INF 389 Statistical methods in bioinformatics (H2003)

Exercise 5 (Hidden Markov Models)

Problem 1: From Ewens and Grant, Ch. 11: 11.1.

Problem 2: Consider the two-state HMM example (GC-rich, GC-poor) from the lecture. Apply the Viterbi algorithm to find the most probable state sequence given the observed sequence (assume uniform initial state distribution).