIT TACHYPNEA, OCULAR PROCTOSIS, RAPID COLLAPSE
CC AND SPASMS IN MICE.
CC -!- THE SEQUENCE SHOWN IS THAT OF TOXIN 1.
DR PIR; A39559; A39559.
DR PIR; B39559; B39559.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 9 13 PROBABLE.
FT VARIANT 10 10 H -> Y (IN TOXIN 2).
SQ SEQUENCE 22 AA; 2522 MW; 2631 CN;
GGKPDLRPCH PPCHYIPRPK PR 22
//
ID TX31_DENAN STANDARD; PRT; 80 AA.
AC P18329;
DT 01-NOV-1990 (REL. 16, CREATED)
DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN C13S1C1 PRECURSOR.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RA DUCANCEL F.;
RL SUBMITTED (MAR-1990) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [2]
RP SEQUENCE OF 22-80.
RC TISSUE=VENOM;
RM 80242820
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 623:449-456(1980).
CC -!- LD(50) IS 40 +- 3 MG/KG BY INTRAVENOUS INJECTION.
DR EMBL; X52260; DAFLP.
DR EMBL; X53410; DADACSCI.
DR PIR; S10464; S10464.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW TOXIN; VENOM; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 80 TOXIN C13S1C1.
FT DISULFID 24 43 BY SIMILARITY.
FT DISULFID 38 60 BY SIMILARITY.
FT DISULFID 62 73 BY SIMILARITY.
FT DISULFID 74 79 BY SIMILARITY.
FT CONFLICT 56 56 MISSING (IN REF. 2).
SQ SEQUENCE 80 AA; 8954 MW; 32543 CN;
MKTLLLTLLV VTIVCLDLAH TRICYSHKLL QAKTTKTCEE NSCYKRSLPK IPLIIIGRGC 60
GCPLTLPFLR IKCCTSDKCN 80
//
ID TX48_DENJA STANDARD; PRT; 60 AA.
AC P25683;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN S4C8.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 81044628
RA JOUBERT F.J., TALJAARD N.;
RL INT. J. BIOCHEM. 12:567-574(1980).
CC -!- LD(50) IS 13.7 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6968 MW; 17513 CN;
RICYTHKSLQ AKTTKSCEGN TCYKMFIRTS REYISERGCG CPTAMWPYQT ECCKGDRCNK 60
//
ID TX49_DENVI STANDARD; PRT; 60 AA.
AC P01405;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN 4.9.6.
OS DENDROASPIS VIRIDIS (WESTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 75075137
RA SHIPOLINI R.A., BANKS B.E.C.;
RL EUR. J. BIOCHEM. 49:399-405(1974).
CC -!- LD(50) IS >3.3 MG/KG BY INTRAPERITONEAL INJECTION.
DR PIR; A01676; T5EP2V.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 38 BY SIMILARITY.
FT DISULFID 40 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6800 MW; 17236 CN;
MICYSHKTPQ NSATITCEEK TCYKFVTKLP GVILARGCGC PKKEIFRKSI HCCRSDKCNE 60
//
ID TX50_DENJA STANDARD; PRT; 58 AA.
AC P01419;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN S5C10.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RM 79232598
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 579:228-233(1979).
CC -!- LD(50) IS 5.5 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01688; N1EP2J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 50 BY SIMILARITY.
FT DISULFID 51 56 BY SIMILARITY.
SQ SEQUENCE 58 AA; 6521 MW; 16040 CN;
RICYNHQSNT PATTKSCVEN SCYKSIWADH RGTIIKRGCG CPRVKSKIKC CKSDNCNL 58
//
ID TX51_DENJA STANDARD; PRT; 61 AA.
AC P01413;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE TOXIN S5C1.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79232598
RA JOUBERT F.J., TALJAARD N.;
RL BIOCHIM. BIOPHYS. ACTA 579:228-233(1979).
CC -!- FUNCTION: INHIBITS ADP-INDUCED PLATELET AGGREGATION AND INHIBITS
CC THE BINDING OF PURIFIED PLATELET FIBRINOGEN RECEPTOR GPIIB-IIIA
CC TO IMMOBILIZED FIBRINOGEN (BY SIMILARITY TO MAMBIN).
CC -!- SIMILARITY: STRONG, TO MAMBIN.
DR PIR; A01683; T6EP5J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW BLOOD COAGULATION; CELL ADHESION; VENOM.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 16 39 BY SIMILARITY.
FT DISULFID 41 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
FT SITE 45 47 CELL ATTACHMENT SITE (POTENTIAL).
SQ SEQUENCE 61 AA; 7024 MW; 17382 CN;
RICYNHLGTK PPTTECTQED SCYKNIWRNI TFDNIRRGCG CFTPRGDMPG PYCCESDKCN 60
L 61
//
ID TX54_DENJA STANDARD; PRT; 60 AA.
AC P01406;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN S5C4.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 78216714
RA JOUBERT F.J., STRYDOM A.J.C., TALJAARD N.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 359:741-749(1978).
CC -!- LD(50) IS >250 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01677; T5EP2J.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6772 MW; 17208 CN;
MICYSHKTPQ NSATITCEEK TCYKKFVTNV PGVILARGCG CPKKEIFRSI HCCRSDKCNE 60
//
ID TX64_DENJA STANDARD; PRT; 63 AA.
AC P25682;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN S6C4.
OS DENDROASPIS JAMESONI KAIMOSAE (EASTERN JAMESON'S MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J., TALJAARD N.;
RL S. AFR. J. CHEM. 32:151-155(1979).
CC -!- LD(50) IS 10 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 43 55 BY SIMILARITY.
FT DISULFID 56 61 BY SIMILARITY.
SQ SEQUENCE 63 AA; 7397 MW; 20521 CN;
LECYRCGVSG CHLRTTCSAK EKFCAKQHNR ISTLWWHGCV ETCTEDETWK FYRKCCTTNL 60
CNI 63
//
ID TXAC_DENPO STANDARD; PRT; 61 AA.
AC P25681;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE ACETYLCHOLINESTERASE TOXIN C.
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J., TALJAARD N.;
RL S. AFR. J. CHEM. 31:107-110(1978).
CC -!- FUNCTION: INHIBITS ACETYLCHOLINESTERASE.
CC -!- LD(50) IS 2.1 +- 0.2 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6817 MW; 19099 CN;
TICYSHTTTS RAILKDCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDYLEV KCCTSPDKCN 60
Y 61
//
ID TXCA_DENPO STANDARD; PRT; 60 AA.
AC P22947;
DT 01-AUG-1991 (REL. 19, CREATED)
DT 01-AUG-1991 (REL. 19, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE CALCISEPTINE (L-TYPE CALCIUM CHANNEL BLOCKER).
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91172823
RA DE WEILLE J.R., SCHWEITZ H., MAES P., TARTAR A., LAZDUNSKI M.;
RL PROC. NATL. ACAD. SCI. U.S.A. 88:2437-2440(1991).
CC -!- FUNCTION: THIS SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL IS A
CC SMOOTH MUSCLE RELAXANT AND AN INHIBITOR OF CARDIAC CONTRACTIONS.
CC -!- THE SENSITIVITY IS HIGHER IN CELLS OF THE CARDIOVASCULAR SYSTEM.
CC NEURONAL, AND INSULINOMA CELLS L-TYPE CALCIUM CHANNEL ARE MORE
CC RESISTANTS. A TOTAL RESISTANCE IS FOUND IN SKELETAL MUSCLE CELLS.
CC -!- SIMILARITY: STRONG, TO THE TOXIN FS-2 AND TO C10S2C2.
DR PIR; A39165; A39165.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; CYTOTOXIN; CARDIOTOXIN; CALCIUM CHANNEL INHIBITOR.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 7044 MW; 17210 CN;
RICYIHKASL PRATKTCVEN TCYKMFIRTQ REYISERGCG CPTAMWPYQT ECCKGDRCNK 60
//
ID TXF2_DENPO STANDARD; PRT; 60 AA.
AC P01414;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE TOXIN FS-2.
OS DENDROASPIS POLYLEPIS POLYLEPIS (BLACK MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77225275
RA STRYDOM D.J.;
RL EUR. J. BIOCHEM. 76:99-106(1977).
CC -!- LD(50) IS 8 MG/KG BY SUBCUTANEOUS INJECTION.
CC -!- SIMILARITY: STRONG, TO CALCISEPTINE.
DR PIR; A01684; T6EP3D.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 22 BY SIMILARITY.
FT DISULFID 17 39 BY SIMILARITY.
FT DISULFID 41 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 7026 MW; 17298 CN;
RICYSHKASL PRATKTCVEN TCYKMFIRTH RQYISERGCG CPTAMWPYQT ECCKGDRCNK 60
//
ID TXF7_DENAN STANDARD; PRT; 61 AA.
AC P01403;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE FASCICULIN I (ACETYLCHOLINESTERASE TOXIN F-VII) (TOXIN TA1).
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 73215577
RA VILJOEN C.C., BOTES D.P.;
RL J. BIOL. CHEM. 248:4915-4919(1973).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RM 93054489
RA LE DU M.H., MARCHOT P., BOUGIS P.E., FONTECILLA-CAMPS J.C.;
RL J. BIOL. CHEM. 267:22122-22130(1992).
CC -!- FUNCTION: INHIBITS ACETYLCHOLINESTERASE. THE WHOLE VENOM HAS
CC ANTICOAGULANT ACTIVITY, AND THE VARIOUS COMPONENTS SEEM TO ACT
CC SYNERGISTICALLY.
CC -!- LD(50) IS >20 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01674; T4EP1A.
DR PDB; 1FAS; 31-OCT-93.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN; 3D-STRUCTURE.
FT DISULFID 3 22
FT DISULFID 17 39
FT DISULFID 41 52
FT DISULFID 53 59
FT VARIANT 47 47 N -> Y.
SQ SEQUENCE 61 AA; 6758 MW; 18412 CN;
TMCYSHTTTS RAILTNCGEN SCYRKSRRHP PKMVLGRGCG CPPGDDNLEV KCCTSPDKCN 60
Y 61
//
ID TXF8_DENAN STANDARD; PRT; 81 AA.
AC P01404;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE)
DT 01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE TOXIN F-VIII PRECURSOR (TOXIN TA2) (TOXIN DAF8).
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RA DUCANCEL F.;
RL SUBMITTED (JUN-1990) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN [2]
RP SEQUENCE OF 22-81.
RC TISSUE=VENOM;
RM 74070661
RA VILJOEN C.C., BOTES D.P.;
RL J. BIOL. CHEM. 249:366-372(1974).
CC -!- FUNCTION: ITS PHARMACOLOGICAL ACTION IS UNKNOWN. IT PROBABLY ACTS
CC SYNERGISTICALLY WITH OTHER VENOM COMPONENTS AS WHOLE VENOM IS VERY
CC TOXIC.
CC -!- LD(50) IS >250 MG/KG BY SUBCUTANEOUS INJECTION.
DR EMBL; X53409; DADAF8.
DR PIR; A01675; T5EP2A.
DR PIR; S21299; S21299.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 81 TOXIN F-VIII.
FT DISULFID 24 43 BY SIMILARITY.
FT DISULFID 38 60 BY SIMILARITY.
FT DISULFID 62 73 BY SIMILARITY.
FT DISULFID 74 79 BY SIMILARITY.
FT CONFLICT 54 54 I -> V (IN REF. 2).
SQ SEQUENCE 81 AA; 8849 MW; 32586 CN;
MKTLLLTLLV VTIVCLDLAS TMICYSHKTP QPSATITCEE KTCYKKSVRK LPAIVAGRGC 60
GCPSKEMLVA IHCCRSDKCN E 81
//
ID TXM2_DENAN STANDARD; PRT; 86 AA.
AC P18328;
DT 01-NOV-1990 (REL. 16, CREATED)
DT 01-NOV-1990 (REL. 16, LAST SEQUENCE UPDATE)
DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE MUSCARINIC TOXIN 2 PRECURSOR.
OS DENDROASPIS ANGUSTICEPS (EASTERN GREEN MAMBA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE FROM N.A.
RC TISSUE=VENOM GLAND;
RM 91320365
RA DUCANCEL F., ROWAN E.G., CASSAR E., HARVEY A.L., MENEZ A.,
RA BOULAIN J.-C.;
RL TOXICON 29:516-520(1991).
RN [2]
RP SEQUENCE OF 22-86.
RC TISSUE=VENOM;
RM 91320366
RA KARLSSON E., RISINGER C., JOLKKONEN M., WERNSTEDT C., ADEM A.;
RL TOXICON 29:521-526(1991).
CC -!- FUNCTION: BINDS TO THE MUSCARINIC ACETYLCHOLINE RECEPTOR.
DR EMBL; X52292; DATM1.
DR PIR; A37910; A37910.
DR PIR; A37911; A37911.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; NEUROTOXIN; SIGNAL.
FT SIGNAL 1 21
FT CHAIN 22 86 MUSCARINIC TOXIN 2.
FT DISULFID 24 45 BY SIMILARITY.
FT DISULFID 38 63 BY SIMILARITY.
FT DISULFID 67 78 BY SIMILARITY.
FT DISULFID 79 84 BY SIMILARITY.
SQ SEQUENCE 86 AA; 9375 MW; 35965 CN;
MKTLLLTLVV VTIVCLDLGY TLTCVTTKSI GGVTTEDCPA GQNVCFKRWH YVTPKNYDII 60
KGCAATCPKV DNNDPIRCCG TDKCND 86
//
ID TXW0_NAJNI STANDARD; PRT; 65 AA.
AC P25680;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-10.
OS NAJA NIVEA (CAPE COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80202933
RA JOUBERT F.J., TALJAARD N.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:425-436(1980).
CC -!- LD(50) IS 16 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7545 MW; 19216 CN;
LRCLNCPEVF CRNFHTCRNG EKICFKRFDQ RKLLGKRYTR GCAVTCPVAK PREIVECCST 60
DGCNR 65
//
ID TXW1_NAJHH STANDARD; PRT; 65 AA.
AC P01401;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-11.
OS NAJA HAJE HAJE (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79045337
RA JOUBERT F.J., TALJAARD N.;
RL EUR. J. BIOCHEM. 90:359-367(1978).
CC -!- LD(50) IS 13.4 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01672; V6NJ1Y.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7546 MW; 18060 CN;
LTCLICPEKY CNKVHTCRNG ENQCFKRFNE RKLLGKRYTR GCAATCPEAK PREIVECCTT 60
DRCNK 65
//
ID TXW1_OPHHA STANDARD; PRT; 60 AA.
AC P01412;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN DE-1.
OS OPHIOPHAGUS HANNAH (KING COBRA) (NAJA HANNAH).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77226507
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:565-574(1977).
CC -!- LD(50) IS >250 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01682; V7OH1D.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 23 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 42 52 BY SIMILARITY.
FT DISULFID 53 58 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6812 MW; 17395 CN;
LICFNQETYR PETTTTCPDG ENCYSTFWHN DGHVKIERGC GCPRVNPPIS ICCKTDKCNN 60
//
ID TXW2_NAJHH STANDARD; PRT; 61 AA.
AC P01415;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-2.
OS NAJA HAJE HAJE (EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 79045337
RA JOUBERT F.J., TALJAARD N.;
RL EUR. J. BIOCHEM. 90:359-367(1978).
CC -!- LD(50) IS 16.1 MG/KG BY SUBCUTANEOUS INJECTION.
DR PIR; A01685; T2NJ2Y.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 37 BY SIMILARITY.
FT DISULFID 41 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 7033 MW; 16901 CN;
FTCFTTPSDT SETCPDGQNI CYEKRWNSHQ GVEIKGCVAS CPEFESRFRY LLCCRIDNCN 60
K 61
//
ID TXW3_NAJHA STANDARD; PRT; 60 AA.
AC P25677;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-3.
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77163918
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:377-390(1977).
CC -!- LD(50) IS 16.6 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 19 BY SIMILARITY.
FT DISULFID 12 36 BY SIMILARITY.
FT DISULFID 40 48 BY SIMILARITY.
FT DISULFID 49 54 BY SIMILARITY.
SQ SEQUENCE 60 AA; 6751 MW; 17345 CN;
LECYQMSKVV TCKPEEKFCY SDVFMPFRNH VYTSGCSSYC RDGTGEKCCT TDRCNGARGG 60
//
ID TXW4_NAJME STANDARD; PRT; 65 AA.
AC P01400;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK TOXIN S4C11.
OS NAJA MELANOLEUCA (FOREST COBRA) (BLACK-LIPPED COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76019092
RA CARLSSON F.H.H.;
RL BIOCHIM. BIOPHYS. ACTA 400:310-321(1975).
CC -!- LD(50) IS >20 MG/KG BY INTRAVENOUS INJECTION.
CC -!- THE GEOGRAPHICAL LOCATION FOR THIS FOREST COBRA POPULATION WAS
CC RHODESIA.
DR PIR; A01671; V6NJ4W.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7430 MW; 18802 CN;
LTCLICPEKY CNKVHTCRNG ENICFKRFYE GNLLGKRYPR GCAATCPEAK PREIVECCST 60
DKCNH 65
//
ID TXW5_NAJNA STANDARD; PRT; 62 AA.
AC P29179;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK NEUROTOXIN 5.
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91285111
RA SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL FEBS LETT. 284:70-72(1991).
DR PIR; S15871; S15871.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 40 BY SIMILARITY.
FT DISULFID 44 54 BY SIMILARITY.
FT DISULFID 55 60 BY SIMILARITY.
SQ SEQUENCE 62 AA; 6943 MW; 18560 CN;
LTCLICPEKY CNKVHTCLNG ENICFKRFNR ILGKRYDLGC AATCPTVKTG IVQCCSTDKC 60
NH 62
//
ID TXW6_NAJNA STANDARD; PRT; 65 AA.
AC P29180;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK NEUROTOXIN 6.
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91285111
RA SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL FEBS LETT. 284:70-72(1991).
DR PIR; S16019; S16019.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7568 MW; 19871 CN;
LTCLICPEKY CNKVHTCLNG EKICFKRYSE RKLLGKRYIR GCADTCPVRK PREIVQCCST 60
DKCNH 65
//
ID TXW7_NAJNA STANDARD; PRT; 65 AA.
AC P29181;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK NEUROTOXIN 7.
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91285111
RA SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL FEBS LETT. 284:70-72(1991).
DR PIR; S16020; S16020.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7637 MW; 17274 CN;
LTCLNCPEVY CRRFQICRDG EKICFKKFDQ RNLLGKRYRR GCAATCPEAK PREIVQCCST 60
DKCNR 65
//
ID TXW8_NAJNA STANDARD; PRT; 65 AA.
AC P29182;
DT 01-DEC-1992 (REL. 24, CREATED)
DT 01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK NEUROTOXIN 8.
OS NAJA NAJA (INDIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 91285111
RA SHAFQAT J., SIDDIQI A.R., ZAIDI Z.H., JOERNVALL H.;
RL FEBS LETT. 284:70-72(1991).
DR PIR; S16021; S16021.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7581 MW; 17802 CN;
LTCLNCPEVY CRRFQKCRNG EKICFKKFDQ RNLLGKRYEI GCAATCPEAK PREIVQCCST 60
DKCNR 65
//
ID TXW9_NAJKA STANDARD; PRT; 64 AA.
AC P25679;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-9A.
OS NAJA NAJA KAOUTHIA (MONOCLED COBRA) (NAJA NAJA SIAMENSIS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80202933
RA JOUBERT F.J., TALJAARD N.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:425-436(1980).
CC -!- LD(50) IS 82 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 41 BY SIMILARITY.
FT DISULFID 45 56 BY SIMILARITY.
FT DISULFID 57 62 BY SIMILARITY.
SQ SEQUENCE 64 AA; 7493 MW; 19004 CN;
LRCLNCPEMF CGKFQICRNG EKICFKKLHQ RRPLSRYIRG CADTCPVGYP KEMIECCSTD 60
KCNR 64
//
ID TXWA_NAJHA STANDARD; PRT; 61 AA.
AC P25678;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-2A.
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 77163918
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 358:377-390(1977).
CC -!- LD(50) IS 15.4 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 19 BY SIMILARITY.
FT DISULFID 12 37 BY SIMILARITY.
FT DISULFID 41 49 BY SIMILARITY.
FT DISULFID 50 55 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6837 MW; 18024 CN;
LECYQMSKVV TCKPEETFCY SDVFMPFRNH IVYTSGCSSY CRDGTGEKCC TTDRCNGARG 60
G 61
//
ID TXWB_HEMHA STANDARD; PRT; 57 AA.
AC P01402;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-1B.
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 80236878
RA JOUBERT F.J., TALJAARD N.;
RL TOXICON 18:191-198(1980).
CC -!- LD(50) IS 11.7 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01673; T2NJBE.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 19 BY SIMILARITY.
FT DISULFID 12 37 BY SIMILARITY.
FT DISULFID 40 49 BY SIMILARITY.
FT DISULFID 50 55 BY SIMILARITY.
SQ SEQUENCE 57 AA; 6630 MW; 16557 CN;
LECYQKSKVV TCQPEQKFCY SDTMTFFPNH PVYLSGCTFC RTDESGERCC TTDRCNK 57
//
ID TXWB_NAJHA STANDARD; PRT; 65 AA.
AC P01399;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-DEC-1992 (REL. 24, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-13B.
OS NAJA HAJE ANNULIFERA (BANDED EGYPTIAN COBRA).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RM 76119554
RA JOUBERT F.J.;
RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 356:1901-1908(1975).
CC -!- LD(50) IS 4.82 MG/KG BY INTRAVENOUS INJECTION.
DR PIR; A01670; V6NJ3E.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 24 BY SIMILARITY.
FT DISULFID 6 11 BY SIMILARITY.
FT DISULFID 17 42 BY SIMILARITY.
FT DISULFID 46 57 BY SIMILARITY.
FT DISULFID 58 63 BY SIMILARITY.
SQ SEQUENCE 65 AA; 7592 MW; 18555 CN;
LTCFNCPEVY CNRFHTCRNG EKICFKRFNE RKLLGKRYTR GCAATCPVAK PREIVECCST 60
DRCNH 65
//
ID TXWC_HEMHA STANDARD; PRT; 61 AA.
AC P25676;
DT 01-MAY-1992 (REL. 22, CREATED)
DT 01-MAY-1992 (REL. 22, LAST SEQUENCE UPDATE)
DT 01-MAY-1992 (REL. 22, LAST ANNOTATION UPDATE)
DE WEAK TOXIN CM-1C.
OS HEMACHATUS HAEMACHATUS (RINGHALS) (SEPEDON HAEMACHATUS).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA;
OC LEPIDOSAURIA; SERPENTES.
RN [1]
RP SEQUENCE.
RC TISSUE=VENOM;
RA JOUBERT F.J., TALJAARD N.;
RL S. AFR. J. CHEM. 32:73-77(1979).
CC -!- LD(50) IS 54 MG/KG BY INTRAVENOUS INJECTION.
DR PROSITE; PS00272; SNAKE_TOXIN.
KW VENOM; TOXIN.
FT DISULFID 3 21 BY SIMILARITY.
FT DISULFID 14 37 BY SIMILARITY.
FT DISULFID 41 53 BY SIMILARITY.
FT DISULFID 54 59 BY SIMILARITY.
SQ SEQUENCE 61 AA; 6917 MW; 17835 CN;
FTCFTTPSDT SETCPIGNNI CYEKRWSGHG MQIEKGCVAS CPSFESHYKF LLCCRIENCN 60
Q 61
//